Product image of Natterman Noscasan (Noscapine Hydrochloride) supplied by GNH India

Natterman Noscasan

Active Ingredient:
Noscapine Hydrochloride
Origin:
EU

Natterman Noscasan (Noscapine Hydrochloride)

Noscapine Hydrochloride, the active ingredient in Natterman Noscasan, is an antitussive presented as an oral formulation for oral use. It suppresses cough by acting on the central cough reflex and is indicated for patients experiencing dry, non‑productive cough.

GNH India supplies Natterman Noscasan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vemedia Manufacturing B. V.

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Indications & Clinical Uses

Noscapine Hydrochloride is an antitussive that acts on the central cough reflex pathway to reduce coughing.

  • Acute cough: provides relief from sudden onset dry cough.
  • Chronic cough: helps decrease frequency of persistent non‑productive cough.
  • Cough associated with upper respiratory infections: eases irritation‑driven cough.

How It Works

  • Noscapine Hydrochloride exerts a central antitussive effect by binding to neuronal sites in the medullary cough center, thereby diminishing the transmission of afferent cough signals. This modulation reduces the cough reflex without significant impact on respiratory drive or bronchial tone.

Side Effects

Noscapine Hydrochloride may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset.
  • Dizziness: transient light‑headedness.
  • Drowsiness: increased sleepiness.
  • Headache: mild to moderate pain.
  • Gastrointestinal discomfort: abdominal cramping or loose stools.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Hematologic abnormalities: rare cases of neutropenia or thrombocytopenia.

Precautions & Warnings

When prescribing or dispensing Noscapine Hydrochloride, consider the following precautions.

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor hepatic health: avoid in patients with active liver disease.
  • Caution with CNS depressants: may enhance drowsiness.
  • Avoid in known hypersensitivity: discontinue if allergic signs appear.
  • Use during pregnancy only if clearly needed: limited safety data.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Noscapine Hydrochloride can interact with other medicines; be aware of the following.

Major Interactions (Avoid)

  • Other antitussives: combined use may cause excessive suppression of cough.
  • Strong CNS depressants (e.g., benzodiazepines): increased sedation risk.
  • MAO inhibitors: potential for heightened central effects.

Moderate Interactions (Monitor Closely)

  • Alcohol: may intensify drowsiness.
  • Antihistamines: additive sedation.
  • Opioid analgesics: possible enhanced respiratory depression.

Frequently Asked Questions

Natterman Noscasan contains noscapine hydrochloride, an antitussive indicated for the symptomatic relief of dry, non‑productive coughs. It is used in adults and children when a cough is irritating but not productive, helping to reduce the frequency and intensity of coughing episodes.

Noscapine hydrochloride acts centrally on the medullary cough centre. By binding to neuronal sites that modulate cough signalling, it dampens the transmission of afferent impulses that trigger the cough reflex, thereby providing cough suppression without significant bronchodilation or sedation.

The specific dose of Natterman Noscasan is determined by the prescribing clinician based on the patient’s age, weight, severity of cough, and overall health status. Healthcare professionals follow local prescribing guidelines and adjust the regimen as needed for optimal symptom control.

Safety data for noscapine hydrochloride during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider after careful assessment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with opioid‑based antitussives such as codeine, noscapine offers cough relief without the typical opioid‑related risks of dependence, respiratory depression, or significant constipation. Its central mechanism provides effective suppression of dry cough while maintaining a more favourable safety profile for many patients.

Natterman Noscasan should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain stability.

The medication is taken orally, usually as a tablet or liquid formulation, as directed by the prescribing clinician. It should be swallowed with water and taken at the intervals prescribed, without crushing or chewing unless the specific dosage form advises otherwise.

Serious adverse events, although rare, include allergic reactions such as rash, swelling or breathing difficulty, hepatic dysfunction manifested by elevated liver enzymes or jaundice, and hematologic abnormalities like neutropenia. Patients should seek immediate medical attention if any of these symptoms develop.

Individuals with known hypersensitivity to noscapine or any excipients in the product should avoid it. It is also contraindicated in patients with severe hepatic impairment and should be used with caution in those taking other central nervous system depressants. Pediatric use should follow local regulatory guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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