Product image of Natriumjodid [123i] Ge Healthcare (Sodium Iodide (123 I)) supplied by GNH India

Natriumjodid [123i] Ge Healthcare

Active Ingredient:
Sodium Iodide (123 I)
Origin:
EU

Natriumjodid [123i] Ge Healthcare (Sodium Iodide (123 I))

Sodium Iodide (I-123), the active ingredient in Natriumjodid [123i] Ge Healthcare, is a radiopharmaceutical presented as a solution for injection for intravenous use. It is used for diagnostic imaging of thyroid function and morphology in patients requiring thyroid scintigraphy, evaluation of nodules, or detection of metastatic disease.

GNH India supplies Natriumjodid [123i] Ge Healthcare as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ge Healthcare B.V.

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Indications & Clinical Uses

Natriumjodid [123i] Ge Healthcare is a radiopharmaceutical that targets thyroid tissue for diagnostic imaging.

  • Thyroid scintigraphy: enables visualization of thyroid uptake to assess function and anatomy.
  • Evaluation of thyroid nodules: helps differentiate benign from malignant nodules based on iodine uptake patterns.
  • Detection of metastatic thyroid cancer: identifies iodine‑avid metastatic lesions throughout the body.

How It Works

  • Sodium Iodide I-123 is taken up by thyroid follicular cells via the sodium‑iodide symporter. Once inside the cells, the isotope emits gamma photons that are detected by a gamma camera, producing high‑resolution images of thyroid tissue distribution and allowing functional and anatomical assessment without significant beta radiation exposure.

Side Effects

Adverse reactions are generally infrequent but may occur after administration of the radiopharmaceutical.

Common Side Effects

  • Nausea: mild and transient.
  • Headache: mild discomfort shortly after injection.
  • Warmth or flushing at the injection site.
  • Transient metallic taste.

Serious or Rare Side Effects

  • Allergic reaction: rash, urticaria, or anaphylaxis.
  • Hypersensitivity: bronchospasm or angioedema.
  • Radiation‑induced thyroiditis: inflammation of thyroid tissue presenting with pain or swelling.
  • Severe hypotension: rare but possible during rapid injection.
  • Hematologic changes: transient leukopenia or thrombocytopenia in very high exposures.

Precautions & Warnings

Prior to use, several safety considerations should be observed.

  • Pregnancy: unknown risk; avoid unless essential for diagnosis.
  • Breastfeeding: unknown safety; consider alternative imaging.
  • Thyroid function: assess baseline function to interpret results accurately.
  • Radiation safety: follow ALARA principles and protect staff and family members.
  • Renal impairment: monitor because excretion may be delayed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium Iodide I-123 may interact with other agents that affect iodine handling or thyroid imaging.

Major Interactions (Avoid)

  • Iodine‑containing contrast agents: can block thyroid uptake and compromise imaging.
  • Antithyroid drugs (methimazole, propylthiouracil): reduce tracer accumulation.
  • Lithium: alters iodine transport and may affect image quality.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement therapy: may influence interpretation of uptake patterns.
  • Amiodarone: high iodine load can interfere with tracer distribution.
  • Diuretics: may affect renal clearance of the radiotracer.

Frequently Asked Questions

Natriumjodid [123i] Ge Healthcare is a diagnostic radiopharmaceutical containing Sodium Iodide I-123. It is administered in nuclear medicine to image thyroid tissue, helping clinicians assess thyroid function, characterize nodules, and locate metastatic thyroid cancer.

Sodium Iodide I-123 is selectively taken up by thyroid follicular cells via the sodium‑iodide symporter. The isotope emits gamma radiation that is captured by a gamma camera, producing detailed images of thyroid distribution and allowing functional evaluation.

The administered activity is determined by the prescribing nuclear medicine physician based on patient weight, age, and the specific imaging protocol. Dosing is individualized and not standardized in public literature.

Safety data for use during pregnancy and lactation are limited. The product is generally avoided unless the diagnostic benefit outweighs potential radiation exposure to the fetus or infant.

Enquiries are submitted through the product page at gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Compared with I‑131, I‑123 provides superior image quality with a lower radiation dose, and it offers better specificity than Tc‑99m pertechnetate for thyroid imaging. This makes it a preferred choice for detailed functional studies.

Store the solution at 2‑8 °C, protect it from light, keep it in the original container, and avoid freezing or shaking. Handle the product using standard radiation safety precautions and aseptic technique.

Natriumjodid is supplied as a sterile aqueous solution for intravenous injection. It is administered by a qualified healthcare professional under aseptic conditions, typically as a single bolus or slow infusion according to the imaging protocol.

Serious adverse reactions include allergic or anaphylactic responses and radiation‑induced thyroiditis. Patients should be monitored for signs of hypersensitivity, unexpected thyroid inflammation, or severe hypotension during and after administration.

Contraindications include known hypersensitivity to iodine or iodide compounds, pregnant or nursing women when the diagnostic benefit is not essential, and patients in whom radiation exposure is contraindicated due to underlying conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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