Product image of Nazopass (Oxymetazoline Hydrochloride) supplied by GNH India

Nazopass

Active Ingredient:
Oxymetazoline Hydrochloride
Origin:
EU

Nazopass (Oxymetazoline Hydrochloride)

Oxymetazoline Hydrochloride, the active ingredient in Nazopass, is a alpha-adrenergic agonist presented as a nasal decongestant for nasal use. It relieves nasal congestion associated with the common cold, sinusitis, and allergic rhinitis in adults and children.

GNH India supplies Nazopass as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

  • Nazopass, an alpha‑adrenergic agonist nasal decongestant, is used to treat conditions that cause nasal blockage.
  • Common cold: reduces nasal congestion by vasoconstriction of nasal mucosal vessels.
  • Sinusitis: alleviates blockage and improves sinus drainage.
  • Allergic rhinitis: relieves nasal stuffiness caused by allergic inflammation.

How It Works

  • Oxymetazoline Hydrochloride acts as a selective alpha‑1 and alpha‑2 adrenergic receptor agonist. Stimulation of these receptors on the vascular smooth muscle of the nasal mucosa produces vasoconstriction, decreasing blood flow, reducing mucosal edema, and thereby opening the nasal airway for improved airflow.

Side Effects

Oxymetazoline Hydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nasal irritation or burning sensation
  • Dryness of the nasal mucosa
  • Sneezing
  • Mild headache

Serious or Rare Side Effects

  • Elevated blood pressure or hypertension
  • Tachycardia or irregular heart rhythm
  • Rebound nasal congestion (rhinitis medicamentosa) with prolonged use
  • Severe allergic reactions such as rash or angioedema

Precautions & Warnings

  • Use Nazopass with awareness of specific safety considerations.
  • Pregnancy: safety not established; consult a healthcare professional before use.
  • Breastfeeding: unknown safety profile; use only if benefit outweighs potential risk.
  • Age restrictions: not recommended for children under 6 years unless directed by a clinician.
  • Concurrent nasal surgery: avoid use immediately before or after procedures involving the nasal passages.
  • Avoid prolonged use: limit to 3‑5 days to prevent rebound congestion.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Oxymetazoline may interact with other sympathomimetic agents and cardiovascular drugs.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may increase hypertensive response.
  • Other nasal decongestants: additive vasoconstriction risk.
  • Sympathomimetic drugs (e.g., ephedrine): may cause excessive cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: may reduce blood‑pressure‑lowering effect.
  • Beta‑blockers: may mask tachycardia signs.
  • Tricyclic antidepressants: potential additive cardiovascular effects.

Frequently Asked Questions

Nazopass is indicated for temporary relief of nasal congestion caused by the common cold, sinusitis, and allergic rhinitis. It works by narrowing the blood vessels in the nasal lining, which reduces swelling and opens the airway for easier breathing.

Oxymetazoline hydrochloride is a selective alpha‑1 and alpha‑2 adrenergic receptor agonist. When applied to the nasal mucosa, it triggers vasoconstriction of the small blood vessels, decreasing mucosal edema and allowing the nasal passages to clear.

The appropriate dose of Nazopass is determined by a qualified prescriber based on the patient’s age, condition, and response. The product is intended for short‑term use, typically not exceeding three to five consecutive days.

Safety data for oxymetazoline hydrochloride in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk, and only after consultation with a healthcare professional.

To place an order, submit an enquiry on the Nazopass product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nazopass contains oxymetazoline, a potent alpha‑adrenergic agonist that provides rapid relief of congestion. Compared with older agents such as phenylephrine, oxymetazoline generally offers a longer duration of action and a lower incidence of rebound congestion when used as directed.

Nazopass should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid storing it in bathrooms or other humid environments.

Nazopass is applied intranasally. The recommended technique is to tilt the head slightly forward, insert the tip into one nostril, and spray the prescribed number of sprays. Repeat in the other nostril if directed, and avoid blowing the nose immediately after administration.

Serious risks, though uncommon, include significant elevation of blood pressure, rapid heart rate, arrhythmias, and rebound nasal congestion (rhinitis medicamentosa) after prolonged use. Patients experiencing these symptoms should discontinue use and seek medical attention promptly.

Nazopass should be avoided by individuals with known hypersensitivity to oxymetazoline or any excipients, patients with severe hypertension, coronary artery disease, or uncontrolled cardiovascular disorders, and children under six years of age unless specifically prescribed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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