Product image of Nebilet (Nebivolol) supplied by GNH India

Nebilet

Active Ingredient:
Nebivolol
Origin:
EU

Nebilet (Nebivolol)

Nebivolol, the active ingredient in Nebilet, is a beta blocker presented as a tablet for oral use. It treats hypertension and heart failure in adult patients, helping to lower blood pressure and improve cardiac function.
GNH India supplies Nebilet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Nebivolol is indicated for conditions within the cardiovascular disease spectrum, primarily affecting blood pressure regulation and cardiac performance.
  • Hypertension: lowers systolic and diastolic blood pressure, reducing the risk of cardiovascular events.
  • Heart failure: enhances left‑ventricular ejection fraction and decreases hospitalisation rates in patients with chronic heart failure.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, reducing heart rate and contractility. In addition, it stimulates endothelial nitric oxide synthase, increasing nitric oxide release, which causes vasodilation and further contributes to blood‑pressure reduction without significant β2 antagonism.

Side Effects

Nebivolol may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Fatigue or tiredness
  • Headache
  • Dizziness or light‑headedness
  • Mild nausea

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with asthma or COPD
  • Allergic reactions such as rash, angioedema, or anaphylaxis

Precautions & Warnings

When prescribing Nebivolol, clinicians should consider several safety measures.

  • Monitor blood pressure: check regularly to avoid excessive lowering.
  • Assess heart rate: watch for bradycardia, especially in patients with conduction disorders.
  • Caution in asthma/COPD: β‑blockade may exacerbate bronchospasm.
  • Avoid abrupt discontinuation: sudden stop can precipitate rebound hypertension.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Nebivolol can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: additive bradycardia and AV‑block risk.
  • Calcium‑channel blockers (verapamil, diltiazem): increased risk of severe bradycardia and heart block.
  • Other antihypertensives (ACE inhibitors, ARBs, diuretics): may cause excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor electrolytes and renal function.
  • Antidiabetic agents: beta‑blockade may mask hypoglycaemia symptoms, requiring glucose monitoring.

Frequently Asked Questions

Nebilet, containing nebivolol, is prescribed for adult patients with hypertension and chronic heart failure. In hypertension, it helps lower elevated blood‑pressure readings, while in heart failure it improves cardiac output and reduces the likelihood of hospitalisation.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractile force. It also stimulates nitric‑oxide release from the endothelium, causing vasodilation. The combined effect reduces systemic vascular resistance and lowers blood pressure.

The appropriate dose of Nebilet is determined by the prescribing healthcare professional based on the individual’s clinical condition, response, and tolerability. Dosage adjustments may be required for specific patient groups, and the prescriber will provide the exact regimen.

Nebivolol’s safety in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Nebilet, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nebilet (nebivolol) is a third‑generation β1‑selective blocker that also enhances nitric‑oxide‑mediated vasodilation, offering a more favourable metabolic profile and fewer central nervous system side effects compared with older non‑selective beta‑blockers such as propranolol.

Nebilet tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and do not use after the expiry date.

Nebilet is taken orally as a tablet, usually with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks include severe bradycardia, marked hypotension, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as angioedema. Patients experiencing these symptoms should seek immediate medical attention.

Nebilet is contraindicated in patients with known hypersensitivity to nebivolol, those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and individuals with uncompensated heart failure or severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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