Product image of Nebido (Testosterone Undecanoate) supplied by GNH India

Nebido

Active Ingredient:
Testosterone Undecanoate
Origin:
EU

Nebido (Testosterone Undecanoate)

Testosterone undecanoate, the active ingredient in Nebido, is an androgen presented as a 1000 mg/mL intramuscular injection solution for intramuscular use. It replaces deficient endogenous testosterone in adult men with hypogonadism and testosterone deficiency. Nebido is indicated for androgen replacement therapy to restore physiological hormone levels.

GNH India supplies Nebido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grünenthal Gmbh

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Indications & Clinical Uses

Nebido (testosterone undecanoate) is used in androgen replacement therapy to restore normal testosterone levels in men.

  • Male hypogonadism: restores physiological testosterone concentrations and alleviates associated symptoms such as fatigue, loss of libido, and reduced muscle mass.
  • Testosterone deficiency: provides exogenous testosterone to compensate for inadequate endogenous production.
  • Androgen deficiency syndrome: improves secondary sexual characteristics and overall quality of life in affected males.

How It Works

  • Testosterone undecanoate is hydrolyzed after intramuscular administration to release testosterone, which binds to intracellular androgen receptors. The hormone‑receptor complex translocates to the nucleus, modulating gene transcription that regulates male sexual development, anabolic processes, and maintenance of secondary sexual characteristics.

Side Effects

Nebido may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Injection site pain or erythema
  • Headache
  • Acne or oily skin
  • Increased hematocrit
  • Fluid retention or edema
  • Mood changes

Serious or Rare Side Effects

  • Polycythemia leading to thrombosis
  • Cardiovascular events such as myocardial infarction
  • Prostate enlargement or cancer progression
  • Severe hypertension
  • Allergic reactions including anaphylaxis
  • Liver function abnormalities

Precautions & Warnings

Before initiating Nebido, clinicians should consider several safety measures.

  • Screen for prostate disease: assess prostate-specific antigen and digital exam.
  • Monitor hematocrit: periodic blood tests to detect polycythemia.
  • Evaluate cardiovascular risk: use caution in patients with known heart disease.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Contraindicated in women and children: not indicated for pregnancy or lactation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nebido can interact with several medications; awareness of interaction severity guides management.

Major Interactions (Avoid)

  • Warfarin: may potentiate anticoagulant effect and increase bleeding risk.
  • Insulin: testosterone can alter glucose metabolism, requiring dose adjustments.
  • Strong CYP3A4 inhibitors: may raise testosterone levels and risk of adverse effects.
  • Glucocorticoids: may diminish the therapeutic response of testosterone.
  • Estrogen therapy: antagonistic hormonal actions may reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: blood pressure may change, necessitating monitoring.
  • Statins: potential for increased liver enzyme elevations; regular liver function tests advised.

Frequently Asked Questions

Nebido is prescribed for androgen replacement therapy in adult men who have clinically confirmed hypogonadism or testosterone deficiency. By providing a long‑acting source of testosterone, it helps alleviate symptoms such as reduced libido, fatigue, loss of muscle mass, and mood disturbances.

Testosterone undecanoate is a prodrug that, after intramuscular injection, is slowly hydrolyzed to testosterone. The released hormone binds to androgen receptors in target cells, influencing gene expression that regulates male sexual development, anabolic functions, and maintenance of secondary sexual characteristics.

The dosing regimen for Nebido is determined by the prescribing clinician based on the patient’s clinical status, testosterone levels, and response to therapy. Typically, the medication is administered by a healthcare professional as an intramuscular injection, and the exact schedule should follow the prescriber’s instructions.

Nebido is not indicated for use in women, and its safety in pregnancy or lactation has not been established. It is contraindicated for pregnant or nursing individuals, and women of childbearing potential should avoid exposure unless a clear medical need is established by a qualified physician.

To request Nebido, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including cold‑chain handling if needed—and necessary import documentation.

Nebido provides a prolonged release of testosterone, typically requiring fewer injections (every 10–14 weeks) compared with shorter‑acting esters such as testosterone enanthate or cypionate, which often need weekly or bi‑weekly dosing. This reduced injection frequency can improve patient convenience, though individual response and side‑effect profiles may vary.

Nebido should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use, and discard any vial that shows signs of contamination or damage.

Nebido is given as an intramuscular injection, usually into the gluteal muscle, by a qualified healthcare professional. The injection is performed using aseptic technique, and the prescribed dosing interval is followed to maintain stable testosterone levels.

Serious risks associated with Nebido include polycythemia, which can increase the chance of blood clots, cardiovascular events such as myocardial infarction, worsening of prostate disease, severe hypertension, and rare allergic reactions. Regular monitoring of blood counts, prostate health, and cardiovascular status is essential.

Nebido is contraindicated in women, children, and men with known or suspected prostate cancer, severe untreated sleep apnea, uncontrolled heart failure, or a history of severe allergic reactions to testosterone undecanoate. Patients with significant cardiovascular disease should be evaluated carefully before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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