Product image of Natriumchloride Dirinco (Sodium Chloride) supplied by GNH India

Natriumchloride Dirinco

Active Ingredient:
Sodium Chloride
Origin:
EU

Natriumchloride Dirinco (Sodium Chloride)

Sodium Chloride, the active ingredient in Natriumchloride Dirinco, is an electrolyte presented as a solution for injection for intravenous use. It is employed to restore extracellular fluid volume and correct electrolyte imbalances in patients requiring fluid replacement, such as those with hypovolemia or dehydration.
GNH India supplies Natriumchloride Dirinco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Dirinco Bv

1
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Indications & Clinical Uses

Natriumchloride Dirinco is an intravenous electrolyte solution used to manage conditions involving fluid loss and electrolyte disturbances.

  • Fluid replacement: rehydrates patients and restores circulating blood volume.
  • Electrolyte imbalance correction: normalizes sodium and chloride levels in the extracellular compartment.
  • Hypovolemia: treats low blood volume due to bleeding, burns, or severe dehydration.

How It Works

  • Sodium Chloride provides sodium (Na⁺) and chloride (Cl⁻) ions that expand the extracellular fluid compartment when administered intravenously. The ions increase osmotic pressure, drawing water into the vascular space, thereby augmenting plasma volume and correcting hyponatremia or hypochloremia. This restores electrolyte balance and supports normal cellular function.

Side Effects

Adverse reactions may occur with any intravenous therapy.

Common Side Effects

  • Phlebitis at the infusion site: inflammation or pain.
  • Hypernatremia: elevated serum sodium if administered excessively.
  • Hyperchloremia: increased chloride levels leading to metabolic acidosis.
  • Fluid overload: signs of edema or pulmonary congestion.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis with rash, wheezing, or hypotension.
  • Electrolyte disturbances causing cardiac arrhythmias.

Precautions & Warnings

Use Natriumchloride Dirinco with clinical monitoring and appropriate indications.

  • Dosage adjustment: tailor infusion rate to patient’s fluid status and electrolyte levels.
  • Cardiac monitoring: observe for arrhythmias in patients with underlying heart disease.
  • Renal function: assess kidney function before and during therapy.
  • Compatibility: verify compatibility with other IV solutions before mixing.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Intravenous sodium chloride can affect the pharmacodynamics of several agents.

Major Interactions (Avoid)

  • Hypertonic solutions: concurrent infusion may cause severe hypernatremia.
  • Certain antibiotics (e.g., aminoglycosides): high sodium load can increase nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may require adjustment of sodium chloride infusion rate.
  • ACE inhibitors or ARBs: monitor blood pressure and electrolyte balance.
  • Corticosteroids: may potentiate fluid retention, requiring careful volume assessment.

Frequently Asked Questions

Natriumchloride Dirinco is an intravenous sodium chloride solution used to replace lost body fluids and correct electrolyte imbalances, such as low sodium or chloride levels, in patients who are dehydrated, bleeding, or otherwise experiencing hypovolemia.

The solution delivers sodium (Na⁺) and chloride (Cl⁻) ions directly into the bloodstream. These ions increase extracellular osmolarity, drawing water into the vascular compartment, which expands plasma volume and restores normal electrolyte concentrations.

The dose is individualized by the prescribing clinician based on the patient’s fluid status, electrolyte levels, and clinical condition. The prescriber determines the concentration, infusion rate, and total volume required for safe and effective therapy.

Safety data for this specific formulation in pregnancy and lactation are limited. Clinicians should weigh potential benefits against risks and consider alternative therapies when appropriate. Consultation with a specialist is recommended.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Natriumchloride Dirinco provides a simple isotonic sodium chloride solution, whereas other options may contain additional electrolytes, buffers, or colloids. Choice depends on the clinical scenario, desired electrolyte composition, and volume requirements as determined by the treating physician.

The product should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the container. Inspect for particulate matter before use and discard if the solution appears discolored.

It is administered intravenously, typically via a peripheral or central line. The infusion rate is set by the prescriber according to the patient’s fluid and electrolyte needs, and the solution may be given as a bolus or continuous infusion.

Serious risks include severe hypernatremia or hyperchloremia leading to metabolic acidosis, fluid overload causing pulmonary edema, and rare anaphylactic reactions. Continuous monitoring of vital signs, electrolytes, and fluid balance is essential.

Patients with known hypersensitivity to sodium chloride solutions, severe hypernatremia, or uncontrolled fluid overload should not receive this product. Clinicians must assess each individual’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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