Product image of Nebicina Flaconcino (Tobramycin) supplied by GNH India

Nebicina Flaconcino

Active Ingredient:
Tobramycin
Origin:
EU

Nebicina Flaconcino (Tobramycin)

Tobramycin, the active ingredient in Nebicina Flaconcino, is an aminoglycoside antibiotic presented as an injectable solution for intramuscular and intravenous use. It treats severe infections caused by susceptible Gram‑negative bacteria, including Pseudomonas aeruginosa, and is employed in complicated urinary and respiratory tract infections.

GNH India supplies Nebicina Flaconcino as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, and pharmacies worldwide. We adhere to stringent quality standards and provide comprehensive technical support.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

Nebicina Flaconcino (tobramycin) is used to treat infections caused by Gram‑negative bacteria, particularly in serious systemic disease.

  • Severe Gram‑negative bacterial infections: achieves bacterial eradication in life‑threatening conditions.
  • Pseudomonas aeruginosa infections: provides effective coverage against this resistant pathogen.
  • Complicated urinary tract infections: clears infection when oral agents are insufficient.
  • Respiratory tract infections: treats severe lower respiratory infections caused by susceptible organisms.

How It Works

  • Tobramycin binds to the 30S subunit of bacterial ribosomes, causing misreading of messenger RNA and premature termination of protein synthesis. This inhibition of translation leads to bactericidal activity against susceptible Gram‑negative organisms, including Pseudomonas species. Its concentration‑dependent killing is optimized by achieving high peak plasma levels, and it is eliminated primarily unchanged by renal excretion, allowing dose adjustments based on kidney function.

Side Effects

Tobramycin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nephrotoxicity: reversible increase in serum creatinine or reduced urine output.
  • Ototoxicity: transient hearing changes or tinnitus.
  • Injection site reactions: pain, erythema, or swelling at the administration site.
  • Fever: mild temperature elevation.
  • Rash: mild skin eruption.

Serious or Rare Side Effects

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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