Product image of Natriumoxibat Reig Jofre (Sodium Oxybate) supplied by GNH India

Natriumoxibat Reig Jofre

Active Ingredient:
Sodium Oxybate
Origin:
EU

Natriumoxibat Reig Jofre (Sodium Oxybate)

Sodium Oxybate, the active ingredient in Natriumoxibat Reig Jofre, is a Gamma‑hydroxybutyrate (GHB) analog presented as an oral formulation for oral use. It is indicated for the treatment of narcolepsy with cataplexy and excessive daytime sleepiness in adult patients.

GNH India supplies Natriumoxibat Reig Jofre as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Laboratorio Reig Jofre, S.A.

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Indications & Clinical Uses

Sodium Oxybate is used in the management of sleep‑wake disorders, particularly narcolepsy.

  • Narcolepsy with cataplexy: reduces the frequency and severity of cataplexy episodes.
  • Excessive daytime sleepiness: improves wakefulness and lessens daytime sleepiness.
  • Narcolepsy (overall): consolidates nighttime sleep architecture, leading to better daytime alertness.

How It Works

  • Sodium Oxybate acts as an agonist at both GHB receptors and GABA_B receptors in the central nervous system. Activation of these receptors produces neuronal inhibition, promotes slow‑wave (deep) sleep, and reduces the occurrence of cataplexy and excessive daytime sleepiness associated with narcolepsy.

Side Effects

Adverse reactions may occur with sodium oxybate therapy.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Enuresis: nighttime urinary incontinence.
  • Insomnia: difficulty initiating sleep.
  • Irritability: mood changes or agitation.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort, potentially life‑threatening.
  • Seizures: rare occurrence of convulsive episodes.
  • Severe hypotension: marked drop in blood pressure.
  • Allergic reactions: rash, swelling, or anaphylaxis.
  • Abuse potential: risk of dependence with misuse.

Precautions & Warnings

Sodium oxybate requires careful patient assessment and monitoring.

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown excretion; consider potential infant exposure.
  • Renal impairment: dose may need adjustment; monitor renal function.
  • Alcohol use: contraindicated due to additive CNS depression.
  • Driving or operating machinery: avoid until individual response is known.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Sodium oxybate can interact with several drug classes.

Major Interactions (Avoid)

  • Alcohol: additive central nervous system depression.
  • Other CNS depressants (e.g., benzodiazepines, opioids): risk of severe respiratory depression.
  • Additional GHB‑containing products: potential overdose and profound sedation.

Moderate Interactions (Monitor Closely)

  • Monoamine oxidase inhibitors (MAOIs): may amplify CNS effects.
  • Antihypertensive agents: possible enhancement of hypotensive response.
  • Anticonvulsants: may alter seizure threshold or drug levels.

Frequently Asked Questions

Natriumoxibat Reig Jofre contains sodium oxybate, which is prescribed to treat narcolepsy with cataplexy and to reduce excessive daytime sleepiness in adult patients. It helps improve nighttime sleep quality and stabilises daytime alertness.

Sodium oxybate binds to GHB receptors and GABA_B receptors in the brain, producing central nervous system depression. This action enhances slow‑wave sleep and diminishes the frequency of cataplexy episodes, thereby improving overall wakefulness.

The dosage of sodium oxybate is individualized. A qualified prescriber determines the appropriate dose and titration schedule based on the patient’s clinical response and tolerability. No generic dosing regimen is provided here.

Safety data for sodium oxybate in pregnancy and lactation are limited. It is generally advised to avoid use during pregnancy unless the potential benefit justifies the risk, and breastfeeding is not recommended without careful risk assessment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Sodium oxybate is unique in that it directly enhances slow‑wave sleep, whereas most other narcolepsy drugs (e.g., modafinil, armodafinil) act as wake‑promoting agents. Sodium oxybate is the only medication approved specifically for cataplexy, offering a distinct therapeutic option.

Store the product at ambient temperature below 25 °C, in its original packaging, and protect it from moisture. Do not expose it to extreme heat or direct sunlight to maintain product stability.

The medication is taken orally, usually in divided doses at night as directed by the prescribing clinician. It is important to follow the exact timing and dosing instructions to achieve optimal therapeutic effect.

The most serious risks include respiratory depression, severe hypotension, seizures, and potential for misuse or dependence. Patients should be monitored closely for any signs of these adverse events, especially during treatment initiation.

Sodium oxybate is contraindicated in patients with known hypersensitivity to the drug, those who consume alcohol or other CNS depressants, individuals with severe respiratory disorders, and patients with a history of substance abuse unless closely supervised.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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