Product image of Nebivolol Tarbis (Nebivolol) supplied by GNH India

Nebivolol Tarbis

Active Ingredient:
Nebivolol
Origin:
EU

Nebivolol Tarbis (Nebivolol)

Nebivolol, the active ingredient in Nebivolol Tarbis, is a beta blocker presented as an oral formulation for oral use. It is used to lower elevated blood pressure and improve cardiovascular outcomes in adults.

GNH India supplies Nebivolol Tarbis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards, manufactures under EU GMP guidelines, and provides reliable global distribution.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

  • Nebivolol is indicated for conditions involving elevated blood pressure and related cardiovascular disorders.
  • Hypertension: reduces systolic and diastolic blood pressure by decreasing heart rate and promoting vasodilation.
  • Heart failure (reduced ejection fraction): improves cardiac output and lowers hospitalization risk in chronic heart‑failure patients.
  • Ischemic heart disease: enhances endothelial function and may alleviate angina symptoms.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility. Simultaneously, it stimulates endothelial nitric‑oxide synthase, increasing nitric‑oxide release which causes peripheral vasodilation. The combined effect reduces systemic vascular resistance and lowers arterial blood pressure.

Side Effects

Nebivolol may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Headache
  • Fatigue
  • Dizziness
  • Nausea
  • Bradycardia
  • Nasal congestion

Serious or Rare Side Effects

  • Severe bradycardia
  • Symptomatic hypotension
  • Heart block
  • Bronchospasm
  • Allergic reactions (rash, swelling, anaphylaxis)
  • Hepatic injury

Precautions & Warnings

  • When prescribing Nebivolol, clinicians should consider several precautionary measures to ensure patient safety.
  • Blood pressure monitoring: check baseline and periodic readings.
  • Asthma or chronic obstructive pulmonary disease: use with caution due to potential bronchoconstriction.
  • Abrupt discontinuation: avoid sudden stop to prevent rebound hypertension.
  • Diabetes mellitus: monitor blood glucose as beta‑blockade may mask hypoglycemia symptoms.
  • Renal impairment: dose adjustment may be required in severe renal dysfunction.
  • Hepatic impairment: use cautiously in patients with significant liver disease.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Nebivolol can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Other beta‑blockers: additive bradycardia and hypotension.
  • Non‑dihydropyridine calcium channel blockers (e.g., verapamil, diltiazem): increased risk of heart block.
  • Clonidine withdrawal: may cause severe hypertension.
  • MAO inhibitors: potential hypertensive crisis.
  • Antiarrhythmic agents (e.g., amiodarone): heightened bradycardia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may attenuate antihypertensive effect.
  • Diuretics: can enhance hypotensive response.
  • ACE inhibitors or ARBs: may increase risk of excessive blood pressure lowering.
  • Antidiabetic drugs: beta‑blockade may mask hypoglycemia signs.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): raise nebivolol plasma levels.

Frequently Asked Questions

Nebivolol Tarbis contains nebivolol, a selective β1‑adrenergic blocker indicated for the treatment of hypertension and, in some jurisdictions, for chronic heart failure with reduced ejection fraction. It helps lower blood pressure and improve cardiovascular outcomes when prescribed by a qualified healthcare professional.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, reducing heart rate and contractility, while simultaneously stimulating endothelial nitric‑oxide synthase. The increased nitric‑oxide release causes vasodilation of peripheral vessels, which together lower systemic vascular resistance and arterial blood pressure.

The appropriate dose of Nebivolol Tarbis is determined individually by the prescribing clinician based on the patient’s blood pressure, renal function, and overall clinical condition. Dosage adjustments may be required for special populations, and patients should follow the prescriber’s instructions precisely.

Safety data for nebivolol in pregnancy and lactation are limited, and the drug is generally classified as contraindicated or to be used only if the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative therapies with their healthcare provider.

To request Nebivolol Tarbis, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with older non‑selective beta‑blockers, nebivolol offers β1‑selectivity and additional nitric‑oxide‑mediated vasodilation, which may result in fewer metabolic side effects and better tolerability. It is often preferred when clinicians seek a beta‑blocker that also improves endothelial function, though individual response varies.

Nebivolol Tarbis should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Nebivolol Tarbis is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water and avoid crushing or chewing unless specifically instructed.

The most serious adverse events include severe bradycardia, symptomatic hypotension, heart block, bronchospasm in patients with reactive airway disease, and rare cases of hepatic injury or allergic reactions. Patients should seek immediate medical attention if they experience fainting, chest pain, difficulty breathing, or signs of an allergic response.

Nebivolol is contraindicated in patients with known hypersensitivity to the drug, severe bradycardia, second‑ or third‑degree atrioventricular block, cardiogenic shock, or uncontrolled severe asthma. Caution is also advised for individuals with significant hepatic impairment or those taking medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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