Product image of Natriumjodid (I-123) Curium Netherlands (Sodium Iodide (123 I)) supplied by GNH India

Natriumjodid (I-123) Curium Netherlands

Active Ingredient:
Sodium Iodide (123 I)
Origin:
EU

Natriumjodid (I-123) Curium Netherlands (Sodium Iodide (123 I))

Sodium Iodide (I-123), the active ingredient in Natriumjodid (I-123) Curium Netherlands, is a radiopharmaceutical presented as a sterile solution for intravenous use. It is employed for diagnostic imaging of thyroid function and anatomy in patients undergoing thyroid scintigraphy and related evaluations.

GNH India supplies Natriumjodid (I-123) Curium Netherlands as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Sodium Iodide (I-123) is used in nuclear medicine for thyroid imaging, allowing assessment of thyroid function and structure.

  • Thyroid scintigraphy: provides functional images of thyroid tissue to evaluate uptake patterns.
  • Hyperthyroidism evaluation: helps differentiate causes of excess thyroid hormone production.
  • Thyroid nodule assessment: assists in characterising nodules as benign or malignant based on iodine uptake.

How It Works

  • After intravenous injection, Sodium Iodide (I-123) is actively transported into thyroid follicular cells via the sodium‑iodide symporter. The isotope emits gamma photons that are detected by a gamma camera, producing high‑resolution images that reflect the functional activity and anatomical distribution of thyroid tissue.

Side Effects

Adverse reactions may occur following administration of Sodium Iodide (I-123).

Common Side Effects

  • Mild nausea
  • Transient flushing
  • Headache
  • Injection‑site discomfort

Serious or Rare Side Effects

  • Allergic reaction, including anaphylaxis
  • Radiation‑induced thyroiditis
  • Severe hypotension

Precautions & Warnings

Use of Sodium Iodide (I-123) requires careful consideration of patient‑specific factors and handling requirements.

  • Pregnancy: administer only if the diagnostic benefit outweighs potential fetal radiation risk.
  • Breastfeeding: consider temporary cessation of nursing or use of expressed milk.
  • Baseline thyroid function: assess uptake baseline before tracer administration.
  • Concurrent iodine therapy: avoid high‑dose iodide within 24 hours of the procedure.
  • Radiation safety: follow institutional protocols for shielding, waste disposal, and personnel monitoring.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium Iodide (I-123) may interact with other agents that affect iodine handling or thyroid physiology.

Major Interactions (Avoid)

  • High‑dose iodide therapy: reduces tracer uptake and compromises image quality.
  • Thyroid blocking agents (e.g., perchlorate): prevent tracer accumulation in thyroid tissue.

Moderate Interactions (Monitor Closely)

  • Antithyroid drugs (methimazole, propylthiouracil): may alter iodine uptake dynamics.
  • Lithium therapy: can increase thyroid retention of the tracer.
  • Recent contrast agents (within 24 h): may interfere with imaging results.

Frequently Asked Questions

Sodium Iodide (I-123) is a radiopharmaceutical used primarily for thyroid scintigraphy, a diagnostic imaging technique that visualises thyroid tissue function and anatomy. It helps clinicians evaluate conditions such as hyperthyroidism, hypothyroidism, and thyroid nodules by showing how the gland takes up iodine.

After intravenous injection, the I-123 isotope is taken up by thyroid cells via the sodium‑iodide symporter. The radioactive decay of I-123 emits gamma photons that are captured by a gamma camera, producing detailed images that reflect the functional activity of the thyroid gland.

The administered activity of Sodium Iodide (I-123) is determined by the prescribing physician or nuclear medicine specialist based on the specific diagnostic protocol, patient size, and equipment sensitivity. Exact dosing is individualized and should follow local regulatory and institutional guidelines.

Sodium Iodide (I-123) should only be used in pregnancy when the diagnostic benefit justifies the potential radiation risk to the fetus. For breastfeeding mothers, temporary suspension of nursing or provision of expressed milk is recommended until the radioactivity has sufficiently cleared, as advised by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Compared with I-131, I-123 emits lower‑energy gamma photons, resulting in higher‑resolution images and reduced radiation dose to the patient. Unlike technetium‑99m pertechnetate, I-123 is actively organified within the thyroid, providing more accurate functional information for certain diagnostic scenarios.

The product must be stored refrigerated at 2‑8 °C, protected from light, and never frozen or shaken. It should be handled in a shielded environment by trained personnel, following radiation safety protocols to minimise exposure to staff and the environment.

Sodium Iodide (I-123) is administered intravenously as a sterile solution. The injection is performed by qualified healthcare professionals in a nuclear medicine suite, after confirming patient identity, baseline thyroid function and any contraindications.

Serious risks include allergic reactions that can progress to anaphylaxis, radiation‑induced thyroiditis, and severe hypotension. These events are rare but require immediate medical attention. Institutions should have emergency protocols and appropriate resuscitation equipment readily available.

Patients with known hypersensitivity to iodine‑based radiopharmaceuticals, those who have received high‑dose iodide therapy within the preceding 24 hours, or individuals for whom radiation exposure poses an unacceptable risk (e.g., certain pregnant patients) should not receive Sodium Iodide (I-123) unless a clear clinical benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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