Product image of Nebivolol +pharma (Nebivolol Hydrochloride) supplied by GNH India

Nebivolol +pharma

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebivolol +pharma (Nebivolol Hydrochloride)

Nebivolol, the active ingredient in Nebivolol +pharma, is a beta blocker presented as an oral tablet for oral use. It treats hypertension and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Nebivolol +pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

+pharma Arzneimittel Gmbh

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Indications & Clinical Uses

  • Nebivolol is a selective β1‑adrenergic antagonist used in cardiovascular disease management.
  • Hypertension: lowers blood pressure by reducing heart rate and peripheral resistance.
  • Heart failure (reduced ejection fraction): improves cardiac output and symptoms by enhancing ventricular filling and decreasing afterload.
  • Left ventricular dysfunction: supports ventricular performance through vasodilation and heart‑rate control.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors, decreasing sympathetic stimulation of the heart, which reduces heart rate and contractility. In addition, it stimulates endothelial nitric oxide synthase, leading to nitric‑oxide‑mediated vasodilation that further lowers systemic vascular resistance and blood pressure.

Side Effects

Nebivolol may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness, especially on standing.
  • Fatigue or tiredness.
  • Nausea or gastrointestinal discomfort.
  • Bradycardia: slower than normal heart rate.

Serious or Rare Side Effects

  • Severe bradycardia or heart block requiring medical attention.
  • Marked hypotension leading to fainting.
  • Acute heart failure decompensation.
  • Bronchospasm in patients with reactive airway disease.
  • Allergic skin reactions such as rash or urticaria.

Precautions & Warnings

  • Nebivolol requires careful assessment before and during therapy.
  • Monitor blood pressure: ensure target levels are achieved without excessive drop.
  • Assess cardiac function: especially in patients with existing heart failure.
  • Use caution in asthma or chronic obstructive pulmonary disease: β‑blockade may exacerbate bronchospasm.
  • Adjust dose in renal impairment: clearance may be reduced.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with several drug classes, influencing its safety and efficacy.

Major Interactions (Avoid)

  • Other β‑blockers: additive negative chronotropic effects.
  • Non‑dihydropyridine calcium‑channel blockers (verapamil, diltiazem): risk of severe bradycardia.
  • Potent CYP2D6 inhibitors (paroxetine, fluoxetine): increase nebivolol plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotensive effect.
  • ACE inhibitors or ARBs: enhanced blood‑pressure lowering.
  • NSAIDs: may blunt antihypertensive response.
  • Anti‑arrhythmic agents (e.g., amiodarone): possible conduction disturbances.

Frequently Asked Questions

Nebivolol +pharma is prescribed to lower high blood pressure (hypertension) and to treat heart failure with reduced ejection fraction. By reducing heart rate and relaxing blood vessels, it helps control blood pressure and improves cardiac output in patients with these cardiovascular conditions.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. It also stimulates nitric‑oxide release from the endothelium, causing vasodilation. The combined effect reduces cardiac output and systemic vascular resistance, leading to lower blood pressure.

The exact dose of nebivolol is determined by the prescribing clinician based on the patient’s medical condition, age, renal function, and response to therapy. Dosage may be started low and titrated upward, but the specific regimen should always follow the prescriber’s instructions.

Nebivolol’s safety in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nebivolol is a highly selective β1‑blocker with additional nitric‑oxide‑mediated vasodilatory activity, which may result in fewer metabolic side effects compared with non‑selective beta blockers. Its dual mechanism can provide better blood‑pressure control while preserving endothelial function, distinguishing it from older agents such as atenolol or metoprolol.

Nebivolol +pharma tablets should be stored at ambient temperature, below 25 °C. Keep them in the original packaging to protect from moisture and light, and store out of reach of children.

Nebivolol +pharma is taken orally, usually once daily with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include severe bradycardia, marked hypotension, heart block, and bronchospasm in patients with reactive airway disease. Patients should be monitored for signs of these conditions, especially when initiating therapy or adjusting the dose.

Nebivolol is contraindicated in patients with known hypersensitivity to the drug, severe bradycardia, second‑ or third‑degree atrioventricular block, cardiogenic shock, or uncontrolled asthma. It should also be used with caution in individuals with severe liver impairment or decompensated heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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