Product image of Nebilet (Nebivolol) supplied by GNH India

Nebilet

Active Ingredient:
Nebivolol
Origin:
EU

Nebilet (Nebivolol)

Nebivolol, the active ingredient in Nebilet, is a beta blocker presented as an oral tablet for oral use. It is prescribed to lower high blood pressure and to improve outcomes in patients with heart failure.

GNH India supplies Nebilet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Nebilet (nebivolol) is used in cardiovascular conditions that involve elevated blood pressure or impaired cardiac function.

  • Hypertension: lowers systolic and diastolic blood pressure, helping to reduce the risk of stroke and cardiovascular events.
  • Heart failure: improves left‑ventricular ejection fraction and reduces hospitalization rates in patients with chronic heart failure.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility. In addition, it stimulates endothelial nitric oxide synthase, leading to nitric‑oxide‑mediated vasodilation. This dual action reduces systemic vascular resistance and arterial pressure while preserving cardiac output, making it effective for hypertension and heart‑failure management.

Side Effects

Nebivolol may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue
  • Headache
  • Dizziness
  • Bradycardia
  • Nausea
  • Peripheral edema

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Acute decompensated heart failure
  • Bronchospasm in patients with asthma or COPD
  • Hepatic injury
  • Allergic reactions such as rash or angioedema
  • Cardiogenic shock

Precautions & Warnings

When prescribing Nebilet, several safety considerations should be observed.

  • Cardiovascular assessment: evaluate heart rate and blood pressure before initiating therapy.
  • Renal impairment: adjust use in patients with severe kidney disease.
  • Hepatic dysfunction: monitor liver function tests during treatment.
  • Concomitant drugs: avoid use with other β‑blockers or calcium‑channel blockers that may cause excessive bradycardia.
  • Pregnancy and lactation: use only if potential benefit justifies risk; discuss with healthcare provider.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and light.

Avoid Interactions

Nebivolol can interact with other medicines; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., paroxetine, quinidine): may increase nebivolol plasma levels.
  • Other β‑blockers: additive bradycardia and hypotension.
  • Non‑dihydropyridine calcium‑channel blockers (verapamil, diltiazem): risk of severe bradycardia.
  • Insulin or oral hypoglycemics: may mask hypoglycemia symptoms.
  • Clonidine: abrupt discontinuation after nebivolol can cause rebound hypertension.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive effect.
  • Diuretics: monitor electrolytes and blood pressure.
  • Other antihypertensives: titrate dose to avoid excessive hypotension.
  • SSRIs (e.g., fluoxetine): may modestly increase nebivolol levels.
  • Digoxin: monitor for bradyarrhythmias.

Frequently Asked Questions

Nebilet contains nebivolol, a beta‑blocker indicated for the treatment of essential hypertension and for chronic heart failure. In hypertension it helps lower blood pressure, while in heart failure it improves cardiac output and reduces the risk of hospitalization.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. It also enhances endothelial nitric‑oxide production, causing vasodilation. This combination lowers systemic vascular resistance and arterial pressure, providing antihypertensive and heart‑failure benefits.

The dose of Nebilet is individualized by the prescribing clinician based on the patient’s blood pressure, heart‑failure status, age, renal function and other medications. The prescriber determines the appropriate strength and titration schedule for each patient.

Nebivolol is classified as a pregnancy‑category drug only when the potential benefit outweighs the risk. It should be used during pregnancy or lactation only under direct medical supervision, and the prescriber should discuss possible effects with the patient.

To request Nebilet, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nebivolol is a highly β1‑selective blocker with additional nitric‑oxide‑mediated vasodilation, which may result in fewer metabolic side effects compared with non‑selective beta blockers. Its dual mechanism can offer better blood‑pressure control and improved tolerability in some patients.

Nebilet tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Nebilet is taken orally, usually once daily, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious adverse events include severe bradycardia, heart block, acute decompensated heart failure, bronchospasm in patients with asthma or COPD, and rare cases of hepatic injury or allergic reactions. Patients should seek immediate medical attention if they experience fainting, severe shortness of breath, or signs of liver dysfunction.

Nebilet is contraindicated in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia (heart rate <50 bpm), second‑ or third‑degree atrioventricular block without a pacemaker, and in individuals with uncompensated heart failure or cardiogenic shock.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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