Product image of Natriumhydrogencarbonat Fresenius (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumhydrogencarbonat Fresenius

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumhydrogencarbonat Fresenius (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumhydrogencarbonat Fresenius, is an electrolyte solution presented as a sterile solution for injection for intravenous use. It is employed to correct metabolic acidosis and to support resuscitation efforts in cardiac arrest and certain drug overdoses.
GNH India supplies Natriumhydrogencarbonat Fresenius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Natriumhydrogencarbonat Fresenius is used in clinical situations that require rapid correction of systemic acidity or alkalinization of bodily fluids.

  • Metabolic acidosis: restores normal pH by providing bicarbonate ions.
  • Cardiac arrest (resuscitation): assists in restoring circulatory function during emergency treatment.
  • Tricyclic antidepressant overdose: facilitates urinary alkalinization to enhance drug elimination.
  • Urinary alkalinization: adjusts urine pH for specific renal conditions or toxin clearance.

How It Works

  • Sodium hydrogen carbonate dissociates to release bicarbonate ions, which combine with hydrogen ions in the bloodstream, forming carbonic acid that is subsequently converted to carbon dioxide and water. This buffering action raises systemic pH, counteracting metabolic acidosis and providing an alkaline environment that can aid in drug elimination and cardiac resuscitation.

Side Effects

Administration of Natriumhydrogencarbonat Fresenius may be associated with several adverse reactions.

Common Side Effects

  • Injection site pain: mild discomfort at the infusion site.
  • Mild hypernatremia: slight elevation of serum sodium levels.
  • Metabolic alkalosis: over‑correction of pH in susceptible patients.
  • Hypokalemia: reduced serum potassium due to intracellular shift.

Serious or Rare Side Effects

  • Severe hypernatremia: marked increase in sodium causing neurologic symptoms.
  • Severe metabolic alkalosis: significant pH elevation leading to respiratory depression.
  • Pulmonary edema: fluid overload in patients with compromised cardiac function.
  • Anaphylaxis: rare hypersensitivity reaction requiring immediate intervention.

Precautions & Warnings

Prior to administration, clinicians should evaluate patient-specific factors and monitor relevant parameters.

  • Renal impairment: monitor serum electrolytes and acid‑base status closely.
  • Cardiac disease: watch for fluid overload and electrolyte shifts.
  • Pregnancy: use only when the potential benefit justifies the potential risk to the fetus.
  • Concomitant alkalinizing agents: avoid excessive alkalosis by adjusting doses.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium hydrogen carbonate can interact with other agents that affect electrolyte balance or acid‑base status.

Major Interactions (Avoid)

  • Calcium carbonate: may precipitate, reducing efficacy of both agents.
  • Hypertonic saline combined with sodium bicarbonate: increases risk of severe hypernatremia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may exacerbate potassium loss.
  • ACE inhibitors: can alter renal handling of sodium and bicarbonate.
  • Insulin therapy: may cause rapid intracellular potassium shifts.

Frequently Asked Questions

Natriumhydrogencarbonat Fresenius is an intravenous electrolyte solution used to correct metabolic acidosis, support cardiac resuscitation during arrest, aid in the treatment of certain drug overdoses such as tricyclic antidepressants, and to alkalinize urine for specific renal conditions.

Sodium hydrogen carbonate dissociates into sodium and bicarbonate ions. The bicarbonate acts as a buffer, binding excess hydrogen ions to form carbonic acid, which is then converted to carbon dioxide and water, thereby raising systemic pH and correcting acid‑base disturbances.

The dosage of Natriumhydrogencarbonat Fresenius is determined by the prescribing clinician based on the patient’s clinical condition, laboratory values, and therapeutic goals. Specific dosing regimens are not provided here and should follow the prescriber’s order.

Safety data for use in pregnancy and lactation are limited. The product should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Natriumhydrogencarbonat Fresenius provides rapid intravenous delivery of bicarbonate, which can be more immediate than oral agents. Compared with other intravenous alkalinizers, it offers a well‑characterized safety profile and is widely used in emergency and critical‑care settings for precise pH correction.

The solution should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Ensure the container remains sealed until use and handle according to standard aseptic techniques for injectable products.

It is administered intravenously by a qualified healthcare professional. The solution is typically infused slowly, with dosage and infusion rate determined by the prescriber based on the patient’s acid‑base status and clinical response.

Serious risks include severe hypernatremia, profound metabolic alkalosis, pulmonary edema, arrhythmias, and rare anaphylactic reactions. Continuous monitoring of electrolytes, blood gases, and hemodynamic status is essential during and after infusion.

Patients with known hypersensitivity to sodium bicarbonate, uncontrolled severe hypertension, untreated congestive heart failure, or those at high risk for fluid overload should not receive this product unless a careful risk‑benefit assessment justifies its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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