Product image of Nebivolol Krka (Nebivolol) supplied by GNH India

Nebivolol Krka

Active Ingredient:
Nebivolol
Origin:
EU

Nebivolol Krka (Nebivolol)

Nebivolol, the active ingredient in Nebivolol Krka, is a beta blocker presented as an oral tablet for oral use. It treats hypertension and heart failure in adult patients.
GNH India supplies Nebivolol Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nebivolol is a selective β1‑adrenergic antagonist used in cardiovascular disease management.

  • Hypertension: lowers systolic and diastolic blood pressure by reducing cardiac output and promoting vasodilation.
  • Heart failure: improves left‑ventricular ejection fraction and reduces symptoms in chronic heart failure.
  • Cardiovascular risk reduction: contributes to lower incidence of cardiovascular events in patients with high blood pressure.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility. In addition, it stimulates endothelial nitric oxide synthase, leading to nitric‑oxide‑mediated vasodilation, which further reduces peripheral vascular resistance and blood pressure.

Side Effects

Nebivolol may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate pain often occurring early in therapy.
  • Dizziness: sensation of light‑headedness, especially when standing quickly.
  • Fatigue: feeling unusually tired or weak.
  • Nausea: mild stomach upset or queasiness.

Serious or Rare Side Effects

  • Severe bradycardia: markedly reduced heart rate requiring medical attention.
  • Hypotension: dangerously low blood pressure with risk of fainting.
  • Heart block: impaired electrical conduction that may necessitate pacemaker placement.

Precautions & Warnings

Use Nebivolol with clinical vigilance in specific situations.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic disease: exercise caution in severe liver dysfunction.
  • Concomitant beta‑blockers: avoid additive cardiac depression.
  • Abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Nebivolol can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective beta blockers: may cause excessive bradycardia.
  • Calcium‑channel blockers (verapamil, diltiazem): increase risk of AV‑block.
  • Clonidine: abrupt withdrawal can precipitate rebound hypertension.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance hypotensive effect.

  • ACE inhibitors/ARBs: additive blood‑pressure lowering.
  • Antidiabetic agents: may mask hypoglycaemia symptoms.

Frequently Asked Questions

Nebivolol Krka is prescribed to manage high blood pressure (hypertension) and to treat chronic heart failure. By lowering blood pressure and improving cardiac output, it helps reduce the risk of cardiovascular complications in adult patients.

Nebivolol works by selectively blocking β1‑adrenergic receptors in the heart, which slows heart rate and reduces contractility. It also stimulates nitric‑oxide production in blood vessels, causing vasodilation and further lowering peripheral resistance and blood pressure.

The appropriate dose of nebivolol is determined by a qualified prescriber based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the dosing instructions provided by their healthcare professional.

Safety data for nebivolol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Nebivolol is a selective β1‑blocker with additional nitric‑oxide‑mediated vasodilatory effects, which may result in fewer metabolic side effects compared with non‑selective beta blockers. Its dual mechanism can offer better blood‑pressure control while preserving endothelial function.

Nebivolol Krka tablets should be stored at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, direct sunlight and excessive heat to maintain product stability.

Nebivolol is taken orally, usually once daily with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water and do not crush or chew it unless instructed otherwise.

Serious risks include severe bradycardia, marked hypotension, and heart block. Patients should be monitored for signs of very slow heart rate, dizziness, fainting, or chest discomfort, and seek immediate medical attention if these occur.

Nebivolol is contraindicated in patients with known hypersensitivity to the drug, severe bradycardia, second‑ or third‑degree atrioventricular block, and those in cardiogenic shock. It should also be used with caution in individuals with severe liver or kidney impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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