Product image of Nebivolol Glenmark Arzneimittel (Nebivolol Hydrochloride) supplied by GNH India

Nebivolol Glenmark Arzneimittel

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebivolol Glenmark Arzneimittel (Nebivolol Hydrochloride)

Nebivolol, the active ingredient in Nebivolol Glenmark Arzneimittel, is a beta‑adrenergic blocker presented as a tablet for oral use. It is prescribed to lower elevated blood pressure in adult patients with hypertension. The medication works by selectively blocking β1‑adrenergic receptors and enhancing nitric oxide release, which contributes to vasodilation and reduced peripheral resistance.

GNH India supplies Nebivolol Glenmark Arzneimittel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to healthcare providers across multiple regions.

Manufacturer / TM Owner

Glenmark Arzneimittel Gmbh

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Indications & Clinical Uses

Nebivolol is a selective β1‑adrenergic blocker used primarily in the management of high blood pressure.

  • Hypertension: lowers systolic and diastolic blood pressure, reducing cardiovascular risk in adult patients.

How It Works

  • Nebivolol selectively antagonizes β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility. Concurrently, it stimulates endothelial nitric oxide synthase, increasing nitric oxide production which promotes vasodilation and lowers peripheral vascular resistance, thereby contributing to blood pressure reduction.

Side Effects

Nebivolol may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness: often related to blood pressure lowering.
  • Fatigue: general tiredness or lack of energy.
  • Bradycardia: slower than normal heart rate.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Severe bradycardia: markedly low heart rate requiring medical attention.
  • Hypotension: significant drop in blood pressure causing faintness.
  • Bronchospasm: airway constriction, especially in patients with asthma.
  • Allergic reactions: rash, itching, or swelling.
  • Hepatic enzyme elevation: abnormal liver function tests.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient-specific factors and monitor for potential risks.

  • Blood pressure monitoring: ensure adequate control and avoid excessive lowering.
  • Cardiac assessment: evaluate heart rate and rhythm, especially in patients with conduction disorders.
  • Asthma or COPD: use with caution due to possible bronchospasm.
  • Abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Renal impairment: dose adjustment may be required.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with several drug classes, influencing its efficacy and safety.

Major Interactions (Avoid)

  • Other beta‑blockers: additive cardiac depression.
  • Calcium channel blockers (verapamil, diltiazem): increased risk of bradycardia and AV block.
  • Potent CYP2D6 inhibitors (paroxetine, fluoxetine): elevated nebivolol plasma levels.
  • Combined antihypertensives (ACE inhibitors, ARBs): may cause excessive hypotension.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect.
  • Diuretics: risk of electrolyte imbalance and hypotension.
  • Antidiabetic agents: potential alteration of glucose control.
  • Other antiarrhythmics: possible additive effects on cardiac conduction.
  • Alcohol: may enhance dizziness and hypotensive response.

Frequently Asked Questions

Nebivolol Glenmark Arzneimittel is prescribed to treat hypertension, helping to lower elevated systolic and diastolic blood pressure in adult patients. By managing high blood pressure, it reduces the risk of cardiovascular events such as stroke and heart attack.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. It also stimulates nitric oxide release from the endothelium, causing vasodilation and lowering peripheral vascular resistance, which together contribute to reduced blood pressure.

The appropriate dose of nebivolol is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and any comorbidities. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for nebivolol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Nebivolol is a highly selective β1‑blocker with additional nitric‑oxide‑mediated vasodilatory properties, which may offer better tolerability regarding metabolic effects and fewer central nervous system side effects compared with non‑selective beta‑blockers. Clinical choice depends on patient profile, comorbidities and physician judgment.

Nebivolol tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Nebivolol is taken orally, usually once daily, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe bradycardia, marked hypotension, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, rapid heartbeat, difficulty breathing, or swelling of the face or throat.

Nebivolol is contraindicated in patients with known hypersensitivity to the drug, severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and in those with uncompensated heart failure. Caution is also advised for individuals with asthma, severe hepatic impairment, or uncontrolled heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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