Product image of Nebivolol Krka (Nebivolol) supplied by GNH India

Nebivolol Krka

Active Ingredient:
Nebivolol
Origin:
EU

Nebivolol Krka (Nebivolol)

Nebivolol, the active ingredient in Nebivolol Krka, is a β1‑selective beta‑blocker presented as an oral tablet for oral administration. It is used to lower blood pressure in essential hypertension and to improve cardiac function in adults with heart failure and reduced ejection fraction.

GNH India supplies Nebivolol Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant documentation for global distribution.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nebivolol is indicated for cardiovascular conditions that involve elevated blood pressure or impaired cardiac output.

  • Essential hypertension: reduces systolic and diastolic blood pressure, helping achieve target levels.
  • Heart failure with reduced ejection fraction: improves ventricular function and decreases hospitalization risk.
  • Left ventricular systolic dysfunction: enhances ejection fraction and overall cardiac performance.

How It Works

  • Nebivolol selectively antagonizes β1‑adrenergic receptors, decreasing heart rate and myocardial contractility, which lowers cardiac output and blood pressure. In addition, it stimulates endothelial nitric oxide synthase, increasing nitric oxide release and causing vasodilation, thereby reducing peripheral vascular resistance and improving arterial compliance.

Side Effects

Nebivolol may cause a range of adverse reactions, some of which are more frequently observed than others.

Common Side Effects

  • Fatigue
  • Headache
  • Dizziness
  • Bradycardia
  • Nausea
  • Peripheral edema

Serious or Rare Side Effects

  • Bronchospasm
  • Severe bradycardia or heart block
  • Marked hypotension
  • Allergic reactions (rash, angioedema)
  • Hepatic dysfunction
  • Exacerbation of heart failure

Precautions & Warnings

Before prescribing Nebivolol, clinicians should consider several safety aspects.

  • Cardiovascular assessment: evaluate heart rate and blood pressure prior to initiation.
  • Respiratory conditions: use cautiously in patients with asthma or COPD.
  • Diabetes management: monitor glucose as beta‑blockade may mask hypoglycaemia symptoms.
  • Concomitant medications: review other antihypertensives to avoid excessive hypotension.
  • Renal impairment: adjust dose in severe renal dysfunction per clinical judgment.
  • Store at ambient temperature: keep below 25°C, retain in original packaging and protect from moisture.

Avoid Interactions

Nebivolol can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Combined use with other β‑blockers may cause profound bradycardia.
  • Calcium‑channel blockers verapamil or diltiazem can precipitate AV‑block.
  • Potent CYP2D6 inhibitors (paroxetine, fluoxetine) increase nebivolol plasma levels.
  • Insulin or sulfonylureas may have hypoglycaemia‑masking effects.
  • Abrupt discontinuation of clonidine while on nebivolol can lead to rebound hypertension.

Moderate Interactions (Monitor Closely)

  • NSAIDs may attenuate antihypertensive efficacy.
  • Diuretics can heighten electrolyte disturbances.
  • ACE inhibitors may enhance hypotensive response.
  • Digoxin may increase risk of bradycardia.
  • Other antidepressants may require dose adjustments or monitoring.

Frequently Asked Questions

Nebivolol Krka is prescribed to lower high blood pressure in essential hypertension and to improve heart function in adults with heart failure that has a reduced ejection fraction. It targets the cardiovascular system to help achieve target blood‑pressure levels and reduce the risk of heart‑related complications.

Nebivolol selectively blocks β1‑adrenergic receptors, which slows heart rate and reduces the force of contraction, lowering cardiac output. At the same time it stimulates nitric‑oxide release from the endothelium, causing blood‑vessel relaxation and decreasing peripheral resistance, which together help control blood pressure.

The appropriate dose of nebivolol is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications. Dosage adjustments may be required for special populations, and the prescriber will provide individualized instructions.

Safety data for nebivolol during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Nebivolol Krka. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nebivolol is a β1‑selective blocker with additional nitric‑oxide‑mediated vasodilatory activity, which may result in fewer metabolic side effects compared with non‑selective beta‑blockers. Its dual mechanism can provide effective blood‑pressure control while preserving endothelial function, distinguishing it from many older agents.

Store Nebivolol Krka at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Nebivolol Krka is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water, and patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as angioedema. Patients should be monitored for these events, especially when initiating therapy or adjusting doses.

Nebivolol is contraindicated in individuals with known hypersensitivity to nebivolol or any component of the formulation, in patients with severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and in those with uncompensated heart failure or cardiogenic shock.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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