Product image of Natriumjodid (I-131) Curiumpharma (Sodium Iodide (131i)) supplied by GNH India

Natriumjodid (I-131) Curiumpharma

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Natriumjodid (I-131) Curiumpharma (Sodium Iodide (131i))

Sodium Iodide I-131, the active ingredient in Natriumjodid (I-131) Curiumpharma, is a radioactive iodine presented as an oral solution for oral use. It is employed in the management of hyperthyroidism, thyroid cancer and for thyroid tissue ablation in adult patients.

GNH India supplies Natriumjodid (I-131) Curiumpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation to support import and clinical use.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Natriumjodid (I-131) is a radioactive iodine used in the thyroid disease treatment pathway.

  • Hyperthyroidism: reduces thyroid hormone production by destroying overactive thyroid cells, helping to achieve euthyroidism.
  • Thyroid cancer: eliminates residual thyroid tissue after thyroidectomy, improving disease control and facilitating postoperative monitoring.
  • Thyroid ablation: prepares patients for diagnostic radioactive iodine scanning or reduces thyroid tissue prior to other therapeutic interventions, enhancing treatment precision.

How It Works

  • Sodium Iodide I-131 is selectively taken up by thyroid follicular cells via the sodium‑iodide symporter. Once inside the gland, the emitted beta particles deliver localized radiation that damages cellular DNA, leading to apoptosis of thyroid tissue while sparing surrounding structures.

Side Effects

Oral administration of sodium iodide I-131 may be associated with a range of adverse reactions.

Common Side Effects

  • Nausea
  • Vomiting
  • Dry mouth
  • Altered taste perception
  • Neck tenderness
  • Mild fever

Serious or Rare Side Effects

  • Severe hypothyroidism
  • Radiation thyroiditis
  • Bone marrow suppression
  • Anaphylactic allergic reaction
  • Pulmonary fibrosis (very rare)

Precautions & Warnings

Before prescribing Natriumjodid (I-131), clinicians should consider several safety measures.

  • Pregnancy: avoid use unless clearly needed, as fetal thyroid may be affected.
  • Breastfeeding: discontinue breastfeeding during treatment and for a defined period after.
  • Thyroid function: assess baseline thyroid hormone levels before administration.
  • Concurrent thyroid medication: adjust antithyroid drugs as they may reduce iodine uptake.
  • Radiation safety: follow local regulations for handling and disposal of radioactive material.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Natriumjodid (I-131) can interact with several medications and substances that influence iodine metabolism.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., methimazole, propylthiouracil) reduce iodine uptake.
  • Lithium therapy interferes with thyroid function and iodine uptake.
  • High dietary iodine (iodine supplements, contrast agents) decreases effectiveness.

Moderate Interactions (Monitor Closely)

  • Levothyroxine may require dose adjustment after ablation.
  • Corticosteroids can affect radiation response.
  • Certain chemotherapy agents may increase bone marrow toxicity.

Frequently Asked Questions

Natriumjodid (I-131) is a radioactive iodine preparation used to treat hyperthyroidism, to ablate residual thyroid tissue after thyroid cancer surgery, and to prepare patients for diagnostic or therapeutic radioactive iodine procedures. It works by delivering targeted radiation to thyroid cells, helping to control hormone production or eliminate malignant tissue.

Sodium Iodide I-131 is taken up by thyroid cells through the sodium‑iodide symporter. Inside the gland, the I-131 isotope emits beta radiation that damages cellular DNA, causing selective destruction of thyroid tissue while minimizing exposure to surrounding organs.

The prescribed dose of Natriumjodid (I-131) is individualized by the treating physician based on factors such as the specific indication, thyroid gland size, iodine uptake studies, patient weight, and overall clinical condition. No standard dosing can be provided without a medical assessment.

Use of radioactive iodine is generally contraindicated in pregnancy because the fetus’s thyroid can be damaged. Breastfeeding should be discontinued during treatment and for a period recommended by the physician, as the drug can be secreted in milk and affect the infant’s thyroid.

To order Natriumjodid (I-131), submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Non‑radioactive iodine supplements provide dietary iodine but do not deliver therapeutic radiation. Natriumjodid (I-131) combines iodine uptake with beta radiation, allowing selective destruction of thyroid tissue, which is essential for conditions like hyperthyroidism and post‑surgical thyroid cancer ablation where simple supplementation is ineffective.

Store Natriumjodid (I-131) at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, light, and physical damage, and ensure that it is stored out of reach of unauthorized personnel.

Natriumjodid (I-131) is administered orally, typically as a single dose in liquid or capsule form, under the supervision of a qualified healthcare professional. The patient may be instructed to fast before and after dosing to optimize thyroid uptake of the radioactive iodine.

Serious risks include severe hypothyroidism requiring lifelong hormone replacement, radiation‑induced thyroiditis, bone marrow suppression leading to cytopenias, and rare allergic reactions such as anaphylaxis. Long‑term monitoring of thyroid function and blood counts is essential after therapy.

Patients with known hypersensitivity to iodine or radioactive iodine, pregnant women, nursing mothers (unless the benefit outweighs risk), and individuals with uncontrolled severe cardiac disease or active infection should generally avoid Natriumjodid (I-131). Final eligibility must be determined by the prescribing physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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