Product image of Nebivolol Teva (Nebivolol) supplied by GNH India

Nebivolol Teva

Active Ingredient:
Nebivolol
Origin:
EU

Nebivolol Teva (Nebivolol)

Nebivolol, the active ingredient in Nebivolol Teva, is a selective β1‑adrenergic receptor blocker presented as a tablet for oral administration. It is used to lower elevated blood pressure in adult patients, helping to reduce the risk of cardiovascular complications associated with hypertension. The medication works by slowing heart rate and promoting nitric‑oxide‑mediated vasodilation, contributing to improved blood pressure control.

GNH India supplies Nebivolol Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma Belgium N.V./S.A

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Indications & Clinical Uses

Nebivolol is indicated for the management of hypertension, a condition characterized by elevated arterial pressure.

  • Hypertension (essential): lowers systolic and diastolic blood pressure in adult patients.
  • High blood pressure (stage 1 or 2): provides sustained blood pressure control when lifestyle measures are insufficient.
  • Blood pressure management in cardiovascular risk reduction: contributes to decreased risk of stroke and myocardial infarction in hypertensive individuals.

How It Works

  • Nebivolol selectively antagonizes β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and myocardial contractility. In addition, it stimulates endothelial nitric‑oxide synthase, enhancing nitric‑oxide release which leads to vasodilation of peripheral vessels. The combined effect reduces cardiac output and systemic vascular resistance, resulting in lowered arterial blood pressure. These actions together produce a net antihypertensive effect without significant β2‑receptor blockade.

Side Effects

Nebivolol may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness: especially on standing.
  • Fatigue or tiredness: general lack of energy.
  • Nausea: occasional gastrointestinal upset.
  • Bradycardia: slower than normal heart rate.
  • Peripheral edema: mild swelling of ankles or feet.

Serious or Rare Side Effects

  • Severe bradycardia: markedly low heart rate requiring medical attention.
  • Atrioventricular block: impaired electrical conduction of the heart.
  • Hypotension: significant drop in blood pressure causing faintness.
  • Allergic reactions: rash, itching, or swelling of face and throat.
  • Liver injury: elevated liver enzymes or hepatitis.

Precautions & Warnings

When prescribing Nebivolol, clinicians should consider several precautionary measures to ensure safe use.

  • Blood pressure monitoring: check baseline and regularly assess response.
  • Heart rate assessment: avoid use in patients with resting bradycardia (<50 bpm).
  • Liver function: use caution in moderate to severe hepatic impairment.
  • Drug discontinuation: do not stop abruptly; taper under medical supervision.
  • Contraindications: avoid in patients with second‑ or third‑degree AV block.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Other beta‑blockers: additive bradycardia and hypotension.
  • Potent CYP2D6 inhibitors (e.g., paroxetine, quinidine): increase nebivolol plasma levels.
  • Calcium‑channel blockers that depress conduction (e.g., verapamil, diltiazem): may cause excessive heart rate slowing.
  • Antiarrhythmic agents (e.g., amiodarone): heightened risk of AV block.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance antihypertensive effect, monitor blood pressure.
  • Diuretics: combined effect on blood pressure, watch for orthostatic hypotension.
  • NSAIDs: may reduce antihypertensive efficacy, assess renal function.
  • Antidiabetic drugs: beta‑blockade may mask hypoglycemia symptoms, monitor glucose.

Frequently Asked Questions

Nebivolol Teva is used to treat hypertension, helping to lower elevated systolic and diastolic blood pressure in adult patients. By controlling blood pressure, it reduces the risk of cardiovascular events such as stroke and heart attack.

Nebivolol works by selectively blocking β1‑adrenergic receptors in the heart, which slows heart rate and reduces contractility. It also stimulates nitric‑oxide production in blood vessels, causing vasodilation. The combined effect lowers cardiac output and systemic vascular resistance, resulting in reduced blood pressure.

The appropriate dose of nebivolol is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any concomitant medications. Dosage adjustments may be needed for specific patient populations.

Safety data for nebivolol in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To order Nebivolol Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Nebivolol is a selective β1‑blocker with additional nitric‑oxide‑mediated vasodilation, offering heart‑rate control and vasodilatory benefits. Compared with non‑selective beta‑blockers, it has fewer bronchospastic effects, and unlike pure vasodilators, it also reduces cardiac output, providing a balanced antihypertensive profile.

Nebivolol tablets should be stored at room temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat and direct sunlight to maintain product stability throughout its shelf life.

Nebivolol Teva is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include severe bradycardia, atrioventricular block, marked hypotension, and rare cases of liver injury or severe allergic reactions. Patients should seek immediate medical attention if they experience fainting, very slow heart rate, chest pain, or signs of an allergic response.

Nebivolol should be avoided in patients with second‑ or third‑degree atrioventricular block, severe bradycardia, uncompensated heart failure, or known hypersensitivity to the drug. Caution is also advised for individuals with significant liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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