Product image of Nebivolol Teva (Nebivolol Hydrochloride) supplied by GNH India

Nebivolol Teva

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nebivolol Teva (Nebivolol Hydrochloride)

Nebivolol, the active ingredient in Nebivolol Teva, is a selective β1‑adrenergic receptor antagonist presented as an oral tablet for oral administration. It is used to reduce high blood pressure and to improve cardiac output in adult patients diagnosed with hypertension or chronic heart failure, offering vasodilatory benefits through nitric oxide release.

GNH India supplies Nebivolol Teva as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics across global markets with consistent quality and regulatory adherence. All batches are manufactured under GMP conditions and undergo rigorous quality testing before distribution.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Nebivolol is a beta‑blocker indicated for conditions involving elevated cardiovascular workload.

  • Hypertension: reduces systolic and diastolic blood pressure, helping patients reach guideline‑recommended targets.
  • Chronic heart failure: improves left‑ventricular ejection fraction and lowers the risk of hospitalization.
  • Stable angina: decreases myocardial oxygen demand, relieving chest pain during exertion.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility, which lowers cardiac output and blood pressure. In addition, it stimulates endothelial nitric oxide synthase, leading to nitric‑oxide‑mediated vasodilation that further reduces peripheral vascular resistance. The combined β1‑blockade and vasodilatory actions produce an overall antihypertensive and cardioprotective effect.

Side Effects

Nebivolol may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain often occurring early in therapy.
  • Dizziness or light‑headedness: related to blood‑pressure lowering.
  • Fatigue: a feeling of reduced energy or tiredness.
  • Nausea: occasional gastrointestinal upset.
  • Bradycardia: slower than normal heart rate, usually asymptomatic.
  • Peripheral edema: mild swelling of the lower limbs.

Serious or Rare Side Effects

  • Severe bradycardia or heart block: may require medical intervention.
  • Bronchospasm: especially in patients with underlying asthma or COPD.
  • Allergic reactions: rash, itching, or anaphylaxis in rare cases.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Acute heart failure decompensation: worsening symptoms in susceptible individuals.

Precautions & Warnings

Before initiating Nebivolol, clinicians should consider several safety factors.

  • Blood pressure monitoring: ensure adequate control and avoid excessive hypotension.
  • Cardiac conduction: avoid in patients with severe bradycardia or advanced AV block.
  • Respiratory disease: use caution in asthma or chronic obstructive pulmonary disease.
  • Hepatic impairment: dose adjustment may be needed in severe liver dysfunction.
  • Concomitant beta‑blockers: avoid combining with other β‑blockers to prevent additive effects.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): may increase nebivolol plasma levels.
  • Other beta‑blockers: additive negative chronotropic and inotropic effects.
  • Calcium‑channel blockers that affect AV node (e.g., verapamil, diltiazem): risk of severe bradycardia.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotensive response.
  • ACE inhibitors or ARBs: monitor for excessive blood‑pressure reduction.
  • NSAIDs: can blunt antihypertensive effect.
  • Antidiabetic agents: nebivolol may mask hypoglycaemia symptoms.
  • Antiarrhythmic drugs: watch for conduction abnormalities.

Frequently Asked Questions

Nebivolol Teva is an oral tablet containing the beta‑blocker nebivolol. It is prescribed to lower elevated blood pressure in patients with hypertension and to improve cardiac function in adults with chronic heart failure. The medication may also be used to relieve stable angina by reducing myocardial oxygen demand.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility, which lowers cardiac output and blood pressure. At the same time, it stimulates endothelial nitric‑oxide synthase, causing nitric‑oxide‑mediated vasodilation that reduces peripheral vascular resistance, providing a dual antihypertensive effect.

The exact dose of nebivolol is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concomitant medications. Typical starting doses may be low, with gradual titration as needed, but the prescriber sets the final regimen to ensure safety and efficacy.

Limited clinical data are available on nebivolol use during pregnancy and lactation. Because potential risks cannot be ruled out, the drug is generally avoided unless the therapeutic benefit justifies the potential hazard to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Nebivolol Teva. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. After verification, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Nebivolol is distinguished by its high β1‑selectivity and additional nitric‑oxide‑mediated vasodilation, which can result in fewer metabolic side effects and better tolerability compared with non‑selective beta‑blockers. While all beta‑blockers lower heart rate and blood pressure, nebivolol’s vasodilatory property may offer added benefit in patients who experience peripheral fatigue with traditional agents.

Nebivolol tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Do not store in bathrooms or near heat sources. Keep the container tightly closed and out of reach of children.

Nebivolol Teva is taken orally, usually once daily, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule provided by their healthcare professional and not alter the regimen without medical advice.

Serious adverse events include severe bradycardia, heart block, bronchospasm in patients with asthma or COPD, and rare allergic reactions such as rash or anaphylaxis. Patients should seek immediate medical attention if they experience fainting, marked slowing of the heartbeat, difficulty breathing, or signs of a severe allergic response.

Nebivolol is contraindicated in individuals with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia (heart rate < 45 bpm), advanced atrioventricular block without a pacemaker, and patients in cardiogenic shock. Caution is also advised for patients with uncontrolled asthma, severe hepatic impairment, or those already receiving another beta‑blocker.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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