Product image of Nebivolol Accord (Nebivolol) supplied by GNH India

Nebivolol Accord

Active Ingredient:
Nebivolol
Origin:
EU

Nebivolol Accord (Nebivolol)

Nebivolol, the active ingredient in Nebivolol Accord, is a beta blocker presented as an oral tablet for oral use. It is indicated for the management of hypertension and heart failure in adult patients, where reduction of blood pressure and improvement of cardiac function are required. Nebivolol works by selectively blocking β1‑adrenergic receptors and enhancing nitric‑oxide mediated vasodilation, which together lower peripheral resistance.

GNH India supplies Nebivolol Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Nebivolol is used within the cardiovascular therapeutic area to control blood pressure and support heart function.

  • Hypertension: lowers systolic and diastolic blood pressure, reducing the risk of stroke and myocardial infarction.
  • Heart failure: improves left ventricular ejection fraction and decreases symptoms such as dyspnea and fatigue.
  • Post‑myocardial infarction (when indicated): helps prevent adverse cardiac remodeling and recurrent ischemic events.

How It Works

  • Nebivolol selectively antagonizes β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility, which reduces cardiac output. Concurrently, it stimulates endothelial nitric‑oxide synthase, increasing nitric‑oxide release that causes vasodilation and lowers peripheral vascular resistance, together contributing to blood pressure reduction and improved cardiac efficiency.

Side Effects

Nebivolol may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain often occurring early in therapy.
  • Dizziness or light‑headedness: related to blood pressure lowering.
  • Fatigue or tiredness: may be noticeable during dose titration.
  • Bradycardia: slower than normal heart rate.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe bradycardia: heart rate dropping to dangerously low levels.
  • Symptomatic hypotension: marked drop in blood pressure causing fainting.
  • Heart block: impairment of electrical conduction.
  • Bronchospasm: especially in patients with reactive airway disease.
  • Allergic reactions: rash, itching, or anaphylaxis in rare cases.

Precautions & Warnings

Before initiating Nebivolol therapy, clinicians should consider several safety measures.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Cardiac function evaluation: review baseline heart rate and ECG for conduction abnormalities.
  • Concomitant beta‑blocker use: avoid duplicate therapy that may increase bradycardia risk.
  • Hepatic impairment: dose adjustment may be needed in patients with liver dysfunction.
  • Pregnancy and lactation: use only if potential benefits justify potential risks.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with other medicines, affecting its safety and efficacy.

Major Interactions (Avoid)

  • Other beta‑blockers: additive negative chronotropic effects may cause severe bradycardia.
  • Calcium‑channel blockers (verapamil, diltiazem): can enhance bradycardia and AV‑block.
  • Potent CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): increase nebivolol plasma concentrations.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect.
  • Diuretics: risk of orthostatic hypotension when combined.
  • Antidiabetic agents: nebivolol may mask hypoglycemia symptoms; monitor glucose levels.

Frequently Asked Questions

Nebivolol Accord is prescribed for adults with hypertension and for those with chronic heart failure. In hypertension, it helps lower elevated blood pressure, while in heart failure it improves cardiac output and reduces symptoms such as shortness of breath and fatigue.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. It also stimulates nitric‑oxide release from the endothelium, causing vasodilation and reducing peripheral vascular resistance, which together lower systemic blood pressure.

The specific dose of Nebivolol Accord is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concurrent medications. Dosage adjustments may be required for renal or hepatic impairment.

Nebivolol Accord should be used during pregnancy or lactation only if the potential benefits outweigh the possible risks to the fetus or infant. Healthcare providers typically evaluate the individual situation before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nebivolol is a highly selective β1‑blocker that also enhances nitric‑oxide mediated vasodilation, offering a favorable profile for patients who may experience peripheral vasoconstriction with non‑selective agents. This dual action can result in better blood pressure control with fewer metabolic side effects compared with some older beta blockers.

Nebivolol Accord should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain product stability.

Nebivolol Accord is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include severe bradycardia, symptomatic hypotension, heart block, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, rapid heartbeat, difficulty breathing, or signs of an allergic response.

Nebivolol Accord is contraindicated in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and individuals in cardiogenic shock. It should also be used with caution in patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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