Product image of Natriumwaterstofcarbonaat (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumwaterstofcarbonaat

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumwaterstofcarbonaat (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumwaterstofcarbonaat, is an excipient presented as an intravenous solution for intravenous use. It provides bicarbonate ions that act as a buffering agent to correct metabolic acidosis and maintain acid‑base balance when administered intravenously.

GNH India supplies Natriumwaterstofcarbonaat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Nederland B.V.

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Indications & Clinical Uses

Natriumwaterstofcarbonaat acts as a buffering agent in conditions where acid‑base balance is disturbed.

  • Metabolic acidosis: corrects low blood pH by supplying bicarbonate ions.
  • Renal replacement therapy: helps maintain systemic pH during dialysis.
  • Cardiopulmonary bypass surgery: supports acid‑base homeostasis during the procedure.

How It Works

  • Sodium hydrogen carbonate dissociates in plasma to release bicarbonate ions, which combine with hydrogen ions to form carbonic acid. This reaction raises extracellular pH, shifting the acid‑base equilibrium toward neutrality and thereby correcting metabolic acidosis when administered intravenously.

Side Effects

Adverse reactions may occur with intravenous sodium hydrogen carbonate administration.

Common Side Effects

  • Hypernatremia: elevated serum sodium levels.
  • Metabolic alkalosis: excessive increase in blood pH.
  • Fluid overload: volume expansion leading to edema.
  • Hypokalemia: reduced serum potassium.
  • Local IV site irritation: pain or phlebitis at infusion site.
  • Transient rise in arterial CO₂: due to rapid bicarbonate conversion.

Serious or Rare Side Effects

  • Severe metabolic alkalosis: can cause respiratory depression.
  • Cardiac arrhythmias: secondary to electrolyte disturbances.
  • Pulmonary edema: from fluid overload.
  • Severe hypernatremia: neurologic impairment.
  • Anaphylactic reaction: rare hypersensitivity.
  • Life‑threatening electrolyte imbalance: requiring urgent correction.

Precautions & Warnings

When using Natriumwaterstofcarbonaat, clinicians should observe several safety measures.

  • Renal impairment: monitor serum electrolytes and fluid status.
  • Cardiac disease: watch for signs of fluid overload and arrhythmias.
  • Respiratory compromise: avoid rapid infusion that may increase CO₂ retention.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Concomitant alkalinizing agents: avoid overcorrection of pH.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Sodium hydrogen carbonate may interact with other medications affecting acid‑base balance or electrolyte status.

Major Interactions (Avoid)

  • Concurrent use with other alkalinizing agents (e.g., sodium citrate) – risk of severe alkalosis.
  • Combination with loop diuretics – may exacerbate metabolic alkalosis.

Moderate Interactions (Monitor Closely)

  • Co‑administration with potassium‑sparing diuretics – monitor potassium levels.
  • Use with antacids – may alter gastric pH and affect drug absorption.
  • Concurrent insulin therapy – monitor for shifts in potassium.
  • Certain antibiotics (e.g., penicillins) – may affect urinary excretion; monitor renal function.

Frequently Asked Questions

Natriumwaterstofcarbonaat is an intravenous sodium bicarbonate solution used as a buffering agent to correct metabolic acidosis and to maintain acid‑base balance during procedures such as dialysis or cardiopulmonary bypass.

When administered intravenously, sodium hydrogen carbonate dissociates into sodium and bicarbonate ions. The bicarbonate combines with excess hydrogen ions to form carbonic acid, which is then converted to CO₂ and water, raising blood pH and restoring normal acid‑base equilibrium.

The appropriate dose is determined by the prescribing clinician based on the patient’s clinical condition, serum electrolyte levels, and the degree of acidosis. Dosage is individualized and should follow the prescriber’s instructions.

Safety data for use in pregnancy or lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Sodium hydrogen carbonate is the most widely used intravenous buffer because it directly supplies bicarbonate ions, offering rapid correction of acidosis. Alternative buffers such as tromethamine or acetate may be used in specific settings, but they have different metabolic pathways and electrolyte effects.

Store the solution at ambient temperature, preferably below 25 °C, in its original sealed container. Protect it from direct sunlight, moisture, and extreme temperature fluctuations to maintain stability.

The product is given by intravenous infusion. Administration rate and concentration are determined by the prescriber, often using a controlled infusion pump to ensure accurate delivery and to monitor patient response.

Serious risks include severe metabolic alkalosis, hypernatremia, cardiac arrhythmias, pulmonary edema, and rare anaphylactic reactions. Continuous monitoring of blood gases, electrolytes and fluid status is essential during therapy.

Patients with known hypersensitivity to sodium bicarbonate, uncontrolled severe hypertension, or those at high risk for fluid overload and severe electrolyte disturbances should avoid this product unless a careful risk‑benefit assessment justifies its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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