Product image of Natriumoxybaat Kalceks (Sodium Oxybate) supplied by GNH India

Natriumoxybaat Kalceks

Active Ingredient:
Sodium Oxybate
Origin:
EU

Natriumoxybaat Kalceks (Sodium Oxybate)

Sodium Oxybate, the active ingredient in Natriumoxybaat Kalceks, is a GABA_B receptor agonist presented as an oral formulation for oral use. It is indicated for the treatment of narcolepsy with cataplexy, helping to improve nighttime sleep continuity and reduce daytime cataplexy episodes.

GNH India supplies Natriumoxybaat Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides full regulatory documentation and reliable support to facilitate import and distribution.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Sodium Oxybate acts on the central nervous system to treat disorders of sleep regulation, particularly narcolepsy with cataplexy.

  • Narcolepsy with cataplexy: improves nighttime sleep continuity and reduces cataplexy episodes.
  • Cataplexy attacks (narcolepsy subtype): decreases frequency and severity of sudden muscle weakness.
  • Excessive daytime sleepiness (narcolepsy): enhances daytime alertness and functional performance.

How It Works

  • Sodium Oxybate binds to and activates GABA_B receptors in the central nervous system, enhancing inhibitory neurotransmission. This modulation of GABAergic pathways leads to alterations in sleep architecture, promoting deeper slow‑wave sleep and reducing the occurrence of cataplexy by stabilizing neuronal excitability.

Side Effects

Sodium Oxybate may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Insomnia: difficulty initiating sleep.
  • Weight loss: reduced appetite or caloric intake.
  • Anxiety: feelings of nervousness or tension.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort, especially with concurrent depressants.
  • Seizures: rare occurrence of convulsive episodes.
  • Hallucinations or psychosis: altered perception or mental status.
  • Severe hypotension: marked drop in blood pressure.
  • Allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Sodium Oxybate, clinicians should consider several safety measures.

  • Monitor respiratory function: patients with sleep‑disordered breathing may experience worsening.
  • Avoid alcohol: concurrent use can cause additive central nervous system depression.
  • Assess renal function: impaired clearance may require dose adjustment.
  • Use caution in depression: increased risk of suicidal ideation has been reported.
  • Pregnancy: limited data; use only if the potential benefit justifies the potential risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Sodium Oxybate can interact with other medications, necessitating careful review.

Major Interactions (Avoid)

  • Alcohol: additive CNS depression leading to severe sedation.
  • Opioids: heightened risk of respiratory depression and overdose.
  • Benzodiazepines: enhanced sedative effects and possible respiratory compromise.

Moderate Interactions (Monitor Closely):\n- Antidepressants (SSRIs, SNRIs): may increase risk of serotonin syndrome.

  • Antihypertensives: potential potentiation of hypotensive effects.
  • CYP2C19 inhibitors: may raise plasma concentrations of Sodium Oxybate.

Frequently Asked Questions

Natriumoxybaat Kalceks contains Sodium Oxybate, which is prescribed to treat narcolepsy with cataplexy. It helps normalize nighttime sleep patterns and reduces the frequency of sudden muscle weakness episodes that occur during the day.

Sodium Oxybate acts as an agonist at GABA_B receptors, enhancing inhibitory signaling in the central nervous system. This action modifies sleep architecture, increasing deep sleep and stabilizing neuronal activity, which together lessen cataplexy and improve daytime alertness.

The dosage of Sodium Oxybate is individualized. A qualified prescriber determines the appropriate dose and dosing schedule based on the patient’s clinical condition, response, and safety considerations.

Safety data for Sodium Oxybate in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Sodium Oxybate is unique in that it directly improves nocturnal sleep quality and specifically reduces cataplexy, whereas other agents such as modafinil primarily promote wakefulness. The choice of therapy depends on the patient’s symptom profile, comorbidities and physician assessment.

Store the product at ambient temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight and sources of heat to maintain stability.

Sodium Oxybate is taken orally, usually as a liquid solution, in divided doses at night as directed by the prescribing clinician. The exact administration schedule should follow the physician’s instructions.

The most serious risks include respiratory depression, seizures, severe hypotension, and rare psychiatric effects such as hallucinations. Patients should be monitored closely, especially when other central nervous system depressants are used.

Sodium Oxybate is contraindicated in patients with known hypersensitivity to the drug, severe respiratory disorders, uncontrolled depression, or those who consume alcohol or other CNS depressants. It should also be avoided in individuals for whom the risks outweigh the therapeutic benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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