Product image of Natussic (Butamirate Citrate) supplied by GNH India

Natussic

Active Ingredient:
Butamirate Citrate
Origin:
EU

Natussic (Butamirate Citrate)

Butamirate citrate, the active ingredient in Natussic, is a antitussive presented as an oral dosage form for oral use. It suppresses the cough reflex and is used to relieve dry or non‑productive coughs in adults and children.
GNH India supplies Natussic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hasco-Lek

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Indications & Clinical Uses

Butamirate citrate is an antitussive that acts on the central cough reflex to reduce coughing.

  • Acute dry cough: reduces the frequency and intensity of coughing episodes.
  • Non‑productive cough: alleviates throat irritation and suppresses unwanted cough.
  • Cough associated with the common cold: provides symptomatic relief of coughing without affecting mucus clearance.

How It Works

  • Butamirate citrate suppresses the cough reflex by acting on the medullary cough centre in the brainstem. It modulates neuronal activity in this region, decreasing the sensitivity of the cough trigger pathways and thereby reducing the urge to cough without exerting significant peripheral effects.

Side Effects

Butamirate citrate is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Drowsiness: mild to moderate sleepiness.
  • Dry mouth: reduced salivation causing a dry sensation.
  • Nausea: occasional upset stomach.
  • Dizziness: transient light‑headedness.
  • Headache: mild cranial discomfort.
  • Gastrointestinal discomfort: mild abdominal pain or discomfort.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, or swelling.
  • Angioedema: swelling of the face, lips, or tongue.
  • Severe dizziness or fainting.
  • Respiratory depression (very rare).
  • Hepatic dysfunction: abnormal liver enzyme levels.
  • Anaphylaxis: rapid onset of severe allergic response.

Precautions & Warnings

Before using Natussic, consider the following safety measures.

  • Hypersensitivity assessment: avoid if the patient has known allergy to butamirate citrate.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Pediatric use: not recommended for children under 2 years of age.
  • Concomitant CNS depressants: avoid combining with other central cough suppressants or sedatives.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Butamirate citrate may interact with other medicines; monitor the following.

Major Interactions (Avoid)

  • Other central antitussives (e.g., codeine): risk of excessive sedation and respiratory depression.
  • CNS depressants (e.g., benzodiazepines, barbiturates): may potentiate drowsiness and impair coordination.

Moderate Interactions (Monitor Closely)

  • Alcohol: can increase drowsiness and dizziness.
  • Antihistamines: may enhance sedative effects.
  • Monoamine oxidase inhibitors (MAOIs): potential for heightened central nervous system effects.

Frequently Asked Questions

Natussic contains butamirate citrate, an antitussive that is used to relieve dry, non‑productive coughs and coughs associated with the common cold. It works by suppressing the cough reflex in the brain, providing symptomatic relief without affecting mucus clearance.

Butamirate citrate acts on the medullary cough centre in the brainstem, reducing the sensitivity of the neuronal pathways that trigger coughing. By modulating this central reflex, it decreases the urge to cough while having minimal peripheral activity.

The appropriate dose of Natussic is determined by a qualified healthcare professional based on the patient’s age, weight, and clinical condition. Prescribers set the dosing regimen according to local guidelines and the product’s labeling.

Safety data for butamirate citrate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Natussic to weigh potential risks and benefits.

To order Natussic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Natussic (butamirate citrate) is a non‑opioid antitussive that works centrally, similar to dextromethorphan but with a different receptor profile. Unlike codeine, it does not have opioid‑related side effects, making it a suitable OTC option for many patients requiring cough relief.

Natussic should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and efficacy throughout its shelf life.

Natussic is taken orally as directed by a healthcare professional. The tablet (or oral formulation) should be swallowed with a glass of water, and it can be taken with or without food unless otherwise advised by the prescriber.

Serious but rare risks include allergic reactions such as rash, swelling, or anaphylaxis, as well as severe dizziness or respiratory depression when combined with other central depressants. Patients should seek immediate medical attention if they experience any of these symptoms.

Natussic should not be used by individuals with known hypersensitivity to butamirate citrate, children under 2 years of age, or patients taking other central cough suppressants or strong CNS depressants without medical supervision. Consultation with a healthcare provider is essential for anyone with significant liver disease or other serious medical conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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