Product image of Navalit (Doxylamine Hydrogen Succinate, Pyridoxine Hydrochloride) supplied by GNH India

Navalit

Active Ingredient:
Doxylamine Hydrogen Succinate, Pyridoxine Hydrochloride
Origin:
EU

Navalit (Doxylamine Hydrogen Succinate, Pyridoxine Hydrochloride)

Doxylamine hydrogen succinate and pyridoxine hydrochloride, the active ingredients in Navalit, are an antihistamine (H1 antagonist) and vitamin B6 presented as an oral formulation for use in pregnant women. It alleviates nausea and vomiting of pregnancy (morning sickness).
GNH India supplies Navalit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Effik Benelux

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Indications & Clinical Uses

  • Navalit is used to manage nausea and vomiting associated with pregnancy, acting on the vestibular and neurotransmitter pathways that trigger these symptoms.
  • Nausea and vomiting of pregnancy: reduces frequency and severity of morning sickness.
  • Hyperemesis gravidarum: provides symptomatic relief when conventional measures are insufficient.
  • Pregnancy‑related nausea: helps improve maternal comfort and hydration.

How It Works

  • Doxylamine hydrogen succinate antagonizes peripheral H1 histamine receptors, decreasing vestibular stimulation and the central nausea signal. Pyridoxine hydrochloride serves as a cofactor in the synthesis of neurotransmitters such as serotonin, modulating central pathways that contribute to nausea. The combined action results in reduced perception of nausea and vomiting in pregnant patients.

Side Effects

Navalit may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Drowsiness or sedation
  • Dry mouth
  • Constipation
  • Blurred vision
  • Dizziness
  • Headache

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema)
  • Skin reactions such as Stevens‑Johnson syndrome
  • Hallucinations or confusion
  • Seizures (rare)

Precautions & Warnings

Before initiating Navalit, consider patient‑specific factors and potential risks.

  • Medical history review: assess for glaucoma, asthma, or urinary retention.
  • Alcohol and CNS depressants: avoid concurrent use to reduce excessive sedation.
  • Sedating drugs: monitor closely when combined with benzodiazepines or opioids.
  • Allergies: discontinue if signs of hypersensitivity appear.
  • Pregnancy monitoring: use under medical supervision throughout gestation.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Navalit can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Other sedating antihistamines or CNS depressants: may cause profound drowsiness.
  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Anticholinergic agents: increase risk of dry mouth and urinary retention.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible additive hypotensive effect.
  • Selective serotonin reuptake inhibitors (SSRIs): monitor for serotonin syndrome.
  • Oral contraceptives: may reduce contraceptive efficacy, advise backup method.

Frequently Asked Questions

Navalit is an oral combination of doxylamine hydrogen succinate and pyridoxine hydrochloride indicated for the treatment of nausea and vomiting associated with pregnancy, commonly known as morning sickness or hyperemesis gravidarum.

Doxylamine hydrogen succinate blocks H1 histamine receptors in the central nervous system, reducing vestibular stimulation that contributes to nausea. This antihistaminic effect, together with pyridoxine’s role as a vitamin B6 cofactor, helps alleviate pregnancy‑related nausea.

The dosage of Navalit is determined by the prescribing clinician based on the individual’s clinical condition, severity of symptoms, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Navalit is specifically formulated for use in pregnancy and is considered safe when prescribed by a qualified health professional. Limited data are available for breastfeeding; clinicians should weigh potential benefits against any possible risks before recommending use.

To order Navalit, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Navalit combines an antihistamine with vitamin B6, offering a dual mechanism that can be more effective for some patients than single‑agent therapies such as ondansetron or metoclopramide. Its safety profile in pregnancy is well‑established, making it a preferred first‑line option in many guidelines.

Navalit should be stored at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct light. Keep the product out of reach of children and do not use after the expiry date printed on the label.

Navalit is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, skin disorders like Stevens‑Johnson syndrome, and neurological events such as seizures or hallucinations. Patients should seek immediate medical attention if they experience any of these symptoms.

Navalit is contraindicated in individuals with known hypersensitivity to doxylamine, pyridoxine, or any excipients in the formulation. It should also be avoided in patients with uncontrolled glaucoma, severe asthma, or urinary retention unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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