Product image of Nebivolol Ciclum (Nebivolol) supplied by GNH India

Nebivolol Ciclum

Active Ingredient:
Nebivolol
Origin:
EU

Nebivolol Ciclum (Nebivolol)

Nebivolol, the active ingredient in Nebivolol Ciclum, is a beta blocker presented as an oral tablet for oral use. It treats hypertension and heart failure in adult patients.

GNH India supplies Nebivolol Ciclum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

  • Nebivolol is used in cardiovascular therapy to control blood pressure and improve cardiac function.
  • Hypertension: reduces systolic and diastolic blood pressure in patients with primary hypertension.
  • Heart failure: improves left‑ventricular ejection fraction and reduces symptoms in chronic heart failure.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors, decreasing heart rate and myocardial contractility. In addition, it stimulates endothelial nitric oxide synthase, causing nitric‑oxide‑mediated vasodilation, which further lowers peripheral vascular resistance and blood pressure.

Side Effects

Nebivolol may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness, especially on standing.
  • Fatigue or tiredness.
  • Nasal congestion.
  • Diarrhea or mild gastrointestinal upset.
  • Bradycardia: heart rate below normal limits.

Serious or Rare Side Effects

  • Severe bradycardia or heart block requiring medical attention.
  • Acute heart failure decompensation.
  • Bronchospasm in patients with reactive airway disease.
  • Significant liver enzyme elevation.
  • Allergic skin reactions such as rash or urticaria.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient history and comorbidities.
  • Cardiovascular monitoring: assess heart rate and blood pressure regularly.
  • Drug interactions: review concomitant medications for potential additive effects.
  • Renal or hepatic impairment: adjust therapy based on organ function.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Elderly patients: start at lower doses and monitor tolerance.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol may interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: risk of excessive β‑blockade.
  • Strong CYP2D6 inhibitors (e.g., paroxetine, quinidine): may increase nebivolol plasma levels.
  • Calcium channel blockers (verapamil, diltiazem): can enhance bradycardia.

Moderate Interactions (Monitor Closely):\n- Diuretics: may potentiate hypotensive effects.

  • Antihypertensive agents (ACE inhibitors, ARBs): additive blood pressure lowering.
  • Antidiabetic drugs: may mask hypoglycemia symptoms.
  • NSAIDs: can reduce antihypertensive efficacy.
  • Antidepressants (SSRIs): monitor for heart rate changes.

Frequently Asked Questions

Nebivolol Ciclum is prescribed to manage primary hypertension and to treat chronic heart failure in adult patients. It helps lower elevated blood pressure and improves cardiac output by reducing heart rate and vascular resistance.

Nebivolol selectively blocks β1‑adrenergic receptors, decreasing heart rate and contractility. It also enhances nitric‑oxide release from the endothelium, causing vasodilation. The combined effect reduces cardiac workload and peripheral resistance, leading to lower blood pressure.

The appropriate dose of Nebivolol Ciclum is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any co‑existing health issues. Dosage adjustments are made according to clinical guidelines.

Nebivolol should only be used during pregnancy or lactation if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers must evaluate each case individually and discuss possible alternatives.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and necessary import documentation.

Nebivolol is a selective β1‑blocker with additional nitric‑oxide‑mediated vasodilation, which may result in fewer metabolic side effects compared with non‑selective beta blockers. Its dual mechanism can provide better blood‑pressure control while preserving endothelial function.

Nebivolol Ciclum should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain stability.

Nebivolol Ciclum is taken orally, usually once daily with or without food, as directed by the prescribing physician. Swallow the tablet whole with a glass of water; do not crush or chew unless instructed otherwise.

Serious risks include severe bradycardia, heart block, acute decompensated heart failure, bronchospasm in patients with asthma or COPD, and significant liver enzyme elevation. Patients should seek immediate medical attention if they experience symptoms such as fainting, chest pain, or severe shortness of breath.

Nebivolol is contraindicated in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and individuals with uncompensated heart failure. Clinicians should also exercise caution in patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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