Product image of Nebido (Testosterone Undecanoate) supplied by GNH India

Nebido

Active Ingredient:
Testosterone Undecanoate
Origin:
EU

Nebido (Testosterone Undecanoate)

Testosterone undecanoate, the active ingredient in Nebido, is an androgenic anabolic steroid presented as an intramuscular injection for intramuscular use. It is used to treat male hypogonadism, testosterone deficiency, and as part of hormone replacement therapy in adult men.

GNH India supplies Nebido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grünenthal Gmbh

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Indications & Clinical Uses

Nebido provides exogenous testosterone for conditions related to low endogenous hormone production.

  • Male hypogonadism: restores normal testosterone levels and improves symptoms such as fatigue, low libido, and reduced muscle mass.
  • Testosterone deficiency: supports physiological functions and helps maintain secondary sexual characteristics.
  • Hormone replacement therapy: used in adult men requiring long‑term testosterone supplementation to sustain normal endocrine balance.

How It Works

  • Testosterone undecanoate is hydrolyzed after intramuscular administration to release testosterone, which binds to intracellular androgen receptors. The hormone‑receptor complex translocates to the nucleus, where it binds androgen‑responsive elements on DNA, modulating transcription of genes that regulate male sexual development, protein synthesis, erythropoiesis, and metabolic processes.

Side Effects

Nebido may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Acne or oily skin: increased sebaceous gland activity.
  • Fluid retention: mild edema, especially in lower extremities.
  • Increased red blood cell count: polycythemia risk.
  • Mood changes: irritability or aggression.
  • Decreased sperm production: transient reduction in spermatogenesis.

Serious or Rare Side Effects

  • Cardiovascular events: thromboembolism or myocardial infarction.
  • Hepatic dysfunction: elevated liver enzymes or cholestasis.
  • Prostate abnormalities: rapid growth or elevated PSA.
  • Allergic reactions: rash, urticaria, or anaphylaxis.

Precautions & Warnings

Nebido requires careful clinical monitoring and patient education.

  • Baseline assessment: evaluate testosterone levels, hematocrit, and prostate health before initiating therapy.
  • Cardiovascular risk: monitor blood pressure, lipid profile, and signs of thromboembolic disease.
  • Liver function: check hepatic enzymes periodically.
  • Hematocrit monitoring: adjust dose if hematocrit exceeds recommended limits.
  • Contraindications: avoid in patients with known hypersensitivity to testosterone undecanoate.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nebido can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of thrombosis.
  • Insulin or oral hypoglycemics: may enhance glucose‑lowering effect, risking hypoglycemia.
  • CYP3A4 inhibitors (e.g., ketoconazole): can raise testosterone levels, increasing side‑effect risk.

Moderate Interactions (Monitor Closely)

  • Glucocorticoids: may blunt anabolic effects of testosterone.
  • Diuretics: can exacerbate fluid retention.
  • Anti‑androgen therapies: reduce therapeutic efficacy of testosterone.

Frequently Asked Questions

Nebido is prescribed for adult men with male hypogonadism, testosterone deficiency, or those requiring hormone replacement therapy. It provides a long‑acting source of testosterone to restore normal hormonal levels and alleviate associated symptoms such as low libido, fatigue, and reduced muscle mass.

After intramuscular injection, testosterone undecanoate is slowly hydrolyzed to testosterone. The hormone binds to intracellular androgen receptors, forming a complex that moves into the cell nucleus and regulates gene transcription. This process supports the development and maintenance of male secondary sexual characteristics and metabolic functions.

The dosing regimen for Nebido is individualized by the prescribing healthcare professional based on the patient’s clinical condition, serum testosterone levels, and response to therapy. The prescriber determines the appropriate dose and injection interval.

Nebido is not indicated for use in pregnant or breastfeeding individuals. Testosterone therapy can affect fetal development and may be transferred to infants through breast milk, potentially causing hormonal disturbances. Women who are pregnant, planning pregnancy, or nursing should avoid exposure.

To request Nebido, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including cold‑chain handling if needed—and necessary import documentation.

Nebido offers a long‑acting intramuscular formulation that requires fewer injections (typically every 10–14 weeks) compared with shorter‑acting testosterone esters that may need weekly or bi‑weekly dosing. This can improve patient adherence, but the choice of product depends on individual clinical needs, tolerability, and physician preference.

Nebido should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vials. If temporary temperature excursions occur, keep the product out of direct sunlight and return it to proper refrigeration as soon as possible.

Nebido is given by deep intramuscular injection, usually into the gluteal muscle. The injection is performed by a qualified healthcare professional using aseptic technique. The initial dose is followed by a maintenance schedule determined by the prescriber, often spaced several weeks apart.

Serious risks include cardiovascular events such as myocardial infarction or thromboembolism, hepatic dysfunction, and rapid progression of prostate disease. Patients should be monitored regularly for signs of these conditions, and therapy should be discontinued if severe adverse reactions occur.

Nebido is contraindicated in individuals with known hypersensitivity to testosterone undecanoate, active prostate or breast cancer, severe untreated sleep apnea, uncontrolled heart failure, or those at high risk for thromboembolic disease. It should also be avoided in women, especially during pregnancy or lactation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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