Product image of Natriumfluorid (18f) Nms (Sodium Fluoride (18f)) supplied by GNH India

Natriumfluorid (18f) Nms

Active Ingredient:
Sodium Fluoride (18f)
Origin:
EU

Natriumfluorid (18f) Nms (Sodium Fluoride (18f))

Sodium Fluoride, the active ingredient in Natriumfluorid (18f) Nms, is a radiopharmaceutical presented as a solution for injection for intravenous use. It is employed in bone imaging to detect metastatic disease and evaluate skeletal turnover in patients.

GNH India supplies Natriumfluorid (18f) Nms as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and imaging clinics worldwide.

Manufacturer / TM Owner

Norsk Medisinsk Syklotronsenter As

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Indications & Clinical Uses

Sodium Fluoride (18F) is a radiopharmaceutical used in bone imaging to assess skeletal metabolism and detect metastatic disease.

  • Bone metastasis detection: enables visualization of metastatic lesions in bone using PET imaging.
  • Skeletal imaging: provides high‑resolution images of the entire skeleton for diagnostic evaluation.
  • Evaluation of bone turnover: allows quantitative assessment of bone remodeling activity in research and clinical settings.

How It Works

  • After intravenous administration, the fluoride ion substitutes for hydroxyl groups in hydroxyapatite crystals, leading to selective accumulation in bone. The incorporated 18F isotope emits positrons, which are captured by PET scanners to generate detailed images of bone metabolism and pathology.

Side Effects

Sodium Fluoride (18F) is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Injection site pain: mild discomfort at the site of administration.
  • Nausea: transient feeling of queasiness after injection.
  • Flushing: brief warmth or redness of the skin.
  • Headache: mild to moderate headache reported by some patients.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Severe hypotension: marked drop in blood pressure following administration.
  • Radiation‑induced skin injury: localized skin changes at high exposure levels.

Precautions & Warnings

Use of Sodium Fluoride (18F) requires careful consideration of patient safety and handling of the radiopharmaceutical.

  • Pregnancy: avoid use unless clearly needed, as fetal radiation exposure is unknown.
  • Breastfeeding: discontinue breastfeeding for an appropriate period after administration.
  • Renal impairment: assess kidney function before dosing, as excretion is renal.
  • Radiation safety: follow local regulations for handling and disposal of radioactive material.
  • Hypersensitivity: do not administer to patients with known allergy to fluoride compounds.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium Fluoride (18F) may interact with other agents that affect bone metabolism or radiotracer distribution.

Major Interactions (Avoid)

  • Concurrent radiopharmaceuticals: may interfere with image interpretation.
  • High‑dose calcium supplements: can reduce tracer uptake in bone.
  • Certain chemotherapeutic agents (e.g., methotrexate): may alter bone turnover and affect imaging results.

Moderate Interactions (Monitor Closely)

  • Bisphosphonates: may modify bone binding of fluoride.
  • Corticosteroids: can influence bone metabolism and tracer distribution.
  • Iodinated contrast agents: may affect PET image quality if administered shortly before or after the tracer.

Frequently Asked Questions

Natriumfluorid (18f) Nms is a radiopharmaceutical containing Sodium Fluoride labeled with the positron‑emitting isotope Fluorine‑18. It is used primarily for PET imaging of the skeleton to detect bone metastases, perform whole‑body skeletal scans, and assess bone turnover in clinical and research settings.

After intravenous injection, the fluoride ion replaces hydroxyl groups in hydroxyapatite, concentrating in bone tissue. The attached 18F atom emits positrons that are captured by a PET scanner, producing high‑resolution images that reflect bone metabolism and the presence of pathological lesions.

The administered activity of Sodium Fluoride (18F) is determined by the prescribing physician or nuclear medicine specialist based on patient weight, the imaging protocol, and regulatory guidelines. Exact dosing is individualized and should follow local practice standards.

Safety data for Sodium Fluoride (18F) in pregnancy and lactation are limited. Use is generally avoided unless the diagnostic benefit outweighs potential risks to the fetus or infant. Physicians should discuss the risk‑benefit profile with the patient before proceeding.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Compared with traditional bone scintigraphy agents such as Technetium‑99m‑MDP, Sodium Fluoride (18F) offers higher image resolution, faster blood clearance, and shorter acquisition times on PET scanners. This can improve lesion detectability, especially for small or early metastatic deposits.

The product must be stored refrigerated at 2‑8 °C, protected from light, and never frozen or shaken. It should be handled in a designated radiopharmacy area using appropriate shielding and radiation safety procedures to protect personnel.

Sodium Fluoride (18F) is supplied as a sterile solution for injection and is administered intravenously by a qualified healthcare professional. After injection, imaging typically begins 30‑60 minutes later, depending on the specific protocol.

The most serious risks include severe allergic reactions such as anaphylaxis, marked hypotension, and radiation‑related tissue injury if handling guidelines are not followed. Prompt recognition and management of these events are essential.

Patients with known hypersensitivity to fluoride compounds, those who are pregnant or breastfeeding (unless the benefit outweighs risk), and individuals with severe renal impairment should avoid the tracer unless a specialist determines it is clinically necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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