Natriumtiosulfat Hope (Sodium Thiosulfate)

Sodium thiosulfate provides a sulfur donor that enhances the mitochondrial enzyme rhodanese, converting toxic cyanide into the far less harmful thiocyanate, which is then eliminated in the urine. It also binds calcium ions, helping to reduce calcium deposition in tissues.

The dosage of sodium thiosulfate is determined by the prescribing clinician based on the specific indication, severity of poisoning, patient weight, renal function, and other clinical factors. No fixed regimen is provided here.

Safety data for sodium thiosulfate in pregnancy and lactation are limited. It should only be used when the potential therapeutic benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Natriumtiosulfat Hope, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and necessary import documentation.

The primary alternative cyanide antidote is hydroxocobalamin, which directly binds cyanide to form cyanocobalamin. Sodium thiosulfate works indirectly by enhancing enzymatic conversion to thiocyanate. Hydroxocobalamin provides rapid detoxification but may cause discoloration of bodily fluids, whereas sodium thiosulfate is often preferred when calcium chelation is also needed, such as in calciphylaxis.

The product must be stored refrigerated between 2 °C and 8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability and sterility.

Natriumtiosulfat Hope is administered intravenously by a qualified healthcare professional. The solution is typically diluted in compatible IV fluids and infused over a controlled period, with vital signs monitored throughout the administration.

Serious adverse reactions include anaphylaxis, severe hypotension, metabolic acidosis, and acute renal impairment. Immediate medical attention is required if any of these events occur during or after infusion.

Sodium thiosulfate should be avoided in patients with known hypersensitivity to the product, severe renal impairment where clearance is compromised, and in individuals where the risk of significant calcium chelation outweighs therapeutic benefit.