Product image of Natriumoksybat Kalceks (Sodium Oxybate) supplied by GNH India

Natriumoksybat Kalceks

Active Ingredient:
Sodium Oxybate
Origin:
EU

Natriumoksybat Kalceks (Sodium Oxybate)

Sodium oxybate, the active ingredient in Natriumoksybat Kalceks, is a gamma‑hydroxybutyrate (GHB) analog presented as an oral formulation for oral use. It is indicated for the treatment of narcolepsy with cataplexy in adult patients.
GNH India supplies Natriumoksybat Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Sodium oxybate acts on the central nervous system to manage symptoms of a specific sleep disorder.

  • Narcolepsy with cataplexy: Reduces the frequency of cataplexy episodes and improves nighttime sleep quality.

How It Works

  • Sodium oxybate functions as an agonist at both GHB receptors and GABA_B receptors in the brain, leading to central nervous system depression. This activity enhances slow‑wave sleep, consolidates nocturnal sleep, and stabilizes wakefulness, thereby diminishing cataplexy and excessive daytime sleepiness associated with narcolepsy.

Side Effects

Sodium oxybate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Vomiting: occasional emesis.
  • Insomnia: difficulty initiating sleep.
  • Weight loss: reduced appetite.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort.
  • Seizures: rare convulsive episodes.
  • Severe hypotension: marked drop in blood pressure.
  • Confusion or delirium: altered mental status.
  • Abuse potential: risk of dependence with misuse.
  • Anaphylaxis: rare severe allergic reaction.

Precautions & Warnings

When prescribing sodium oxybate, several safety considerations are essential.

  • Dose titration: Initiate at the lowest effective dose and increase only under medical supervision.
  • Alcohol avoidance: Concurrent intake can cause profound CNS depression.
  • Respiratory monitoring: Observe patients with sleep‑disordered breathing.
  • Pregnancy: Use only if benefits outweigh potential risks; data are limited.
  • Renal impairment: Adjust dosing in patients with reduced kidney function.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Sodium oxybate can interact with other central nervous system depressants and certain serotonergic agents.

Major Interactions (Avoid)

  • Alcohol: additive CNS depression may be life‑threatening.
  • Opioids: combined use increases risk of respiratory depression.
  • Benzodiazepines: may cause excessive sedation and respiratory compromise.

Moderate Interactions (Monitor Closely):\n- Antidepressants (SSRIs, SNRIs): potential for serotonin syndrome; monitor symptoms.

  • Antihistamines: may enhance sedative effects; observe patient response.

Frequently Asked Questions

Natriumoksybat Kalceks contains sodium oxybate and is prescribed to treat narcolepsy with cataplexy, helping to reduce cataplexy attacks and improve nighttime sleep quality in adult patients.

Sodium oxybate acts as an agonist at GHB and GABA_B receptors in the brain, promoting deep sleep and stabilizing wakefulness, which together lessen the frequency of cataplexy episodes and daytime sleepiness.

The specific dose and dosing schedule are determined by the prescribing clinician based on individual patient needs, response, and safety considerations; patients should follow the prescriber’s instructions exactly.

Safety data in pregnancy and lactation are limited. Use is only recommended if the potential benefit justifies the potential risk to the fetus or infant, and it should be discussed with a healthcare professional.

Enquiries can be submitted on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Sodium oxybate is the only medication approved specifically for cataplexy and offers a unique mechanism by enhancing slow‑wave sleep, whereas other agents such as modafinil primarily address daytime sleepiness without directly reducing cataplexy.

Store the product at ambient temperature below 25 °C, in its original packaging, and protect it from moisture to maintain stability and potency.

The medication is taken orally, usually in divided doses at night as directed by the prescriber, to align with the patient’s sleep schedule and therapeutic goals.

Serious risks include respiratory depression, seizures, severe hypotension, confusion, and potential for abuse or dependence; patients should be monitored closely for these events.

Individuals with known hypersensitivity to sodium oxybate, severe respiratory disorders, uncontrolled sleep apnea, or those who cannot avoid alcohol or other CNS depressants should not use this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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