Product image of Navirel (Vinorelbine) supplied by GNH India

Navirel

Active Ingredient:
Vinorelbine
Origin:
EU

Navirel (Vinorelbine)

Vinorelbine, the active ingredient in Navirel, is a Vinca alkaloid presented as an injectable solution for intravenous infusion. It is used in oncology to treat certain advanced solid tumours, primarily in adult patients with non‑small cell lung cancer or metastatic breast cancer.

GNH India supplies Navirel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Medac Gesellschaft Für Klinische Spezialpräparate Mbh (Wedel)

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Indications & Clinical Uses

  • Vinorelbine is a chemotherapy agent that interferes with microtubule dynamics in malignant cells, making it useful in specific solid‑tumour protocols.
  • Non‑small cell lung cancer: used as part of combination chemotherapy to inhibit tumour growth and improve progression‑free survival.
  • Metastatic breast cancer: administered in combination regimens to control disease spread and extend overall survival.

How It Works

  • Vinorelbine binds to tubulin, preventing microtubule polymerisation during mitosis. This disruption halts the formation of the mitotic spindle, leading to cell‑cycle arrest at the metaphase stage and ultimately triggering apoptosis of rapidly dividing cancer cells.

Side Effects

Vinorelbine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Neutropenia: reduced white‑blood‑cell count increasing infection risk.
  • Anemia: lowered red‑blood‑cell levels causing fatigue.
  • Nausea and vomiting: gastrointestinal upset common with chemotherapy.
  • Constipation: reduced bowel motility.
  • Alopecia: hair loss during treatment.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Severe neutropenic infection: febrile neutropenia requiring urgent care.
  • Peripheral neuropathy: nerve damage causing tingling or numbness.
  • Pulmonary toxicity: interstitial pneumonitis or fibrosis.
  • Hypersensitivity reactions: rash, bronchospasm, or anaphylaxis.
  • Cardiac arrhythmia: irregular heart rhythm in susceptible patients.

Precautions & Warnings

  • Vinorelbine requires careful monitoring and specific safety measures before and during therapy.
  • Monitor blood counts: perform regular CBC to detect neutropenia.
  • Assess liver function: adjust dosing in hepatic impairment.
  • Avoid concurrent myelosuppressive agents: increased risk of bone‑marrow suppression.
  • Use antiemetics prophylactically: reduce nausea and vomiting.
  • Pregnancy: contraindicated or unknown; avoid use in pregnant women.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Vinorelbine can interact with several drug classes, influencing efficacy or toxicity.

Major Interactions (Avoid)

  • Concurrent Vinca alkaloids: additive myelosuppression.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increased vinorelbine exposure.
  • Live vaccines: risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin): reduced drug levels.
  • Anticoagulants (e.g., warfarin): potential bleeding risk.
  • NSAIDs: may exacerbate thrombocytopenia.

Frequently Asked Questions

Navirel contains vinorelbine, an antineoplastic agent indicated for the treatment of adult patients with non‑small cell lung cancer and metastatic breast cancer, typically as part of combination chemotherapy regimens.

Vinorelbine interferes with microtubule assembly by binding to tubulin, preventing polymerisation. This blocks mitotic spindle formation, arrests cells in metaphase, and induces apoptosis of rapidly dividing cancer cells.

The specific dose and schedule of Navirel are determined by the treating oncologist based on the patient’s condition, body surface area, and treatment protocol. Dosing is individualized and not publicly standardized.

Safety data for vinorelbine in pregnancy and lactation are limited. It is generally avoided in pregnant or nursing women because of potential fetal toxicity and unknown excretion in breast milk.

To request Navirel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Compared with other Vinca alkaloids such as vincristine, vinorelbine has a distinct toxicity profile, with more pronounced myelosuppression but less neurotoxicity. Its efficacy in lung and breast cancer is well‑documented, making it a preferred option in many combination protocols.

Navirel must be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the vial. Before administration, inspect for particulate matter and ensure aseptic technique.

Navirel is supplied as an injectable solution for intravenous infusion. It is administered by a qualified healthcare professional, usually over a period of 6–10 minutes, following standard infusion protocols and pre‑medication to mitigate nausea.

The most serious risks include severe neutropenia leading to infection, pulmonary toxicity such as interstitial pneumonitis, and rare hypersensitivity reactions. Patients should be monitored closely for signs of infection, respiratory distress, or allergic response.

Navirel is contraindicated in patients with known hypersensitivity to vinorelbine or other Vinca alkaloids, those with severe bone‑marrow suppression, uncontrolled infections, or significant hepatic impairment. Caution is also advised for pregnant or nursing women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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