Product image of Natriumcitrat Grifols (Sodium Citrate) supplied by GNH India

Natriumcitrat Grifols

Active Ingredient:
Sodium Citrate
Origin:
EU

Natriumcitrat Grifols (Sodium Citrate)

Sodium citrate, the active ingredient in Natriumcitrat Grifols, is an anticoagulant presented as a solution for extracorporeal use. It provides calcium chelation to prevent clot formation during procedures such as hemodialysis and plasma exchange.
GNH India supplies Natriumcitrat Grifols as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, dialysis centres, transplant centres and specialized clinics worldwide.

Manufacturer / TM Owner

Laboratorios Grifols, S.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Sodium citrate is employed as an anticoagulant in extracorporeal circuits and related renal replacement therapies.
  • Hemodialysis: maintains circuit patency by chelating calcium and preventing clot formation.
  • Continuous renal replacement therapy (CRRT): provides anticoagulation for prolonged dialysis sessions.
  • Plasma exchange: reduces clot risk during plasma apheresis procedures.

How It Works

  • Sodium citrate acts by binding ionized calcium in the blood, lowering free calcium concentrations that are essential for several steps of the coagulation cascade. This calcium chelation interrupts the activation of clotting factors, thereby inhibiting thrombus formation within extracorporeal circuits used for dialysis, apheresis, and related procedures.

Side Effects

Sodium citrate may cause several adverse reactions, ranging from mild to serious, depending on the extent of calcium depletion and individual sensitivity.

Common Side Effects

  • Hypocalcemia: transient low calcium levels causing tingling or muscle cramps.
  • Metallic taste in the mouth.
  • Nausea or mild gastrointestinal discomfort.
  • Vomiting.
  • Mild hypotension during infusion.

Serious or Rare Side Effects

  • Severe hypocalcemia leading to cardiac arrhythmia or seizures.
  • Allergic reactions such as rash, urticaria, or anaphylaxis.

Precautions & Warnings

  • When using sodium citrate, careful monitoring and specific precautions are recommended to ensure patient safety.
  • Patient monitoring: check ionized calcium levels regularly during treatment.
  • Electrolyte balance: assess for symptoms of hypocalcemia and correct as needed.
  • Renal function: consider dose adjustment in severe renal impairment.
  • Concurrent anticoagulants: avoid overlapping anticoagulant therapy without medical supervision.
  • Pregnancy and lactation: use only if the potential benefits justify the potential risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Sodium citrate can interact with other agents that affect calcium balance or coagulation pathways.

Major Interactions (Avoid)

  • Calcium supplements: counteract the anticoagulant effect of citrate.
  • Vitamin D analogues: may increase serum calcium and reduce efficacy.
  • Other anticoagulants (e.g., heparin, citrate‑containing solutions): risk of excessive anticoagulation.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may enhance calcium loss and potentiate hypocalcemia.
  • Beta‑agonists: potential additive hypotensive effect during infusion.

Frequently Asked Questions

Natriumcitrat Grifols contains sodium citrate and is used as an anticoagulant in extracorporeal medical procedures, such as hemodialysis, continuous renal replacement therapy, and plasma exchange, where preventing clot formation in the circuit is essential.

Sodium citrate chelates ionized calcium, a key cofactor in the clotting cascade. By lowering free calcium levels, it interrupts the activation of clotting factors, thereby inhibiting thrombus formation within extracorporeal circuits.

The dose of sodium citrate is individualized and determined by the prescribing clinician based on the specific procedure, patient weight, and laboratory monitoring of calcium levels. No fixed regimen is provided here.

Safety data are limited. Sodium citrate should only be used during pregnancy or lactation if the potential therapeutic benefit outweighs any possible risk to the mother or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Compared with heparin, sodium citrate offers regional anticoagulation without systemic effects, reducing bleeding risk. Unlike other citrate formulations, Natriumcitrat Grifols is specifically formulated for extracorporeal use, providing predictable calcium chelation and easy reversal by calcium supplementation if required.

The solution should be stored at ambient temperature, below 25 °C, in its original container. Protect it from moisture, direct sunlight and extreme temperature fluctuations to maintain stability and potency.

The product is added to the extracorporeal circuit as a sterile solution, typically via a dedicated infusion line. Administration is performed by trained healthcare personnel under continuous monitoring of ionized calcium and coagulation parameters.

The most serious risks include severe hypocalcemia, which can lead to cardiac arrhythmias, seizures, or hypotension, and rare allergic reactions such as anaphylaxis. Prompt recognition and treatment, including calcium replacement, are essential.

Patients with known hypersensitivity to sodium citrate, uncontrolled severe hypocalcemia, or those receiving overlapping systemic anticoagulants without medical supervision should not be treated with this product. Clinical judgment is required for each individual case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Sodium Citrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT