Product image of Nebivolol/Hydrochlorothiazide Viatris (Hydrochlorothiazide, Nebivolol) supplied by GNH India

Nebivolol/Hydrochlorothiazide Viatris

Active Ingredient:
Hydrochlorothiazide, Nebivolol
Origin:
EU

Nebivolol/Hydrochlorothiazide Viatris (Hydrochlorothiazide, Nebivolol)

Nebivolol/Hydrochlorothiazide, the active ingredient in Nebivolol/Hydrochlorothiazide Viatris, is a beta‑blocker and thiazide diuretic presented as a tablet for oral use. It is used to lower blood pressure in adults with hypertension.

GNH India supplies Nebivolol/Hydrochlorothiazide Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

Nebivolol/Hydrochlorothiazide is an antihypertensive agent that acts on the cardiovascular system to control elevated blood pressure.

  • Essential hypertension: reduces systolic and diastolic pressure in patients with primary high blood pressure.
  • Isolated systolic hypertension: lowers elevated systolic readings, especially in older adults.
  • Diastolic hypertension: helps bring high diastolic values into the target range.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors, decreasing heart rate and cardiac output, while also stimulating nitric‑oxide release for vasodilation. Hydrochlorothiazide inhibits Na⁺/Cl⁻ reabsorption in the distal convoluted tubule, increasing urinary sodium and water excretion, which reduces plasma volume. The combined actions lower peripheral vascular resistance and overall blood pressure.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness: especially on standing.
  • Fatigue: general tiredness.
  • Cough: dry or productive.
  • Electrolyte disturbances: low potassium or sodium.
  • Increased urination: due to diuretic effect.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Bradycardia: unusually slow heart rate.
  • Acute kidney injury: reduced renal function.
  • Hyperglycaemia: elevated blood sugar levels.
  • Allergic reactions: rash, itching, swelling.
  • Electrolyte imbalance: significant hyponatraemia or hypokalaemia.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Renal impairment: assess kidney function and adjust dosage if needed.
  • Hepatic disease: monitor liver enzymes and use with caution.
  • Electrolyte monitoring: check potassium and sodium levels regularly.
  • Diabetes mellitus: watch for changes in blood glucose control.
  • Gout: be aware of potential uric acid elevation.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Nebivolol/Hydrochlorothiazide may interact with several medicines; review patient medication lists.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase nebivolol levels.
  • Lithium: thiazide component can raise lithium concentrations, risking toxicity.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt diuretic effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives: additive blood‑pressure lowering effect.
  • Antidiabetic agents: possible need for dose adjustment due to altered glucose control.
  • Calcium channel blockers (e.g., verapamil): may increase nebivolol plasma concentration.

Frequently Asked Questions

Nebivolol/Hydrochlorothiazide is prescribed to lower high blood pressure in adults. The combination of a beta‑blocker and a thiazide diuretic provides complementary mechanisms that reduce cardiac output and decrease fluid volume, helping achieve target blood‑pressure goals.

Nebivolol selectively blocks β1‑adrenergic receptors, which slows heart rate and reduces the force of contraction, lowering cardiac output. It also enhances nitric‑oxide release, causing blood‑vessel relaxation and further decreasing peripheral resistance.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for use in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with single‑agent therapies, the nebivolol/hydrochlorothiazide combo offers dual action—beta‑blockade and diuresis—potentially improving blood‑pressure control with a single pill. It may be preferred over monotherapy when both heart‑rate reduction and fluid removal are desired.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include severe hypotension, bradycardia, electrolyte disturbances (especially low potassium), acute kidney injury, and rare allergic reactions. Patients should seek immediate medical attention if they experience fainting, rapid heartbeat, severe dizziness, or swelling.

The combination is contraindicated in patients with known hypersensitivity to either component, severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and those with uncontrolled severe electrolyte imbalances. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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