Nebivolol/Hydrochlorothiazide Biogaran (Hydrochlorothiazide, Nebivolol)

Nebivolol selectively blocks β1‑adrenergic receptors, which slows the heart rate and reduces myocardial contractility. It also stimulates nitric‑oxide release, leading to vasodilation. Together with hydrochlorothiazide’s diuretic action, this results in a synergistic reduction of arterial pressure.

The appropriate dose is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

Safety data for use during pregnancy or lactation are limited. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details and any necessary import documentation.

Nebivolol/Hydrochlorothiazide combines a β1‑selective blocker with a thiazide diuretic, offering both heart‑rate reduction and volume depletion. Compared with monotherapy agents such as ACE inhibitors or calcium‑channel blockers, this combination can achieve blood‑pressure control with a single pill, potentially improving adherence, but individual tolerability and comorbidities guide the choice of therapy.

Store the tablets at temperatures below 25 °C in their original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date printed on the packaging.

The medication is taken orally, usually once daily, with or without food. Tablets should be swallowed whole with a full glass of water and not chewed, crushed, or split unless specifically instructed by a healthcare professional.

Serious adverse events can include severe hypotension, acute renal impairment, marked electrolyte disturbances (especially low potassium), hyperuricemia leading to gout, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience symptoms like fainting, rapid weight gain, swelling, or difficulty breathing.

The combination is contraindicated in patients with known hypersensitivity to nebivolol, hydrochlorothiazide, or any excipients, as well as those with severe bradycardia, second‑ or third‑degree atrioventricular block, uncompensated heart failure, severe renal impairment, or anuria. Caution is also advised in individuals with asthma, severe hepatic disease, or gout.