Product image of Nebido (Testosterone Undecanoate) supplied by GNH India

Nebido

Active Ingredient:
Testosterone Undecanoate
Origin:
EU

Nebido (Testosterone Undecanoate)

Testosterone undecanoate, the active ingredient in Nebido, is an androgenic anabolic steroid presented as a 1000 mg/3 mL vial for intramuscular use. It provides sustained release of testosterone after injection and is used to treat male hypogonadism, testosterone deficiency, and delayed puberty in males.

GNH India supplies Nebido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grünenthal Pharmaceuticals Gmbh & Co. Kg

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Indications & Clinical Uses

Nebido, a long‑acting testosterone replacement, is used in conditions related to androgen deficiency.

  • Male hypogonadism: restores normal testosterone levels and alleviates symptoms such as low libido, fatigue, and loss of muscle mass.
  • Testosterone deficiency: improves energy, mood, and bone density in men with documented low serum testosterone.
  • Delayed puberty in males: supports the development of secondary sexual characteristics and normal growth.

How It Works

  • Testosterone undecanoate is a prodrug that, after intramuscular injection, is slowly hydrolyzed to testosterone. The released testosterone binds intracellular androgen receptors, modulating gene transcription that promotes anabolic and androgenic effects, including protein synthesis, erythropoiesis, and maintenance of secondary sexual characteristics.

Side Effects

Nebido may be associated with a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Acne: increased sebaceous gland activity leading to skin eruptions.
  • Fluid retention: mild edema, especially in lower extremities.
  • Increased hematocrit: elevated red blood cell count.

Serious or Rare Side Effects

  • Cardiovascular events: myocardial infarction or stroke.
  • Liver toxicity: abnormal liver function tests or hepatitis.
  • Polycythemia: excessive increase in red blood cell mass.
  • Allergic reactions: anaphylaxis or severe hypersensitivity.

Precautions & Warnings

Before initiating Nebido, several safety considerations should be reviewed.

  • Cardiovascular assessment: evaluate history of heart disease before initiating therapy.
  • Hematocrit monitoring: check blood counts regularly to detect polycythemia.
  • Prostate evaluation: screen for prostate cancer or benign hyperplasia prior to treatment.
  • Sleep apnea screening: assess for obstructive sleep apnea as testosterone may worsen it.
  • Fertility considerations: discuss potential impact on spermatogenesis with patients desiring fertility.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nebido can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Anticoagulants: testosterone may enhance pro‑coagulant effects, increasing thrombosis risk.
  • Corticosteroids: combined use can exacerbate fluid retention and hypertension.
  • Insulin or oral hypoglycemics: testosterone may alter glucose metabolism, requiring dose adjustments.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase testosterone levels.
  • Warfarin: monitor INR as testosterone can affect clotting parameters.
  • GnRH analogues: concurrent use may blunt testosterone’s intended effects.

Frequently Asked Questions

Nebido is indicated for the treatment of male hypogonadism, testosterone deficiency, and delayed puberty in males. In each condition it aims to restore physiological testosterone levels, improve symptoms such as low libido, fatigue, reduced muscle mass, and support normal development of secondary sexual characteristics.

Testosterone undecanoate is a long‑acting prodrug. After intramuscular injection it is gradually hydrolyzed to testosterone, which then binds intracellular androgen receptors. This binding triggers gene transcription that promotes anabolic processes, erythropoiesis, and the maintenance of male secondary sexual characteristics.

The prescribing physician determines the dose and injection interval based on the individual’s clinical condition, serum testosterone levels, and response to therapy. Dosing is individualized and should follow the healthcare professional’s recommendation.

Nebido is not indicated for use in women, and its safety in pregnancy or breastfeeding is unknown. It should be avoided in these populations, and women of child‑bearing potential should use effective contraception while receiving testosterone therapy.

To order Nebido, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Nebido provides a much longer dosing interval than short‑acting injectables such as testosterone enanthate or cypionate, which often require weekly or bi‑weekly injections. Compared with transdermal gels, Nebido eliminates daily application but requires intramuscular administration. The choice depends on patient preference, adherence, and clinical considerations.

Nebido should be stored at 2‑8 °C (refrigerated), protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any product that has been exposed to temperatures outside the recommended range.

Nebido is given as an intramuscular injection, typically into a deep gluteal muscle. The injection should be performed by a qualified healthcare professional using aseptic technique. The volume per vial is 3 mL, containing 1000 mg of testosterone undecanoate.

Serious risks include cardiovascular events such as myocardial infarction or stroke, polycythemia (excessive rise in red blood cell mass), liver toxicity, and potential aggravation of pre‑existing prostate cancer. Patients should be monitored regularly for these conditions, and therapy should be discontinued if severe adverse events occur.

Nebido is contraindicated in individuals with known hypersensitivity to testosterone undecanoate, active prostate or breast cancer, severe untreated sleep apnea, uncontrolled hypertension, or a hematocrit above the normal range. It should also be avoided in women, especially during pregnancy or lactation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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