Product image of Natriumwaterstofcarbonaat B.Braun Melsungen (Sodium Hydrogen Carbonate) supplied by GNH India

Natriumwaterstofcarbonaat B.Braun Melsungen

Active Ingredient:
Sodium Hydrogen Carbonate
Origin:
EU

Natriumwaterstofcarbonaat B.Braun Melsungen (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumwaterstofcarbonaat B.Braun Melsungen, is an alkali/buffering agent presented as a sterile solution for injection for intravenous use. It is employed to correct metabolic acidosis, support advanced cardiac life support, facilitate intracellular potassium shift in hyperkalemia, and alkalinise acidic urine in clinical practice.

GNH India supplies Natriumwaterstofcarbonaat B.Braun Melsungen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides reliable logistics for global healthcare providers.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Sodium hydrogen carbonate is used to manage disorders of acid‑base balance and related emergency conditions.
  • Metabolic acidosis: restores systemic pH by providing bicarbonate ions.
  • Cardiac arrest (advanced cardiac life support): buffers acidosis during resuscitation.
  • Hyperkalemia: promotes intracellular shift of potassium, helping lower serum potassium levels.
  • Acidic urine alkalinisation: raises urinary pH to facilitate certain drug excretion.

How It Works

  • Sodium hydrogen carbonate dissociates in plasma to release bicarbonate ions, which combine with hydrogen ions to form carbonic acid that is rapidly converted to CO₂ and water. This buffering reaction increases blood bicarbonate concentration, elevating systemic pH and counteracting metabolic acidosis, while also driving potassium into cells via the Na⁺/K⁺‑ATPase, aiding correction of hyperkalemia.

Side Effects

Common Side Effects

  • Injection site discomfort: mild pain or erythema at the infusion site.
  • Hypernatremia: elevated serum sodium from the sodium load.
  • Metabolic alkalosis: excessive rise in blood pH.
  • Fluid overload: increased intravascular volume, especially in patients with cardiac failure.

Serious or Rare Side Effects

  • Severe metabolic alkalosis: can cause seizures or respiratory depression.
  • Pulmonary edema: due to rapid volume expansion.
  • Anaphylactic reaction: rare hypersensitivity with hypotension and airway compromise.

Precautions & Warnings

Precautions should be taken when using sodium hydrogen carbonate injection.

  • Assess renal function: impaired kidneys may reduce bicarbonate excretion.
  • Evaluate cardiac status: patients with heart failure risk fluid overload.
  • Monitor electrolytes: frequent checks of sodium, potassium, and calcium are recommended.
  • Adjust dose in severe metabolic alkalosis: avoid over‑correction.
  • Avoid in untreated hypocalcemia: may exacerbate calcium loss.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sodium hydrogen carbonate may interact with several medicines.

Major Interactions (Avoid)

  • Sodium bicarbonate + calcium channel blockers: may reduce blocker efficacy.
  • Sodium bicarbonate + thiazide diuretics: risk of severe metabolic alkalosis.
  • Sodium bicarbonate + potassium‑sparing diuretics: may cause hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Sodium bicarbonate + aminoglycoside antibiotics: increased nephrotoxicity risk.
  • Sodium bicarbonate + NSAIDs: may impair renal bicarbonate excretion.
  • Sodium bicarbonate + antacids: additive alkalinising effect.

Frequently Asked Questions

Natriumwaterstofcarbonaat is an injectable sodium bicarbonate solution used in hospital settings to correct metabolic acidosis, support advanced cardiac life support, treat hyperkalemia, and alkalinise acidic urine.

The compound dissociates into bicarbonate ions that combine with hydrogen ions, forming carbonic acid that is rapidly converted to CO₂ and water. This buffering raises systemic pH and also promotes intracellular potassium shift, helping to lower serum potassium levels.

The dose is determined by the prescribing clinician based on the patient’s acid‑base status, serum electrolytes and clinical condition. Dosing regimens are individualized and are not standardized in the product description.

Safety data are limited and the product is classified as pregnancy category unknown. It should be used only if the potential benefit justifies any potential risk to the mother or infant, and under close medical supervision.

Submit an enquiry on the product page at gnhindia.com, providing the required quantity and institutional credentials. GNH India will verify eligibility, then respond with pricing, availability, shipping details and any required import documentation.

Sodium hydrogen carbonate is the standard inorganic buffer offering rapid correction of acidosis with a well‑known safety profile. Compared with organic buffers such as tromethamine, it provides faster pH normalization but adds a sodium load, which may be a consideration in volume‑restricted patients.

The solution should be stored at 2‑8 °C, kept in the original container, protected from light, and must not be frozen or shaken to maintain stability.

It is given intravenously, typically as an infusion diluted in compatible IV fluids. The administration rate is set by the clinician according to the severity of acidosis and the patient’s tolerance.

Serious adverse events include severe metabolic alkalosis, pulmonary edema from rapid volume expansion, and rare anaphylactic reactions. Patients should be closely monitored for electrolyte disturbances, respiratory status and signs of fluid overload.

Contra‑indications include untreated hypocalcemia, severe uncompensated metabolic alkalosis, and patients with uncontrolled fluid overload or severe renal impairment where bicarbonate excretion is limited.

Published by

GNH India Pharmaceuticals Limited

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Last updated:

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