Product image of Natriumoxibat Reig Jofre (Sodium Oxybate) supplied by GNH India

Natriumoxibat Reig Jofre

Active Ingredient:
Sodium Oxybate
Origin:
EU

Natriumoxibat Reig Jofre (Sodium Oxybate)

Sodium oxybate, the active ingredient in Natriumoxibat Reig Jofre, is a gamma‑hydroxybutyrate (GHB) central nervous system depressant presented as an oral formulation for oral use. It is indicated for the treatment of narcolepsy with cataplexy and excessive daytime sleepiness in adult patients.
GNH India supplies Natriumoxibat Reig Jofre as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorio Reig Jofre, S.A.

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Indications & Clinical Uses

  • Sodium oxybate acts on the sleep‑wake regulation pathway and is used for specific narcolepsy‑related conditions.
  • Narcolepsy with cataplexy: reduces the frequency and severity of cataplexy episodes.
  • Excessive daytime sleepiness: improves wakefulness and reduces daytime sleepiness.
  • Narcolepsy (overall): helps normalize sleep architecture and consolidates nighttime sleep.

How It Works

  • Sodium oxybate is an agonist at GABA_B receptors in the central nervous system. By stimulating these receptors, it enhances slow‑wave sleep, stabilizes sleep architecture, and suppresses abnormal REM phenomena that underlie cataplexy and daytime sleepiness, thereby improving overall sleep quality in patients with narcolepsy.

Side Effects

Sodium oxybate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Vomiting: occasional emesis.
  • Insomnia: difficulty maintaining sleep.
  • Weight loss: reduced appetite or caloric intake.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort, especially with other depressants.
  • Seizures: rare convulsive events.
  • Severe hypotension: marked drop in blood pressure.
  • Abuse potential: risk of dependence or misuse.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Coma: profound central nervous system depression.

Precautions & Warnings

  • When prescribing sodium oxybate, clinicians should consider several safety measures.
  • Assess sleep hygiene: ensure patients follow proper sleep‑schedule practices.
  • Monitor respiratory function: watch for signs of depression, especially with other CNS depressants.
  • Avoid concomitant CNS depressants: alcohol, opioids, benzodiazepines increase risk.
  • Use with caution in hepatic impairment: liver dysfunction may alter drug clearance.
  • Pregnancy and breastfeeding: safety not established; weigh risks versus benefits.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Sodium oxybate can interact with other medicines, altering its safety profile.

Major Interactions (Avoid)

  • Alcohol: additive CNS depression.
  • Opioids: heightened risk of respiratory depression.
  • Benzodiazepines: synergistic sedative effects.
  • Barbiturates: increased central nervous system depression.
  • Other GHB‑containing products: risk of overdose.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): may affect sleep architecture.
  • Antihistamines: can enhance sedation.
  • Anticonvulsants: potential alteration of seizure threshold.
  • Antihypertensives: possible additive hypotensive effect.

Frequently Asked Questions

Natriumoxibat Reig Jofre contains sodium oxybate and is prescribed to manage narcolepsy with cataplexy and to reduce excessive daytime sleepiness in adult patients. It helps improve nighttime sleep quality and stabilizes the sleep‑wake cycle.

Sodium oxybate acts as an agonist at GABA_B receptors, enhancing slow‑wave sleep and modulating sleep architecture. This action reduces cataplexy episodes and daytime sleepiness by promoting more restorative nighttime sleep.

The dose of sodium oxybate is individualized. A qualified prescriber determines the appropriate amount and dosing schedule based on the patient’s clinical condition, response, and tolerability.

Safety data for sodium oxybate in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing individuals.

To request Natriumoxibat Reig Jofre, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Sodium oxybate is unique in targeting both cataplexy and excessive daytime sleepiness by enhancing slow‑wave sleep, whereas many other agents primarily address wakefulness (e.g., modafinil) or cataplexy alone (e.g., pitolisant). Its dual mechanism offers comprehensive symptom control but requires careful monitoring.

Store Natriumoxibat Reig Jofre at ambient temperature, below 25 °C, in the original packaging. Keep it away from moisture, direct sunlight, and sources of heat to maintain product stability.

The medication is taken orally, typically as a liquid or tablet, as directed by the prescribing clinician. It is usually administered at night, with the dose divided into two equal portions taken several hours apart.

Serious risks include respiratory depression, severe hypotension, seizures, and potential for misuse or dependence. Patients should be monitored closely for signs of these events, especially when combined with other central nervous system depressants.

Individuals with known hypersensitivity to sodium oxybate, severe hepatic impairment, or a history of substance abuse should avoid this medication. It is also contraindicated in patients who are currently consuming alcohol or other CNS depressants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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