Product image of Nebiphar (Nebivolol Hydrochloride) supplied by GNH India

Nebiphar

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebiphar (Nebivolol Hydrochloride)

Nebivolol Hydrochloride, the active ingredient in Nebiphar, is a beta blocker presented as an oral formulation for oral use. It is indicated for the management of hypertension and heart failure in adult patients, where it helps lower blood pressure and improve cardiac function through selective β1‑adrenergic blockade combined with nitric‑oxide‑mediated vasodilation.

GNH India supplies Nebiphar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑controlled manufacturing and reliable distribution across global markets and compliance with regulatory standards.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

  • Nebivolol is used to treat conditions within the cardiovascular disease family by modulating heart rate and vascular tone.
  • Hypertension: lowers systolic and diastolic blood pressure in adult patients.
  • Heart failure: improves left‑ventricular ejection fraction and reduces symptoms of chronic heart failure.
  • Elderly patients with hypertension: provides effective blood‑pressure control with a favorable tolerability profile.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors on cardiac myocytes, reducing heart rate and contractility. In addition, it stimulates endothelial nitric‑oxide synthase, leading to nitric‑oxide‑mediated vasodilation, which together lower systemic vascular resistance and blood pressure while improving myocardial oxygen supply.

Side Effects

Nebivolol may be associated with several adverse reactions, which are categorized by frequency and clinical significance.

Common Side Effects

  • Headache: mild to moderate headache, often transient.
  • Dizziness: especially on standing or rapid position changes.
  • Fatigue: general tiredness or lack of energy.
  • Nausea: occasional upset stomach or feeling of queasiness.

Serious or Rare Side Effects

  • Bradycardia: excessively slow heart rate that may require medical attention.
  • Hypotension: marked drop in blood pressure leading to faintness.
  • Heart block: atrioventricular conduction disturbances that can be life‑threatening.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate care.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.
  • Monitor blood pressure: adjust therapy based on regular readings.
  • Assess heart rate: avoid use in patients with severe bradycardia.
  • Caution in hepatic impairment: dose may need adjustment in moderate to severe liver disease.
  • Avoid abrupt discontinuation: risk of rebound hypertension or tachycardia.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with several drug classes, influencing its safety and efficacy.

Major Interactions (Avoid)

  • Combined with other β‑blockers: risk of excessive bradycardia and hypotension.
  • Concomitant use with calcium‑channel blockers verapamil or diltiazem: may cause severe AV block.
  • Potent CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): increase nebivolol plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance the hypotensive effect, requiring blood‑pressure monitoring.
  • ACE inhibitors or ARBs: additive blood‑pressure lowering effect; monitor for symptomatic hypotension.

Frequently Asked Questions

Nebiphar contains nebivolol hydrochloride and is prescribed to lower high blood pressure and to treat chronic heart failure in adult patients. It works by reducing heart rate and relaxing blood vessels, helping to control hypertension and improve cardiac function.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. It also stimulates nitric‑oxide release from the endothelium, causing vasodilation. The combined effect reduces systemic vascular resistance and lowers blood pressure while improving myocardial oxygen delivery.

The appropriate dose of Nebiphar is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for nebivolol during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their doctor.

To order Nebiphar, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Nebiphar (nebivolol) offers a unique nitric‑oxide‑mediated vasodilatory effect that many traditional β‑blockers, such as metoprolol, lack. This can provide better blood‑pressure control with a lower incidence of metabolic side effects, though individual response varies and choice of therapy should be individualized by the clinician.

Nebiphar should be stored at ambient temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Nebiphar is taken orally, usually once daily, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include marked bradycardia, severe hypotension, atrioventricular heart block, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, very slow heart rate, chest pain, or signs of a severe allergic response.

Nebiphar is contraindicated in patients with severe bradycardia, second‑ or third‑degree AV block, cardiogenic shock, or uncontrolled heart failure. It should also be avoided in individuals with known hypersensitivity to nebivolol or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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