Product image of Natriumpolystyreensulfonaat Focus (Sodium Polystyrene Sulfonate) supplied by GNH India

Natriumpolystyreensulfonaat Focus

Active Ingredient:
Sodium Polystyrene Sulfonate
Origin:
EU

Natriumpolystyreensulfonaat Focus (Sodium Polystyrene Sulfonate)

Sodium Polystyrene Sulfonate, the active ingredient in Natriumpolystyreensulfonaat Focus, is an ion‑exchange resin presented as a powder for oral and rectal use. It binds potassium in the gastrointestinal tract and is used to lower elevated serum potassium levels in patients with hyperkalemia.
GNH India supplies Natriumpolystyreensulfonaat Focus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Focus Care Pharmaceuticals B.V.

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Indications & Clinical Uses

Sodium Polystyrene Sulfonate acts as a potassium‑binding ion‑exchange resin to treat conditions associated with excess potassium.

  • Hyperkalemia: reduces serum potassium concentrations in acute settings.
  • Chronic hyperkalemia: helps maintain long‑term potassium balance in patients with renal impairment.
  • Pre‑dialysis preparation: lowers potassium levels before dialysis sessions.

How It Works

  • Sodium Polystyrene Sulfonate is an insoluble polymer that exchanges its sodium ions for potassium ions within the gastrointestinal lumen. The resin binds potassium, forming a non‑absorbable complex that is eliminated in the feces, thereby decreasing the amount of potassium reabsorbed into the bloodstream and lowering serum potassium levels.

Side Effects

Sodium Polystyrene Sulfonate may cause gastrointestinal and electrolyte disturbances.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional expulsion of stomach contents.
  • Constipation: reduced bowel movements.
  • Diarrhea: loose stools.
  • Abdominal discomfort: cramping or pain.
  • Taste alteration: metallic or salty taste.

Serious or Rare Side Effects

  • Intestinal necrosis: severe bowel tissue damage.
  • Bowel obstruction: blockage requiring medical attention.
  • Severe electrolyte imbalance: marked hypokalemia or hypernatremia.
  • Allergic reactions: rash, itching, or swelling.
  • Hypovolemia: significant fluid loss.
  • Metabolic acidosis: abnormal blood pH.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient-specific risk factors and monitor therapy closely.

  • Baseline assessment: obtain serum potassium and electrolytes prior to start.
  • Ongoing monitoring: check potassium and sodium levels regularly during treatment.
  • Renal impairment: adjust use in patients with reduced kidney function.
  • Gastrointestinal disorders: use cautiously in patients with bowel disease or recent surgery.
  • Concomitant sorbitol: avoid sorbitol‑containing laxatives due to necrosis risk.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Sodium Polystyrene Sulfonate can affect the absorption and activity of several drugs.

Major Interactions (Avoid)

  • Sorbitol‑containing laxatives: increase risk of intestinal necrosis.
  • ACE inhibitors: additive potassium‑raising effect.
  • Potassium‑sparing diuretics: may exacerbate hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Digoxin: serum potassium changes can alter digoxin toxicity.
  • Insulin therapy: monitor for hypokalemia when insulin is used concurrently.

Frequently Asked Questions

Natriumpolystyreensulfonaat Focus contains sodium polystyrene sulfonate, an ion‑exchange resin that binds potassium in the gastrointestinal tract. It is prescribed to lower elevated serum potassium levels in patients with hyperkalemia, including acute and chronic cases.

The resin exchanges its sodium ions for potassium ions in the gut. The bound potassium forms a non‑absorbable complex that is eliminated with feces, reducing the amount of potassium reabsorbed into the bloodstream and thereby lowering serum potassium concentrations.

The dose of sodium polystyrene sulfonate is individualized by the prescribing clinician based on the patient’s serum potassium level, renal function, and overall clinical condition. No fixed dosing regimen is provided here.

The safety of sodium polystyrene sulfonate in pregnancy and lactation has not been definitively established. Clinicians should weigh potential benefits against possible risks and consider alternative therapies when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Sodium polystyrene sulfonate is a well‑established ion‑exchange resin, whereas newer agents such as patiromer and sodium zirconium cyclosilicate have different mechanisms and may have distinct safety profiles. Choice of therapy depends on patient tolerance, renal function, and clinician preference.

Store the product at ambient temperature, below 25 °C, in its original packaging. Protect it from moisture and direct sunlight to maintain stability.

The resin is supplied as a powder that can be mixed with water or other suitable liquid for oral administration, or it may be administered rectally as a suspension, depending on the formulation prescribed by the healthcare professional.

Serious risks include intestinal necrosis, severe electrolyte disturbances such as hypokalemia or hypernatremia, and bowel obstruction. Prompt medical attention is required if patients experience severe abdominal pain, vomiting blood, or signs of electrolyte imbalance.

Patients with known hypersensitivity to sodium polystyrene sulfonate, those with active gastrointestinal obstruction, recent bowel surgery, or severe constipation should avoid this product. Clinicians should also exercise caution in patients receiving sorbitol‑containing laxatives.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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