Product image of Natriumhydrogenkarbonat B. Braun (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumhydrogenkarbonat B. Braun

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumhydrogenkarbonat B. Braun (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumhydrogenkarbonat, is a Buffer / alkalinizing agent presented as a solution for injection for intravenous use. It is employed to correct metabolic acidosis and other acid‑base disturbances in hospitalized patients.

GNH India supplies Natriumhydrogenkarbonat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide. The product conforms to EU pharmacopeial standards, is manufactured under strict quality controls, and is available for global distribution with regulatory compliance.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Natriumhydrogenkarbonat is used as an intravenous buffer to manage acid‑base disorders.
  • Metabolic acidosis: restores normal blood pH by providing bicarbonate ions.
  • Urinary alkalinization: raises urinary pH to facilitate excretion of certain drugs or toxins.
  • Acid‑base disorders: corrects systemic acidemia in critical‑care settings.

How It Works

  • Sodium hydrogen carbonate dissociates in plasma to release bicarbonate ions, which combine with excess hydrogen ions to form carbonic acid. This reaction reduces hydrogen ion concentration, thereby raising systemic pH and correcting metabolic acidosis. The added bicarbonate also serves as a buffer, stabilizing acid‑base balance during intravenous administration.

Side Effects

Intravenous sodium hydrogen carbonate may be associated with several adverse reactions.

Common Side Effects

  • Hypernatremia: elevated serum sodium levels.
  • Metabolic alkalosis: excessive increase in blood pH.
  • Local infusion site irritation: pain or erythema at the injection site.
  • Hypokalemia: reduced serum potassium concentration.

Serious or Rare Side Effects

  • Severe metabolic alkalosis leading to respiratory depression.
  • Cardiac arrhythmias, especially in patients with electrolyte imbalance.
  • Pulmonary edema due to fluid overload.
  • Anaphylactic reaction: rare hypersensitivity response.

Precautions & Warnings

When using Natriumhydrogenkarbonat, clinicians should observe specific safety measures.

  • Renal impairment: monitor serum bicarbonate and electrolytes closely.
  • Cardiac disease: avoid rapid infusion in patients with heart failure.
  • Fluid overload risk: adjust infusion volume in patients with edema.
  • Electrolyte monitoring: check potassium and sodium levels during therapy.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium hydrogen carbonate can interact with other medications, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Concurrent alkalinizing agents (e.g., sodium citrate): may cause severe alkalosis.
  • Loop diuretics that promote potassium loss: can exacerbate hypokalemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may increase risk of hyperkalemia when combined with potassium‑sparing effects.
  • NSAIDs: can affect renal handling of sodium and bicarbonate.
  • Calcium channel blockers: monitor blood pressure during rapid infusion.
  • Antacids containing bicarbonate: additive effect on systemic pH.

Frequently Asked Questions

Natriumhydrogenkarbonat is an intravenous solution of sodium hydrogen carbonate used primarily to correct metabolic acidosis, to alkalinize urine for certain therapeutic purposes, and to manage other acid‑base disturbances in hospitalized patients.

When administered intravenously, sodium hydrogen carbonate dissociates into sodium and bicarbonate ions. The bicarbonate binds excess hydrogen ions, forming carbonic acid, which is then converted to water and carbon dioxide, thereby raising blood pH and restoring acid‑base balance.

The dose of Natriumhydrogenkarbonat is determined by the prescribing clinician based on the patient’s clinical condition, laboratory values, and therapeutic goals. Specific dosing regimens are not provided here and should follow the prescriber’s instructions.

Safety data for sodium hydrogen carbonate in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Natriumhydrogenkarbonat provides direct bicarbonate ions, offering rapid correction of acidosis, whereas other agents such as sodium citrate require metabolic conversion to bicarbonate. This direct mechanism often results in a faster pH response but may require closer electrolyte monitoring.

The product should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Follow the manufacturer’s packaging instructions to maintain sterility and potency.

Natriumhydrogenkarbonat is administered intravenously by slow infusion under clinical supervision. The infusion rate and concentration are adjusted according to the patient’s acid‑base status and electrolyte levels, as directed by the healthcare professional.

Serious risks include severe metabolic alkalosis, which can depress respiration, cardiac arrhythmias due to electrolyte disturbances, pulmonary edema from fluid overload, and rare anaphylactic reactions. Continuous monitoring of blood gases and electrolytes is essential.

Patients with uncontrolled hypernatremia, severe renal failure, uncompensated heart failure, or known hypersensitivity to sodium bicarbonate should not receive this product unless a physician determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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