Product image of Natriumkromoglikat Abece (Sodium Cromoglicate) supplied by GNH India

Natriumkromoglikat Abece

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Natriumkromoglikat Abece (Sodium Cromoglicate)

Sodium cromoglicate, the active ingredient in Natriumkromoglikat Abece, is a mast cell stabilizer presented as an ophthalmic solution for ocular use. It is employed to treat allergic conjunctivitis and vernal keratoconjunctivitis, helping to reduce eye itching, redness, and swelling in patients with allergic eye disease.

GNH India supplies Natriumkromoglikat Abece as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows EU GMP standards and provides reliable, temperature‑controlled logistics for global distribution.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Sodium cromoglicate is used in ophthalmology to manage allergic eye conditions by stabilizing mast cells.

  • Allergic conjunctivitis: reduces ocular itching, redness and swelling.
  • Vernal keratoconjunctivitis: prevents mast cell degranulation and improves chronic symptoms.
  • Seasonal allergic eye disease: stabilizes mast cells to lessen inflammation and discomfort.

How It Works

  • Sodium cromoglicate binds to calcium channels on mast cells, inhibiting calcium influx that is required for degranulation. By preventing the release of histamine, leukotrienes, and other inflammatory mediators, it stabilizes the ocular surface and reduces the cascade of allergic inflammation that leads to itching, redness, and swelling.

Side Effects

Adverse ocular and systemic reactions have been reported with sodium cromoglicate eye drops.

Common Side Effects

  • Eye irritation: mild burning or stinging on instillation.
  • Blurred vision: temporary visual disturbance after dosing.
  • Taste disturbance: bitter taste when solution drains through nasolacrimal duct.
  • Headache: mild headache in some patients.
  • Ocular discomfort: sensation of foreign body.

Serious or Rare Side Effects

  • Severe allergic reaction: angioedema or anaphylaxis requiring immediate medical attention.
  • Eye infection: bacterial or fungal infection secondary to compromised ocular surface.
  • Corneal ulcer: rare ulceration that may threaten vision.
  • Vision loss: abrupt loss of visual acuity, urgent evaluation needed.
  • Persistent redness: prolonged inflammation indicating possible complication.

Precautions & Warnings

When prescribing sodium cromoglicate eye drops, consider the following precautions to ensure safe use.

  • Assess patient history: check for known hypersensitivity to sodium cromoglicate or formulation excipients.
  • Avoid concurrent ocular surgery: discontinue use prior to procedures to prevent interference with healing.
  • Monitor for ocular irritation: advise patients to report persistent burning or redness.
  • Use with caution in children: pediatric safety data are limited; evaluate risk‑benefit.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Sodium cromoglicate may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Preservative‑rich antihistamine drops: may increase ocular irritation.
  • Topical corticosteroids: concurrent use can mask signs of infection.
  • Multiple mast cell stabilizers: no added benefit and may heighten local discomfort.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines: may reduce tear production, monitor for dry eye.
  • Contact lens wear: lenses can trap the solution, advise removal during treatment.

Frequently Asked Questions

Natriumkromoglikat Abece contains sodium cromoglicate and is indicated for the treatment of allergic conjunctivitis and vernal keratoconjunctivitis. It works by stabilising ocular mast cells, thereby reducing itching, redness, swelling and other inflammatory symptoms associated with allergic eye disease.

Sodium cromoglicate blocks calcium entry into mast cells, which prevents the cells from releasing histamine, leukotrienes and other inflammatory mediators. By inhibiting this degranulation process, the drug reduces the allergic cascade on the ocular surface, leading to relief of itching, redness and swelling.

The dosing regimen for Natriumkromoglikat Abece is determined by the prescribing clinician based on the severity of the allergic eye condition, patient age and response to therapy. The prescriber will specify the number of drops, frequency and duration appropriate for each individual case.

Safety data for sodium cromoglicate eye drops during pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any unknown risks and discuss the decision with the patient. Use only if clearly indicated and prescribed by a qualified professional.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and the necessary import documentation.

Unlike antihistamine eye drops that block histamine receptors, sodium cromoglicate stabilises mast cells, preventing the release of multiple inflammatory mediators. This broader mechanism can be advantageous in chronic or severe allergic eye disease, while antihistamines may provide faster relief of itching but do not address underlying mast‑cell activation.

Store the eye‑drop solution at room temperature, ideally below 25 °C, in its original packaging. Protect it from direct sunlight, moisture and extreme temperature fluctuations. Keep the container tightly closed when not in use and discard any product that appears discoloured or contaminated.

The product is applied as an ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and instil the prescribed number of drops into the conjunctival sac. Close the eyes gently for a few seconds and avoid blinking excessively to allow proper absorption.

Serious adverse events, although rare, include severe allergic reactions such as angioedema or anaphylaxis, ocular infections, corneal ulceration and sudden vision loss. Any of these symptoms require immediate medical evaluation and discontinuation of the product.

Patients with a known hypersensitivity to sodium cromoglicate or any excipients in the formulation should avoid using the product. It is also contraindicated in individuals who have experienced severe ocular reactions to mast‑cell stabilisers and in those for whom the prescriber determines the risk outweighs the benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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