Product image of Nebivolek (Nebivolol Hydrochloride) supplied by GNH India

Nebivolek

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebivolek (Nebivolol Hydrochloride)

Nebivolol, the active ingredient in Nebivolek, is a β1‑selective beta‑blocker presented as an oral tablet for oral use. It is indicated for the management of hypertension and chronic heart failure in adult patients. It offers a favorable hemodynamic profile by promoting vasodilation through nitric oxide release, which can improve tolerability compared with non‑selective beta‑blockers.\n\nGNH India supplies Nebivolek as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU quality standards and is manufactured under strict Good Manufacturing Practices, ensuring consistent potency and safety for patients.

Manufacturer / TM Owner

Sandoz Gmbh

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Indications & Clinical Uses

  • Nebivolol is a β1‑selective beta‑blocker used to treat cardiovascular conditions related to high blood pressure and cardiac dysfunction.\n- Hypertension: reduces systolic and diastolic blood pressure, decreasing cardiovascular risk.\n- Chronic heart failure: improves left ventricular ejection fraction and reduces symptoms of fluid overload.\n- Left ventricular systolic dysfunction: enhances cardiac output and may delay disease progression.

How It Works

  • Nebivolol selectively antagonizes β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and myocardial contractility, which lowers cardiac output and blood pressure. In addition, it stimulates endothelial nitric oxide synthase, increasing nitric oxide production that causes peripheral vasodilation and reduces systemic vascular resistance. The combined β1‑blockade and nitric‑oxide mediated vasodilation result in overall clinically significant effective antihypertensive and heart‑failure therapeutic actions.

Side Effects

  • Nebivolol may be associated with a range of adverse reactions, which are categorized by frequency.\n\nCommon Side Effects:\n- Headache\n- Dizziness or light‑headedness\n- Fatigue or tiredness\n- Nasal congestion\n- Nausea\n\nSerious or Rare Side Effects:\n- Severe bradycardia\n- Marked hypotension\n- Heart block or AV conduction disturbances\n- Bronchospasm in patients with reactive airway disease\n- Allergic reactions such as rash or angioedema\n- Hepatic enzyme elevations

Precautions & Warnings

  • When prescribing Nebivolol, clinicians should consider several precautionary measures to ensure safe use.\n- Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension.\n- Cardiac function assessment: evaluate heart rate and ECG, especially in patients with conduction disorders.\n- Asthma or COPD caution: use with care as β‑blockade may precipitate bronchospasm.\n- Concomitant β‑blocker use: avoid combining with other β‑blockers to prevent additive effects.\n- Renal or hepatic impairment: dose adjustment may be required in moderate to severe dysfunction.\n- Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

  • Nebivolol can interact with other medicines, altering its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Combined use with other β‑blockers: may cause excessive bradycardia and hypotension.\n- Co‑administration with non‑dihydropyridine calcium channel blockers (verapamil, diltiazem): increases risk of cardiac conduction delays.\n- Strong CYP2D6 inhibitors (paroxetine, fluoxetine, quinidine): raise nebivolol plasma concentrations.\n\nModerate Interactions (Monitor Closely):\n- Diuretics (thiazides, loop diuretics): additive blood‑pressure lowering effect, monitor for dehydration.\n- ACE inhibitors or ARBs: may enhance antihypertensive effect, watch for symptomatic hypotension.\n- Antidiabetic agents (insulin, sulfonylureas): nebivolol can mask hypoglycaemia symptoms, require glucose monitoring.

Frequently Asked Questions

Nebivolek contains nebivolol, a β1‑selective beta‑blocker indicated for the treatment of essential hypertension and chronic heart failure in adult patients. It helps lower blood pressure and improves cardiac output, reducing symptoms such as dyspnea and fatigue associated with heart failure. The medication is prescribed by a qualified healthcare professional.

Nebivolol works by selectively blocking β1‑adrenergic receptors in the heart, which decreases heart rate and contractility, leading to reduced cardiac output and blood pressure. In addition, it stimulates endothelial nitric‑oxide synthase, increasing nitric‑oxide release that causes peripheral vasodilation and lowers systemic vascular resistance. This dual action provides antihypertensive and heart‑failure benefits.

The dosage of Nebivolek is individualized by the prescribing clinician based on the patient’s clinical condition, blood‑pressure targets, and tolerance. Typical starting doses for hypertension range from 5 mg once daily, with possible titration to higher doses as needed, while heart‑failure dosing may differ. Exact dosing instructions must be taken from the prescriber’s order.

The safety of nebivolol in pregnancy and lactation has not been fully established, and it is generally classified as contraindicated or to be used only if the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy,

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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