Natriumcromoglicat Micro Labs (Sodium Cromoglicate)

• Sodium cromoglicate eye drops act on ocular allergic pathways to relieve inflammation and irritation.
• Allergic conjunctivitis: reduces itching, redness, and watery discharge by stabilizing mast cells in the conjunctiva, leading to faster symptom relief and improved comfort.
• Seasonal allergic eye disease: prevents symptom flare‑ups during pollen seasons through inhibition of histamine release, helping patients maintain clear vision and reduced ocular irritation.
• Allergic keratoconjunctivitis: controls chronic ocular inflammation and improves visual comfort by limiting mast‑cell degranulation, thereby decreasing corneal staining and photophobia.

• Sodium cromoglicate acts as a mast‑cell stabilizer. When applied to the ocular surface, it penetrates conjunctival cells and binds to calcium channels, preventing intracellular calcium influx that triggers degranulation. By inhibiting the release of histamine, leukotrienes, and other inflammatory mediators, the drug reduces the cascade of allergic inflammation in the eye, thereby alleviating symptoms without systemic immunosuppression.

Sodium cromoglicate eye drops may cause local ocular reactions, although most patients tolerate the product well.

Common Side Effects

• Transient eye irritation or burning sensation that usually resolves within minutes after instillation.
• Mild itching or a foreign‑body feeling in the eye, often diminishing with continued use.
• Temporary blurred vision or slight visual disturbance that clears shortly after the drop is absorbed.

Serious or Rare Side Effects

• Severe allergic reaction presenting as marked eyelid swelling, redness, and possible hives around the ocular area.
• Persistent eye pain, significant reduction in visual acuity, or sudden loss of vision requiring immediate medical attention.
• Corneal ulceration or acute intraocular inflammation, which are rare but necessitate prompt ophthalmologic evaluation.

When using Sodium cromoglicate eye drops, certain precautions help ensure safety and effectiveness.

• Avoid use in patients with known hypersensitivity to sodium cromoglicate or any formulation excipients: discontinue immediately if reaction occurs.
• Do not apply to infected or inflamed ocular surfaces without physician guidance: infection may worsen.
• Contact lens wearers should remove lenses before instillation and wait several minutes before reinserting: reduces drug dilution.
• If systemic antihistamines are being used, monitor for reduced ocular efficacy: may require dosage adjustment.
• Store at below 25°C: keep in the original container, protect from light and moisture.

Sodium cromoglicate has a low systemic absorption profile, yet some ocular or systemic agents may influence its safety or efficacy.

Major Interactions (Avoid)

• Concurrent use of other mast‑cell stabilizer eye drops: may increase local irritation and reduce patient tolerance.
• Preservative‑containing ophthalmic solutions combined with this product: can potentiate ocular surface toxicity and exacerbate discomfort.

Moderate Interactions (Monitor Closely)

• Systemic antihistamines or corticosteroids: may alter the therapeutic response of sodium cromoglicate, requiring clinical observation.
• Contact lens solutions with high osmolarity or preservatives: could affect drug distribution and efficacy on the ocular surface.
• Topical ocular decongestants: may mask underlying allergic symptoms, leading to delayed recognition of adverse effects.