Product image of Nausicalm (Dimenhydrinate) supplied by GNH India

Nausicalm

Active Ingredient:
Dimenhydrinate
Origin:
EU

Nausicalm (Dimenhydrinate)

Dimenhydrinate, the active ingredient in Nausicalm, is a first‑generation antihistamine presented as an oral tablet for oral use. It treats motion‑sickness, nausea and vertigo in adults and children.

GNH India supplies Nausicalm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Les Laboratoires Brothier Sas

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Indications & Clinical Uses

Dimenhydrinate acts as an antihistamine and anticholinergic to control vestibular and gastrointestinal disturbances.

  • Motion sickness: reduces nausea, vomiting and dizziness caused by travel or movement.
  • Vertigo: alleviates dizziness associated with vestibular disorders.
  • Prevention of nausea and vomiting: used prophylactically to lessen postoperative or other acute nausea episodes.

How It Works

  • Dimenhydrinate blocks histamine H1 receptors and exhibits anticholinergic activity, which dampens vestibular stimulation and reduces the central perception of nausea. By antagonizing H1 and muscarinic receptors in the vestibular nuclei and the chemoreceptor trigger zone, it decreases the signaling pathways that lead to vomiting and vertigo.

Side Effects

Dimenhydrinate may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Blurred vision
  • Constipation
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Allergic reactions such as rash, angioedema, or anaphylaxis
  • Tachycardia or irregular heart rhythm
  • Confusion or mental status changes
  • Urinary retention, especially in patients with prostate enlargement
  • Severe hypotension
  • Rare seizures or convulsions

Precautions & Warnings

When using Dimenhydrinate, consider the following safety measures.

  • Pediatric use: follow age‑appropriate dosing guidance and monitor for excessive sedation.
  • Alcohol and CNS depressants: avoid concomitant use as it may enhance drowsiness.
  • Glaucoma: use with caution due to anticholinergic effects that can increase intra‑ocular pressure.
  • Elderly patients: monitor closely for anticholinergic burden and falls.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Dimenhydrinate can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Alcohol and other central nervous system depressants
  • Opioid analgesics
  • Benzodiazepines
  • Strong anticholinergic agents
  • Other first‑generation antihistamines

Moderate Interactions (Monitor Closely):\n- Tricyclic antidepressants

  • Antipsychotic medications
  • Diuretics that may exacerbate dehydration
  • Beta‑blockers affecting heart rate
  • Antacids that could alter absorption

Frequently Asked Questions

Nausicalm contains dimenhydrinate and is used to prevent and treat motion‑sickness, vertigo, and nausea or vomiting associated with travel, vestibular disorders, or other acute causes. It is an over‑the‑counter option for adults and children when prescribed by a healthcare professional.

Dimenhydrinate blocks histamine H1 receptors and has anticholinergic activity, which reduces stimulation of the vestibular system and the chemoreceptor trigger zone. This dual action lessens the brain’s response to motion and chemical signals that trigger nausea and vomiting.

The appropriate dose of Nausicalm is determined by the prescriber based on the patient’s age, weight, and clinical situation. Healthcare professionals set the regimen, and patients should follow the specific instructions provided on the prescription label.

Safety data for dimenhydrinate in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk, and this decision must be made by a qualified healthcare provider after evaluating the individual’s circumstances.

To request Nausicalm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with second‑generation antihistamines or newer anti‑emetics such as ondansetron, dimenhydrinate is less selective and may cause more sedation and anticholinergic effects. However, it remains a cost‑effective, widely available option for mild to moderate motion‑related nausea.

Store Nausicalm at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and heat sources to maintain its stability and potency throughout its shelf life.

Nausicalm is taken orally, usually as a tablet, with or without food as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically advised.

Serious risks include severe allergic reactions (rash, angioedema, anaphylaxis), rapid heart rate or arrhythmias, significant confusion or hallucinations, and urinary retention in susceptible individuals. Prompt medical attention is required if any of these symptoms occur.

Individuals with known hypersensitivity to dimenhydrinate or other first‑generation antihistamines should avoid Nausicalm. It is also contraindicated in patients with severe glaucoma, uncontrolled asthma, or certain cardiac conditions unless a physician determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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