Product image of Natterman Bronchicum Extra Sterk (Codeine Phosphate Hemihydrate) supplied by GNH India

Natterman Bronchicum Extra Sterk

Active Ingredient:
Codeine Phosphate Hemihydrate
Origin:
EU

Natterman Bronchicum Extra Sterk (Codeine Phosphate Hemihydrate)

Codeine phosphate, the active ingredient in Natterman Bronchicum Extra Sterk, is an opioid analgesic presented as an oral formulation for oral use. It suppresses cough and may provide mild analgesia in appropriate patients.
GNH India supplies Natterman Bronchicum Extra Sterk as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vemedia Manufacturing B. V.

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Indications & Clinical Uses

Codeine phosphate acts on the central cough centre and provides opioid analgesia, making it useful for conditions where cough suppression or mild pain relief is needed.

  • Cough: reduces the frequency and intensity of acute or chronic cough.
  • Mild to moderate pain: offers short‑term opioid analgesia for transient pain.
  • Cough associated with respiratory infections: alleviates coughing that accompanies viral or bacterial airway infections.

How It Works

  • Codeine phosphate is a mu‑opioid receptor agonist. After oral absorption, it crosses the blood‑brain barrier and binds to µ‑receptors in the medullary cough centre, raising the threshold for cough reflex activation. The same receptor interaction also produces mild analgesic effects by modulating pain pathways in the central nervous system.

Side Effects

Codeine phosphate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: feeling of sickness or urge to vomit.
  • Constipation: reduced bowel movements and hard stools.
  • Drowsiness: increased sleepiness or reduced alertness.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Vomiting: expulsion of stomach contents.
  • Dry mouth: reduced salivation leading to a parched feeling.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing that can be life‑threatening.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Seizures: convulsive episodes, especially at high doses.
  • Hypotension: abnormally low blood pressure.
  • Dependence or addiction: potential for misuse with prolonged use.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before prescribing Natterman Bronchicum Extra Sterk, clinicians should consider several safety factors.

  • Pregnancy: safety is unknown; use only if the benefit outweighs the risk.
  • Breastfeeding: unknown safety; assess potential infant exposure.
  • Renal or hepatic impairment: dose may need adjustment and monitoring.
  • Concomitant CNS depressants: increased risk of sedation and respiratory depression.
  • History of substance abuse: avoid due to dependence potential.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Codeine phosphate can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other opioid analgesics: additive risk of respiratory depression.
  • Benzodiazepines: enhanced sedation and respiratory depression.
  • Alcohol: increased central nervous system depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine): may raise codeine plasma levels.
  • CYP3A4 inducers (e.g., rifampicin): may reduce codeine effectiveness.
  • Anticholinergics: may exacerbate constipation.

Frequently Asked Questions

Natterman Bronchicum Extra Sterk is a prescription medication containing codeine phosphate, primarily used as a cough suppressant to reduce the frequency and intensity of coughing in patients with acute or chronic cough, and it may also provide short‑term relief of mild to moderate pain when indicated.

Codeine phosphate is a mu‑opioid receptor agonist. By binding to µ‑receptors in the central nervous system, especially in the medullary cough centre, it raises the threshold for cough reflex activation, thereby suppressing cough. It also exerts mild analgesic effects through the same receptor pathway.

The specific dose of Natterman Bronchicum Extra Sterk is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and local regulatory guidelines. Patients should follow the prescriber’s instructions and the product label; dosing should not be altered without medical advice.

Safety data for codeine phosphate during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑opioid antitussives such as dextromethorphan, codeine phosphate provides a stronger central cough‑suppressing effect due to its µ‑opioid receptor activity, but it also carries a higher risk of opioid‑related adverse effects and dependence. Selection depends on the severity of cough, patient risk factors and clinical judgment.

Natterman Bronchicum Extra Sterk should be stored below 25 °C in a dry place, protected from moisture and direct sunlight. Keep the product in its original packaging until use, and ensure that it is out of reach of children. Do not store in bathrooms or near heat sources.

The product is intended for oral administration. Patients should swallow the tablet whole with a glass of water, unless the prescribing information advises otherwise. It is usually taken as needed for cough relief, but the exact frequency and timing should follow the prescriber’s directions to avoid excessive dosing.

The most serious risks associated with codeine phosphate include respiratory depression, especially when combined with other central nervous system depressants, severe allergic reactions such as anaphylaxis, and the potential for dependence or abuse. Patients should seek immediate medical attention if they experience difficulty breathing, swelling of the face or throat, or uncontrolled cravings.

Natterman Bronchicum Extra Sterk should be avoided in individuals with known hypersensitivity to codeine or any component of the formulation, in patients with severe respiratory insufficiency, in those with acute or severe asthma, and in persons with a history of opioid dependence or abuse. Caution is also advised for children, the elderly, and patients with significant hepatic or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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