Product image of Nebido (Testosterone Undecanoate) supplied by GNH India

Nebido

Active Ingredient:
Testosterone Undecanoate
Origin:
EU

Nebido (Testosterone Undecanoate)

Testosterone undecanoate, the active ingredient in Nebido, is an androgen; anabolic steroid presented as a 1000 mg/4 mL oil solution for intramuscular use. It treats male hypogonadism and testosterone deficiency in adult men and is administered by deep intramuscular injection providing sustained release of testosterone over several weeks.

GNH India supplies Nebido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grünenthal Gmbh

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Indications & Clinical Uses

Nebido (testosterone undecanoate) is used in hormone replacement therapy to restore normal testosterone levels.

  • Male hypogonadism: restores physiological testosterone concentrations and alleviates symptoms such as low libido, fatigue, and reduced muscle mass.
  • Testosterone deficiency: supports development of secondary sexual characteristics, improves bone density and mood.
  • Low testosterone levels: enhances energy, mood, and sexual function in men with clinically confirmed low serum testosterone.

How It Works

  • Nebido is a prodrug of testosterone; after intramuscular injection the undecanoate ester is hydrolyzed, releasing testosterone. The liberated hormone binds to intracellular androgen receptors, modulating gene transcription that drives androgenic and anabolic processes, thereby correcting the hormonal deficit in hypogonadal men.

Side Effects

Nebido may cause a range of adverse reactions. The most frequently reported are generally mild and reversible.

Common Side Effects

  • Injection site pain or bruising
  • Swelling or erythema at the injection site
  • Acne or oily skin
  • Increased red blood cell count (polycythemia)
  • Fluid retention or peripheral edema
  • Headache

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Significant polycythemia leading to thrombosis
  • Liver toxicity or elevated liver enzymes
  • Cardiovascular events such as myocardial infarction
  • Prostate enlargement or exacerbation of prostate disease
  • Testicular atrophy or infertility

Precautions & Warnings

Before initiating Nebido therapy, clinicians should evaluate several safety parameters.

  • Monitor hematocrit: check blood counts regularly to detect polycythemia.
  • Assess prostate health: perform digital rectal exam and PSA testing.
  • Evaluate cardiovascular risk: consider history of heart disease or stroke.
  • Avoid use in patients with known hypersensitivity to testosterone or formulation components.
  • Use caution in individuals with sleep‑apnea or uncontrolled hypertension.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nebido can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Warfarin or other oral anticoagulants: increased bleeding risk.
  • Insulin or oral hypoglycemics: may require dose adjustment due to altered glucose metabolism.
  • Corticosteroids: can exacerbate fluid retention and hypertension.
  • 5‑alpha‑reductase inhibitors: may affect androgen metabolism.
  • GnRH analogues: can blunt the intended hormonal effect.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: monitor blood pressure for additive effects.
  • Diuretics: watch for electrolyte disturbances.
  • Lipid‑lowering drugs (statins): monitor liver function.
  • Antidepressants (SSRIs): observe for mood changes.
  • Anticonvulsants: may affect testosterone metabolism.

Frequently Asked Questions

Nebido is prescribed for adult men with male hypogonadism or clinically confirmed testosterone deficiency. It provides long‑acting testosterone replacement to alleviate symptoms such as low libido, fatigue, loss of muscle mass, and decreased bone density.

Testosterone undecanoate is a prodrug that, after intramuscular injection, is hydrolyzed to testosterone. The active hormone binds to androgen receptors, influencing gene expression that drives androgenic and anabolic effects, thereby restoring normal hormonal balance in hypogonadal patients.

The exact dosing regimen for Nebido is determined by the prescribing clinician based on the patient’s serum testosterone levels, clinical response, and individual health factors. The product is supplied as a 1000 mg/4 mL oil solution for intramuscular injection.

Nebido is not indicated for use in women, and its safety in pregnancy or breastfeeding has not been established. It should be avoided in these populations, and women of child‑bearing potential should use effective contraception during treatment.

To order Nebido, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Nebido offers a prolonged dosing interval, typically requiring injection every 10‑14 weeks, compared with shorter‑acting testosterone esters that may need weekly or bi‑weekly dosing. This reduces clinic visits and improves adherence, while providing comparable efficacy in restoring testosterone levels.

Nebido should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability and potency.

Nebido is administered as a deep intramuscular injection, usually into the gluteal muscle. The injection is performed by a qualified healthcare professional using aseptic technique, and the dosing schedule is set by the prescriber.

Serious risks include significant polycythemia, which can increase the chance of blood clots, severe allergic reactions, cardiovascular events such as myocardial infarction, and potential worsening of prostate disease. Patients should be monitored regularly for these complications.

Nebido is contraindicated in men with known hypersensitivity to testosterone undecanoate or any formulation component, those with prostate or breast cancer, severe untreated sleep‑apnea, uncontrolled heart failure, or active thromboembolic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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