Product image of Natriumhydrogencarbonat B. Braun (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumhydrogencarbonat B. Braun

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumhydrogencarbonat B. Braun (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumhydrogencarbonat B. Braun, is an electrolyte/alkalinizing agent presented as an injectable solution for intravenous use. It provides bicarbonate ions to buffer excess hydrogen ions, thereby raising systemic pH and correcting metabolic acidosis in acute care settings.

GNH India supplies Natriumhydrogencarbonat B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The product is manufactured in the European Union under stringent quality standards and is distributed through GNH India's global network.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Natriumhydrogencarbonat B. Braun is used to manage disorders of acid‑base balance by supplying bicarbonate.

  • Metabolic acidosis: raises blood pH and restores normal acid‑base status.
  • Hyperkalemia: promotes intracellular shift of potassium, helping lower serum potassium levels.
  • General acid‑base disorders: provides systemic buffering to correct pH abnormalities.
  • Urinary alkalinization: increases urinary pH to facilitate excretion of certain toxins or drugs.

How It Works

  • Sodium hydrogen carbonate dissociates after intravenous infusion, releasing bicarbonate ions that combine with hydrogen ions to form carbonic acid, which is then converted to CO₂ and water. This buffering reaction reduces hydrogen ion concentration, thereby increasing systemic pH and correcting metabolic acidosis. The added bicarbonate also promotes the intracellular movement of potassium, aiding in the management of hyperkalemia.

Side Effects

Adverse reactions may occur with intravenous sodium hydrogen carbonate administration.

Common Side Effects

  • Hypernatremia: elevated serum sodium levels.
  • Metabolic alkalosis: excessive rise in blood pH.
  • Fluid overload: volume expansion leading to edema.
  • Hypokalemia: reduced serum potassium.
  • Infusion site irritation: pain or erythema at the injection site.

Serious or Rare Side Effects

  • Severe metabolic alkalosis: can cause respiratory depression.
  • Pulmonary edema: accumulation of fluid in the lungs.
  • Anaphylactic reaction: rare but potentially life‑threatening hypersensitivity.
  • Severe hypernatremia: may result in neurological symptoms.
  • Thrombophlebitis: inflammation of a vein with clot formation.

Precautions & Warnings

Prior assessment and monitoring are essential when using intravenous sodium hydrogen carbonate.

  • Assess acid‑base status before administration: confirm presence of metabolic acidosis.
  • Monitor serum electrolytes: watch for hypernatremia, hypokalemia, and alkalosis.
  • Adjust dose in renal impairment: reduced clearance may increase bicarbonate accumulation.
  • Infuse at recommended rate: avoid rapid administration that could precipitate alkalosis.
  • Use with caution in heart failure: risk of fluid overload.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium hydrogen carbonate can interact with several agents; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Concurrent use of other alkalinizing agents (e.g., oral sodium bicarbonate): risk of severe metabolic alkalosis.
  • Co‑administration with hypertonic saline solutions: may cause marked hypernatremia.
  • Simultaneous infusion of calcium‑containing solutions: potential precipitation.
  • Use with mineral acids (e.g., ammonium chloride): antagonizes bicarbonate effect.

Moderate Interactions (Monitor Closely)

  • Concomitant loop diuretics: may exacerbate electrolyte shifts.
  • ACE inhibitors or ARBs: monitor potassium levels closely.
  • Certain antibiotics (e.g., aminoglycosides): renal clearance may be altered.
  • Insulin therapy: monitor glucose as bicarbonate can affect insulin sensitivity.

Frequently Asked Questions

Natriumhydrogencarbonat B. Braun is an intravenous sodium hydrogen carbonate solution used to correct metabolic acidosis, manage hyperkalemia, treat various acid‑base disorders, and alkalinize urine in hospitalized patients.

After IV infusion, sodium hydrogen carbonate dissociates into sodium and bicarbonate ions. The bicarbonate buffers excess hydrogen ions, forming carbonic acid that is rapidly converted to CO₂ and water, thereby raising systemic pH and correcting acidosis while also promoting intracellular potassium shift.

The dose is individualized by the prescribing clinician based on the patient’s acid‑base status, electrolyte levels, and clinical condition. Dosage calculations consider factors such as body weight, severity of acidosis, and renal function.

Safety data for sodium hydrogen carbonate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Natriumhydrogencarbonat B. Braun delivers sodium hydrogen carbonate directly into the bloodstream, offering rapid correction of acidosis compared with oral bicarbonate formulations. Unlike other agents such as tromethamine, it provides both sodium and bicarbonate, which may be advantageous in certain electrolyte management scenarios.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Prior to use, inspect the vial for particulate matter or discoloration and allow it to reach room temperature if required for infusion.

It is administered intravenously, typically via a peripheral or central line. The infusion rate and total volume are determined by the prescriber, who will base the regimen on the patient’s laboratory values and clinical response.

Serious risks include severe metabolic alkalosis, hypernatremia, pulmonary edema, and rare anaphylactic reactions. Continuous monitoring of blood pH, electrolytes, and fluid status is essential to detect and manage these complications promptly.

Patients with known hypersensitivity to sodium hydrogen carbonate, uncontrolled hypertension, severe congestive heart failure, or those at risk of fluid overload should not receive this product unless the benefits outweigh the risks and close monitoring is ensured.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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