Product image of Natriumjodid (I-131) Ge Healthcare (Sodium Iodide (131i)) supplied by GNH India

Natriumjodid (I-131) Ge Healthcare

Active Ingredient:
Sodium Iodide (131i)
Origin:
EU

Natriumjodid (I-131) Ge Healthcare (Sodium Iodide (131i))

Sodium Iodide I-131, the active ingredient in Natriumjodid (I-131), is a radioactive iodine presented as a radiopharmaceutical for oral use. It is employed in diagnostic imaging and therapeutic ablation of thyroid tissue, primarily in patients with thyroid disorders such as hyperthyroidism or differentiated thyroid cancer.

GNH India supplies Natriumjodid (I-131) as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Ge Healthcare Buchler Gmbh & Co. Kg

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Indications & Clinical Uses

Natriumjodid (I-131) is used in the management of thyroid‑related conditions where radioactive iodine uptake is required.

  • Thyroid imaging: enables visualization of thyroid tissue distribution for diagnostic assessment.
  • Thyroid ablation: delivers localized radiation to destroy overactive or residual thyroid cells after surgery.
  • Treatment of hyperthyroidism: reduces hormone production by selectively irradiating hyperfunctioning thyroid tissue.

How It Works

  • Sodium Iodide I-131 is actively taken up by thyroid follicular cells via the sodium‑iodide symporter. Once inside the gland, the emitted beta particles cause localized cellular damage, while gamma emissions allow external imaging. This dual action provides both diagnostic visualization and therapeutic ablation of thyroid tissue without affecting surrounding structures.

Side Effects

Adverse reactions may occur following oral administration of radioactive iodine.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal discomfort.
  • Dry mouth: reduced salivary flow after uptake.
  • Taste alteration: temporary metallic or bitter taste sensation.
  • Fatigue: transient tiredness during the first few days.
  • Mild thyroid pain: localized discomfort in the neck region.

Serious or Rare Side Effects

  • Salivary gland inflammation: painful swelling requiring medical attention.
  • Severe allergic reaction: rash, itching, or anaphylaxis.
  • Bone marrow suppression: rare decrease in blood cell counts.
  • Pulmonary fibrosis: extremely rare lung tissue scarring.
  • Secondary malignancy: long‑term risk of radiation‑induced cancers.

Precautions & Warnings

Use of Natriumjodid (I-131) requires careful consideration of patient factors and handling procedures.

  • Pregnancy: avoid use unless clearly needed, as fetal thyroid can be affected.
  • Breastfeeding: discontinue breastfeeding for an appropriate period after administration.
  • Renal impairment: adjust monitoring as reduced clearance may increase exposure.
  • Thyroiditis: assess risk of exacerbating inflammation.
  • Radiation safety: follow local regulations for handling and disposal of radioactive material.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and direct sunlight.

Avoid Interactions

Radioactive iodine can interact with other agents that affect iodine metabolism or radiation exposure.

Major Interactions (Avoid)

  • Antithyroid drugs (e.g., methimazole, propylthiouracil): may block iodine uptake, reducing efficacy.
  • High‑dose potassium iodide: competitively inhibits sodium‑iodide symporter, diminishing uptake.

Moderate Interactions (Monitor Closely)

  • Lithium: can alter thyroid function and iodine handling, requiring thyroid function monitoring.
  • Amiodarone: contains large iodine load, may interfere with radioiodine distribution.
  • Diuretics: may affect renal clearance of iodine, necessitating dose adjustment.

Frequently Asked Questions

Natriumjodid (I-131) is a radioactive iodine preparation used primarily for thyroid imaging, thyroid tissue ablation after surgery, and the treatment of hyperthyroidism. It exploits the thyroid’s natural ability to concentrate iodine, allowing both diagnostic visualization and therapeutic radiation delivery to thyroid cells.

Sodium Iodide I-131 is absorbed by thyroid follicular cells via the sodium‑iodide symporter. Inside the gland, the isotope emits beta particles that cause localized cellular damage, while gamma emissions enable external imaging. This selective uptake provides targeted therapy and diagnostic information without affecting surrounding tissues.

The prescribed dose of Natriumjodid (I-131) is determined by the treating physician based on the specific indication, patient weight, thyroid size, and intended therapeutic goal. Dosing is individualized and should follow the prescriber’s written order and local radiation safety guidelines.

Radioactive iodine is generally contraindicated in pregnancy because it can cross the placenta and affect fetal thyroid development. Breastfeeding should be paused for a period recommended by the prescribing physician to avoid iodine transfer to the infant. Consultation with a specialist is essential before use in these situations.

To request Natriumjodid (I-131), submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with non‑radioactive therapies such as antithyroid drugs or surgical removal, Natriumjodid (I-131) offers a non‑invasive, targeted approach that can both image and ablate thyroid tissue in a single administration. It avoids the risks of surgery and provides precise dosing, but requires adherence to radiation safety protocols.

Natriumjodid (I-131) should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight, and physical damage. Follow local regulations for handling radioactive materials, including proper labeling and disposal of any waste.

The product is administered orally, usually as a single dose in capsule or liquid form, under the supervision of a qualified physician. Patients may be instructed to fast before and after dosing to optimize thyroid uptake, and radiation safety guidelines are observed for both patient and staff.

Serious risks include salivary gland inflammation, severe allergic reactions, bone marrow suppression, and, rarely, secondary malignancies due to radiation exposure. Patients should be monitored for signs of these events, and any severe symptoms should prompt immediate medical evaluation.

Contraindications include pregnant women, nursing mothers (unless discontinued for the recommended interval), patients with severe iodine allergy, and individuals with uncontrolled thyroiditis. Additionally, patients unable to comply with radiation safety measures should not receive this radiopharmaceutical.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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