Product image of Natriumjodid (131i) Diagnostikkapseln Ge Healthcare (Sodium Iodide (131i)) supplied by GNH India

Natriumjodid (131i) Diagnostikkapseln Ge Healthcare

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Natriumjodid (131i) Diagnostikkapseln Ge Healthcare (Sodium Iodide (131i))

Sodium Iodide, the active ingredient in Natriumjodid (131i) Diagnostikkapseln, is a diagnostic radiopharmaceutical presented as a capsule for oral use. It is employed to image thyroid tissue and assess thyroid function in patients undergoing diagnostic evaluation.

GNH India supplies Natriumjodid (131i) Diagnostikkapseln as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The product conforms to EU regulatory standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Ge Healthcare Buchler Gmbh & Co. Kg

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Indications & Clinical Uses

  • Natriumjodid (131i) Diagnostikkapseln is a radioactive iodine preparation used in thyroid imaging and functional assessment.
  • Thyroid imaging: enables visualization of thyroid anatomy and iodine uptake for diagnostic interpretation.
  • Hyperthyroidism evaluation: helps quantify functional activity of overactive thyroid tissue to guide management.
  • Thyroid nodule assessment: differentiates benign from malignant nodules based on iodine uptake patterns.

How It Works

  • Sodium Iodide (I‑131) is actively transported into thyroid follicular cells via the sodium‑iodide symporter. Once inside, the radioactive iodine emits gamma photons that are detected by scintigraphic cameras, producing images of iodine distribution. The emitted beta particles also provide a therapeutic dose, but at diagnostic levels the primary purpose is imaging. The selective uptake allows precise assessment of thyroid tissue function and morphology.

Side Effects

Administration of I‑131 sodium iodide may be associated with several adverse reactions, ranging from mild, transient symptoms to rare but serious radiation‑related events.

Common Side Effects

  • Nausea: mild, transient feeling of sickness.
  • Abdominal discomfort: mild pain or cramping in the stomach area.
  • Taste alteration: temporary metallic or altered taste perception.
  • Headache: mild, transient head pain.

Serious or Rare Side Effects

  • Allergic reaction (anaphylaxis): severe hypersensitivity that may require emergency treatment.
  • Radiation thyroiditis: inflammation of thyroid tissue due to radiation exposure.
  • Bone marrow suppression (rare): decreased blood cell production, potentially leading to anemia or infection.
  • Pulmonary radiation pneumonitis (very rare): inflammation of lung tissue after high radiation exposure.

Precautions & Warnings

Prior to using Natriumjodid (131i) Diagnostikkapseln, several safety considerations should be observed.

  • Pregnancy: avoid use unless clearly indicated, as fetal radiation exposure is possible.
  • Breastfeeding: discontinue product and consider alternative imaging; iodine can be secreted in milk.
  • Thyroid function: assess baseline thyroid status before administration to interpret results accurately.
  • Renal impairment: evaluate kidney function, as excretion may be altered.
  • Radiation safety: limit exposure of staff and family members; follow institutional radiation protection guidelines.
  • Store at ambient temperature: keep capsules in original packaging, protect from moisture and light.

Avoid Interactions

I‑131 sodium iodide can interact with other agents that affect iodine metabolism or radiation exposure.

Major Interactions (Avoid)

  • Concomitant radioactive iodine therapy: cumulative radiation dose may exceed safety limits.
  • High‑dose levothyroxine therapy: suppresses thyroid uptake, reducing diagnostic efficacy.

Moderate Interactions (Monitor Closely)

  • Antithyroid drugs (methimazole, propylthiouracil): may decrease iodine uptake, affecting image quality.
  • Iodinated contrast agents: can interfere with thyroid uptake if administered within two weeks.
  • Lithium therapy: alters thyroid iodine handling, potentially modifying imaging results.

Frequently Asked Questions

Natriumjodid (131i) Diagnostikkapseln is used as a diagnostic radiopharmaceutical to image the thyroid gland and assess its functional activity. The radioactive iodine it contains is taken up by thyroid tissue, allowing clinicians to evaluate conditions such as hyperthyroidism, thyroid nodules, and overall gland morphology through scintigraphic imaging.

Sodium Iodide labeled with I‑131 is selectively absorbed by thyroid follicular cells via the sodium‑iodide symporter. Once inside the cells, the isotope emits gamma photons that are captured by a gamma camera, producing detailed images of iodine distribution within the gland. This selective uptake provides a clear picture of thyroid function and anatomy.

The administered activity of Natriumjodid (131i) Diagnostikkapseln is determined by the prescribing physician based on the specific diagnostic indication, patient age, weight, and the imaging protocol of the nuclear medicine department. Dosage is individualized and should follow local regulatory guidelines and the institution’s radiation safety standards.

Use of I‑131 sodium iodide during pregnancy is generally avoided because the radiation can cross the placenta and affect the fetus. In breastfeeding women, iodine can be secreted into breast milk, potentially exposing the infant. Therefore, the product should only be used if the benefit outweighs the risk and alternative imaging methods are not suitable.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Natriumjodid (131i) Diagnostikkapseln. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After validation, the sales team provides pricing, availability, shipping details and assists with any necessary import documentation.

Natriumjodid (131i) provides both diagnostic imaging and a low therapeutic radiation dose, whereas non‑radioactive agents such as ultrasound offer structural information only. Compared with technetium‑99m pertechnetate, I‑131 has a longer half‑life and higher thyroid uptake, giving clearer functional images but requiring stricter radiation safety measures.

Store the capsules at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct light, and ensure the packaging remains sealed until use. Do not refrigerate or freeze the product, as temperature extremes can affect capsule integrity.

The product is administered orally as a capsule. The patient swallows the capsule with water under the supervision of qualified nuclear medicine staff. After ingestion, a waiting period allows the iodine to concentrate in the thyroid before imaging is performed, typically ranging from a few hours to a day depending on the protocol.

Serious risks include allergic reactions such as anaphylaxis, radiation‑induced thyroiditis, and, rarely, bone marrow suppression due to systemic radiation exposure. Patients should be monitored for signs of hypersensitivity, persistent neck pain, or unexplained hematologic abnormalities, and any severe symptoms should prompt immediate medical evaluation.

The product should be avoided in pregnant women, nursing mothers, and patients with known hypersensitivity to iodine or radioactive substances. Individuals with severe uncontrolled thyroid disorders, recent exposure to high‑dose radioactive iodine therapy, or those unable to comply with radiation safety precautions should also be excluded.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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