Product image of Nebivolol Glenmark (Nebivolol Hydrochloride) supplied by GNH India

Nebivolol Glenmark

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebivolol Glenmark (Nebivolol Hydrochloride)

Nebivolol Hydrochloride, the active ingredient in Nebivolol Glenmark, is a beta blocker presented as a tablet for oral use. It treats hypertension in adult patients.

GNH India supplies Nebivolol Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glenmark Arzneimittel Gmbh

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Indications & Clinical Uses

Nebivolol Glenmark is indicated for the management of high‑blood‑pressure disorders.

  • Hypertension: lowers systolic and diastolic blood pressure in adults with essential hypertension.
  • Isolated systolic hypertension: provides effective blood‑pressure control in patients with elevated systolic readings.
  • High‑risk cardiovascular patients: contributes to reduction of cardiovascular risk when used as part of antihypertensive therapy.

How It Works

  • Nebivolol Hydrochloride selectively blocks β1‑adrenergic receptors in cardiac tissue, reducing heart rate and contractility. In addition, it stimulates endothelial nitric oxide synthase, leading to nitric‑oxide‑mediated vasodilation, which together lower systemic vascular resistance and blood pressure.

Side Effects

Nebivolol Glenmark may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness: especially on standing.
  • Fatigue: general tiredness.
  • Nasal congestion: mild blockage of nasal passages.
  • Diarrhea: loose stools.
  • Bradycardia: slower than normal heart rate.

Serious or Rare Side Effects

  • Severe hypotension: markedly low blood pressure.
  • Acute heart failure: worsening of cardiac function.
  • Bronchospasm: narrowing of airways, particularly in asthmatic patients.
  • Allergic reactions: rash, itching, or swelling.
  • Liver enzyme elevation: abnormal liver function tests.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Cardiovascular disease: assess for heart block or severe heart failure.
  • Diabetes: monitor blood glucose as beta‑blockade may mask hypoglycaemia symptoms.
  • Renal impairment: adjust dosing in patients with reduced kidney function.
  • Concomitant medications: review for drugs that also lower heart rate or blood pressure.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Nebivolol Glenmark can interact with several medicines.

Major Interactions (Avoid)

  • Combined β‑blockers: may cause excessive bradycardia or hypotension.
  • Calcium channel blockers (verapamil, diltiazem): increase nebivolol plasma levels.
  • Strong CYP2D6 inhibitors (paroxetine, fluoxetine): raise nebivolol exposure.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotensive effect.
  • Antidiabetic agents: monitor glucose as symptoms of hypoglycaemia may be masked.
  • NSAIDs: can reduce antihypertensive efficacy.
  • Antidepressants (tricyclics): may enhance cardiac conduction effects.

Frequently Asked Questions

Nebivolol Glenmark is prescribed to lower elevated blood pressure in adults with hypertension. By reducing systolic and diastolic pressures, it helps lower the risk of cardiovascular complications associated with uncontrolled hypertension.

Nebivolol selectively blocks β1‑adrenergic receptors, decreasing heart rate and contractility. It also enhances nitric‑oxide release from the endothelium, causing vasodilation and further reducing systemic vascular resistance, which together lower blood pressure.

The exact dose of Nebivolol Glenmark is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any co‑existing health issues. Dosage adjustments are made according to clinical judgment.

Safety of nebivolol in pregnancy and lactation has not been fully established. It should only be used if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nebivolol differs from many beta‑blockers by adding nitric‑oxide‑mediated vasodilation, which can improve endothelial function and cause fewer metabolic side effects. Compared with non‑selective beta‑blockers, it offers greater β1 selectivity, reducing the risk of bronchospasm in susceptible patients.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture, and avoid exposure to direct sunlight to maintain product stability.

Nebivolol Glenmark is taken orally, usually once daily, with or without food, as directed by the prescribing physician. Swallow the tablet whole with a glass of water; do not crush or chew unless instructed otherwise.

Serious risks include severe hypotension, bradycardia, acute heart failure, and bronchospasm in patients with reactive airway disease. Patients should seek immediate medical attention if they experience faintness, rapid weight gain, shortness of breath, or swelling of the extremities.

Nebivolol is contraindicated in patients with known severe bradycardia, second‑ or third‑degree atrioventricular block, cardiogenic shock, or overt heart failure. It should also be avoided in individuals with a documented hypersensitivity to nebivolol or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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