Product image of Nebivolol Macleods (Nebivolol) supplied by GNH India

Nebivolol Macleods

Active Ingredient:
Nebivolol
Origin:
EU

Nebivolol Macleods (Nebivolol)

Nebivolol, the active ingredient in Nebivolol Macleods, is a beta blocker presented as a tablet for oral use. It treats hypertension and heart failure in adult patients.

GNH India supplies Nebivolol Macleods as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macleods Pharma España, S.L.U

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Indications & Clinical Uses

  • Nebivolol is a beta‑blocker used in the management of cardiovascular conditions.
  • Hypertension: lowers elevated blood pressure in adult patients.
  • Heart failure: improves symptoms and functional capacity in chronic heart failure.
  • Cardiovascular risk reduction: enhances endothelial function, contributing to overall cardiovascular health.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors, reducing heart rate and myocardial contractility. It also stimulates endothelial nitric oxide synthase, increasing nitric oxide release and causing vasodilation, which together lower systemic blood pressure and improve cardiac output.

Side Effects

Nebivolol may cause a range of adverse reactions.

Common Side Effects

  • Headache
  • Dizziness
  • Fatigue
  • Nausea
  • Bradycardia
  • Peripheral edema

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm in patients with asthma
  • Allergic reactions such as rash or angioedema
  • Hepatic enzyme elevation
  • Acute heart failure decompensation

Precautions & Warnings

  • Nebivolol requires careful clinical monitoring.
  • Monitor blood pressure: ensure adequate control without excessive drop.
  • Assess heart rate: watch for bradycardia, especially in patients with conduction disorders.
  • Use caution in asthma or chronic obstructive pulmonary disease: β‑blockade may precipitate bronchospasm.
  • Adjust dose in renal impairment: reduced clearance may increase exposure.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with several medicines.

Major Interactions (Avoid)

  • Other β‑blockers: additive negative chronotropic effects.
  • Calcium‑channel blockers (verapamil, diltiazem): increased risk of AV block.
  • Strong CYP2D6 inhibitors (paroxetine, fluoxetine): may raise nebivolol plasma levels.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may attenuate antihypertensive efficacy.
  • Diuretics: combined use can enhance hypotensive response.
  • Antidiabetic agents: nebivolol may mask hypoglycemia symptoms.

Frequently Asked Questions

Nebivolol Macleods contains the beta‑blocker nebivolol and is prescribed to lower high blood pressure and to manage chronic heart failure in adult patients.

Nebivolol selectively blocks β1‑adrenergic receptors, reducing heart rate and contractility, while also stimulating nitric oxide release from the endothelium, causing vasodilation and lowering blood pressure.

The appropriate dose of nebivolol is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concomitant medications.

Safety of nebivolol in pregnancy or while breastfeeding has not been definitively established; clinicians should weigh potential benefits against possible risks before prescribing.

Submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Nebivolol is distinguished by its additional nitric‑oxide‑mediated vasodilatory effect, which may result in fewer metabolic side effects compared with non‑vasodilating beta‑blockers, while providing comparable blood‑pressure reduction.

Store the tablets at room temperature, below 25 °C, in the original packaging, protected from moisture and direct sunlight to maintain product stability.

Nebivolol Macleods is taken orally, usually once daily, with or without food, as directed by the prescribing healthcare professional.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and rare cases of allergic reactions such as angioedema.

Nebivolol should be avoided in patients with severe bradycardia, advanced atrioventricular block, uncompensated heart failure, or uncontrolled asthma, unless a clinician determines the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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